Bone regeneration induced by adenoviral vectors carryingtil-1/Cbfa1 genes implanted with biodegradable porous materials in animal models of osteonecrosis of the femoral head

2008 ◽  
Vol 2 (2-3) ◽  
pp. 164-167 ◽  
Author(s):  
Shinsuke Sakai ◽  
Miki Tamura ◽  
Hajime Mishima ◽  
Hiroko Kojima ◽  
Toshimasa Uemura
Keyword(s):  
Femoral Head ◽  
Animal Models ◽  
Bone Regeneration ◽  
Porous Materials ◽  
Adenoviral Vectors

Phosphodiesterase‐5 inhibition improves bone regeneration at the early stages of ischemic osteonecrosis of the femoral head in rats

2020 ◽  
Author(s):  
André L. Campos Pessoa ◽  
Victor H. V. Oliveira Araújo ◽  
Ana L. Rosa Nascimento ◽  
Nelson Elias ◽  
Jorge J. Carvalho
Keyword(s):  
Femoral Head ◽  
Bone Regeneration ◽  
Early Stages ◽  
Phosphodiesterase 5 ◽  
Ischemic Osteonecrosis

scholarly journals Clinical application of injectable growth factor for bone regeneration: a systematic review

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Yutaka Kuroda ◽  
Toshiyuki Kawai ◽  
Koji Goto ◽  
Shuichi Matsuda
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Femoral Head ◽  
Bone Regeneration ◽  
Clinical Application ◽  
Present Report ◽  
Basic Research ◽  
Limb Ischemia ◽  
Efficacy And Safety ◽  
Gelatin Hydrogel

Abstract Bone regeneration has been the ultimate goal in the field of bone and joint medicine and has been evaluated through various basic research studies to date. Translational research of regenerative medicine has focused on three primary approaches, which are expected to increase in popularity: cell therapy, proteins, and artificial materials. Among these, the local injection of a gelatin hydrogel impregnated with the protein fibroblast growth factor (FGF)-2 is a biomaterial technique that has been developed in Japan. We have previously reported the efficacy of gelatin hydrogel containing injectable FGF-2 for the regenerative treatment of osteonecrosis of the femoral head. Injectable growth factors will probably be developed in the future and gain popularity as a medical approach in various fields as well as orthopedics. Several clinical trials have already been conducted and have focused on this technique, reporting its efficacy and safety. To date, reports of the clinical application of FGF-2 in revascularization for critical limb ischemia, treatment of periodontal disease, early bone union for lower limb fracture and knee osteotomy, and bone regeneration for osteonecrosis of the femoral head have been based on basic research conducted in Japan. In the present report, we present an extensive review of clinical applications using injectable growth factors and discuss the associated efficacy and safety of their administration.

Critical-Size Defects of Animal Models for Bone Regeneration

2018 ◽  
Vol 8 (6) ◽  
pp. 761-770
Author(s):  
Zhao-Yong Lv ◽  
Xi-Meng Chen ◽  
Yu-Jue Zhang ◽  
June Li ◽  
Zhong-Hui Zhao ◽  
...  
Keyword(s):  
Animal Models ◽  
Bone Regeneration ◽  
Critical Size ◽  
Critical Size Defects

Adipose-Derived Stem Cells Enhance Bone Regeneration in Vascular Necrosis of the Femoral Head in the Rabbit

2011 ◽  
Vol 39 (5) ◽  
pp. 1852-1860 ◽  
Author(s):  
A Abudusaimi ◽  
Y Aihemaitijiang ◽  
Y-H Wang ◽  
L Cui ◽  
S Maimaitiming ◽  
...  
Keyword(s):  
Stem Cells ◽  
Femoral Head ◽  
Bone Regeneration ◽  
Adipose Derived Stem Cells
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