scholarly journals Anti‐inflammatory effect of fermented brown rice and rice bran with Aspergillus oryzae on mice

2020 ◽  
Author(s):  
Lin Umeyama ◽  
Shiori Kasahara ◽  
Misa Sugawara ◽  
Satoru Yokoyama ◽  
Ikuo Saiki ◽  
...  
Keyword(s):  
Aspergillus Oryzae ◽  
Rice Bran ◽  
Brown Rice ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Rice Bran Oil Attenuates Chronic Inflammation by Inducing M2 Macrophage Switching in High-Fat Diet-Fed Obese Mice

Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 359
Author(s):  
Hyejeong Park ◽  
Seungmin Yu ◽  
Wooki Kim
Keyword(s):  
Adipose Tissue ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Macrophage Polarization ◽  
M2 Macrophage ◽  
Low Grade ◽  
Obese Mice ◽  
Anti Inflammatory ◽  
Low Grade Inflammation ◽  
Inflammatory Effect

Macrophages are involved in all inflammatory processes from killing pathogens to repairing damaged tissue. In the obese state, macrophages infiltrate into enlarged adipose tissue and polarize into pro-inflammatory M1 macrophages, resulting in chronic low-grade inflammation due to the secretion of inflammatory mediators. Rice bran oil (RBO) is an edible oil containing tocopherols, tocotrienols, and γ-oryzanol. Previous research in normal diet-fed mice suggested that RBO mitigates inflammatory responses by modulating mitochondrial respiration of macrophages. Therefore, we investigated if RBO had an anti-inflammatory effect in diet-induced obese mice by assessing the expression of inflammatory markers in epididymal white adipose tissue (eWAT) and polarization of bone marrow-derived macrophages (BMDMs). Rice bran oil exerted a local anti-inflammatory effect in white adipose tissue by suppressing the production of inflammatory mediators and upregulating transcription of anti-inflammatory genes. Rice bran oil also promoted anti-inflammatory M2 macrophage polarization in BMDMs thereby affecting systemic inflammation. Overall, our in vivo and ex vivo results highlight the potential of RBO as a dietary mediator that can ameliorate obesity-induced chronic low-grade inflammation by mediating the expression of inflammation-related factors and macrophage polarization.

scholarly journals Studies on the Quality Control of Fermented Brown Rice and Rice Bran with Aspergillus oryzae by Metabolome Analysis Using 1H-NMR

2019 ◽  
Vol 66 (4) ◽  
pp. 139-146 ◽  
Author(s):  
Yukiko Horie ◽  
Hideyuki Nemoto ◽  
Jin Fujita ◽  
Shigeo Ikegawa ◽  
Yasuhiro Kumaki ◽  
...  
Keyword(s):  
Quality Control ◽  
Aspergillus Oryzae ◽  
Rice Bran ◽  
Brown Rice ◽  
Metabolome Analysis ◽  
H Nmr

scholarly journals δ-Tocotrienol, Isolated from Rice Bran, Exerts an Anti-Inflammatory Effect via MAPKs and PPARs Signaling Pathways in Lipopolysaccharide-Stimulated Macrophages

2018 ◽  
Vol 19 (10) ◽  
pp. 3022 ◽  
Author(s):  
Junjun Shen ◽  
Tao Yang ◽  
Youzhi Xu ◽  
Yi Luo ◽  
Xinyue Zhong ◽  
...  
Keyword(s):  
Rice Bran ◽  
Molecular Mechanisms ◽  
Mitogen Activated Protein Kinase ◽  
Peroxisome Proliferator ◽  
Activator Protein 1 ◽  
Peroxisome Proliferator Activated Receptor ◽  
Tnf Α ◽  
Mitogen Activated Protein ◽  
Anti Inflammatory ◽  
Inflammatory Effect

δ-Tocotrienol, an important component of vitamin E, has been reported to possess some physiological functions, such as anticancer and anti-inflammation, however their molecular mechanisms are not clear. In this study, δ-tocotrienol was isolated and purified from rice bran. The anti-inflammatory effect and mechanism of δ-tocotrienol against lipopolysaccharides (LPS) activated pro-inflammatory mediator expressions in RAW264.7 cells were investigated. Results showed that δ-tocotrienol significantly inhibited LPS-stimulated nitric oxide (NO) and proinflammatory cytokine (TNF-α, IFN-γ, IL-1β and IL-6) production and blocked the phosphorylation of c-Jun N-terminal kinase (JNK) and extracellular regulated protein kinases 1/2 (ERK1/2). δ-Tocotrienol repressed the transcriptional activations and translocations of nuclear factor-kappa B (NF-κB) and activator protein-1 (AP-1), which were closely related with downregulated cytokine expressions. Meanwhile, δ-tocotrienol also affected the PPAR signal pathway and exerted an anti-inflammatory effect. Taken together, our data showed that δ-tocotrienol inhibited inflammation via mitogen-activated protein kinase (MAPK) and peroxisome proliferator-activated receptor (PPAR) signalings in LPS-stimulated macrophages.

scholarly journals Fermented Brown Rice and Rice Bran with Aspergillus oryzae (FBRA) Prevents Inflammation-Related Carcinogenesis in Mice, through Inhibition of Inflammatory Cell Infiltration

Nutrients ◽  
2015 ◽  
Vol 7 (12) ◽  
pp. 10237-10250 ◽  
Author(s):  
Kunishige Onuma ◽  
Yusuke Kanda ◽  
Saori Suzuki Ikeda ◽  
Ryuta Sakaki ◽  
Takuya Nonomura ◽  
...  
Keyword(s):  
Aspergillus Oryzae ◽  
Rice Bran ◽  
Inflammatory Cell ◽  
Brown Rice ◽  
Inflammatory Cell Infiltration ◽  
Cell Infiltration
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