Overview of results from the WaterTox intercalibration and environmental testing phase II program: Part 1, statistical analysis of blind sample testing

2002 ◽  
Vol 17 (3) ◽  
pp. 232-240 ◽  
Author(s):  
A. Ronco ◽  
P. Gagnon ◽  
M. C. Diaz-Baez ◽  
V. Arkhipchuk ◽  
G. Castillo ◽  
...  
2018 ◽  
Author(s):  
Hector Mendoza ◽  
◽  
Victor G. Figueroa ◽  
Walter Gill ◽  
Douglas J. Ammerman ◽  
...  
Keyword(s):  
Phase Ii ◽  

2004 ◽  
Vol 5 (3) ◽  
pp. 74-81
Author(s):  
Ayşegül Ölmez ◽  
Dilek Tüfekcioğlu ◽  
Elgin Erdemli

Abstract Purpose The purpose of this study was to evaluate three different methods (ST: Standard technique; PS: Pea-size; TT: Transverse technique) for dentifrice use in children between 5-7 years of age, as well as to compare the amount of dentifrice dispensed by using tubes with different orifices (cresent or round shaped). Methods and Materials One hundred children who dispensed the dentifrice themselves were asked to apply the quantity of dentifrice they usually used (ST or TT) (Phase-I). In Phase-II they were instructed to apply a PS amount, and in Phase III the TT was demonstrated. Statistical analysis was obtained by using Anova and t-test. Results Most of the children (82 patients) preferred to use the ST rather than the TT (18 patients). A decrease in the dentifrice amount was obtained with both of the shaped orifices after the instruction of PS or demonstration of the TT (p< 0.05). It was observed the amount of dentifrice dispended decreased when a cresent-shaped orifice was used. Conclusion Children usually preferred to use the ST rather than the TT before the instruction or demonstration by the operator. The amount of dentifrice dispensed generally decreased when a dentifrice tube with a crescentshaped orifice was used. Citation Ölmez A, Tüfekciogğlu D, Erdemli E. The Effects of Different Application Techniques and Orifices on the Amount of Dentifrice Dispensed. J Contemp Dent Pract 2004 August;(5)3:074-081.


Author(s):  
Burkett

During October and November 1988, subsurface testing (Phase II) was conducted at prehistoric site 41 BX 785, found in the West Salado Creek Outfall pipeline easement during a pedestrian survey (Phase I) of the project area. The Phase II limited testing determined that the subsurface portion of the prehistoric site is essentially intact, and at least two stratified occupation levels were identified. Although the tests did not produce diagnostic (datable) cultural materials, there is a notable amount of stone tool debit age in the central area, some unidentified biface fragments and burned rock which probably represents displaced hearth stones. We believe the site to be potentially eligible for consideration as a State Archeological Landmark and for nomination to the National Register of Historic Places. Because the site lies within the pipeline easement and will be impacted by the installation of the pipeline, and since it is a potentially significant cultural resource, we recommend that the site be considered for mitigation.


2004 ◽  
Vol 28 (4) ◽  
pp. 343-346
Author(s):  
Olmez Aysegul ◽  
Tufekcioglu Dilek ◽  
Erdemli Elgin

The purpose of this study was to evaluate three different methods (ST: Standart technique; PS: Pea-size; TT:Transverse technique) for dentifrice use in children between 5 to 7 years of age, as well as to compare the amount of dentifrice dispensed by using tubes with different orifices (moon or round shaped). One hundered children who dispensed the dentifrice themselves were asked to apply the quantity of dentifrice they usually used (ST or TT) (Phase-I). In Phase-II, they were instructed to apply a pea-size amount (PS) and finally they were demonstrated to use the transverse technique (TT) in Phase-III. Statistical analysis was obtained by using Anova and t-test. As a result, most of the children (82 patient) preferred to use ST rather than TT (18 patient). A decrease in the amount was obtained with both of the shaped orifices after the instruction of PS or demonstration of TT (p&lt; 0.05). It was observed that the amount of dentifrice dispensed decreased generally when a moon shaped orifice was used.


2011 ◽  
Author(s):  
Wooyong Um ◽  
Michelle M. Valenta ◽  
Chul-Woo Chung ◽  
Jungseok Yang ◽  
Mark H. Engelhard ◽  
...  

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Anna Heath ◽  
◽  
Juan David Rios ◽  
Eleanor Pullenayegum ◽  
Petros Pechlivanoglou ◽  
...  

Abstract Background Procedural sedation and analgesia (PSA) is frequently required to perform closed reductions for fractures and dislocations in children. Intravenous (IV) ketamine is the most commonly used sedative agent for closed reductions. However, as children find IV insertion a distressing and painful procedure, there is need to identify a feasible alternative route of administration. There is evidence that a combination of dexmedetomidine and ketamine (ketodex), administered intranasally (IN), could provide adequate sedation for closed reductions while avoiding the need for IV insertion. However, there is uncertainty about the optimal combination dose for the two agents and whether it can provide adequate sedation for closed reductions. The Intranasal Dexmedetomidine Plus Ketamine for Procedural Sedation (Ketodex) study is a Bayesian phase II/III, non-inferiority trial in children undergoing PSA for closed reductions that aims to address both these research questions. This article presents in detail the statistical analysis plan for the Ketodex trial and was submitted before the outcomes of the trial were available for analysis. Methods/design The Ketodex trial is a multicenter, four-armed, randomized, double-dummy controlled, Bayesian response adaptive dose finding, non-inferiority, phase II/III trial designed to determine (i) whether IN ketodex is non-inferior to IV ketamine for adequate sedation in children undergoing a closed reduction of a fracture or dislocation in a pediatric emergency department and (ii) the combination dose for IN ketodex that provides optimal sedation. Adequate sedation will be primarily measured using the Pediatric Sedation State Scale. As secondary outcomes, the Ketodex trial will compare the length of stay in the emergency department, time to wakening, and adverse events between study arms. Discussion The Ketodex trial will provide evidence on the optimal dose for, and effectiveness of, IN ketodex as an alternative to IV ketamine providing sedation for patients undergoing a closed reduction. The data from the Ketodex trial will be analyzed from a Bayesian perspective according to this statistical analysis plan. This will reduce the risk of producing data-driven results introducing bias in our reported outcomes. Trial registration ClinicalTrials.gov NCT04195256. Registered on December 11, 2019.


2018 ◽  
Author(s):  
Hector Mendoza ◽  
Victor G. Figueroa ◽  
Walter Gill ◽  
Douglas J. Ammerman ◽  
Scott Edward Sanborn
Keyword(s):  
Phase Ii ◽  

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