Potential effect of mechano growth factor E-domain peptide on axonal guidance growth in primary cultured cortical neurons of rats

2017 ◽  
Vol 12 (1) ◽  
pp. 70-79 ◽  
Author(s):  
Meili Liu ◽  
Xufeng Niu ◽  
Gang Zhou ◽  
Zhengtai Jia ◽  
Ping Li ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cortical Neurons ◽  
Potential Effect ◽  
Axonal Guidance ◽  
Mechano Growth Factor ◽  
Cultured Cortical Neurons ◽  
Axonal Guidance Growth ◽  
Domain Peptide

scholarly journals Protection by nerve growth factor against glutamate-induced cytoxicity in cultured cortical neurons.

1994 ◽  
Vol 64 ◽  
pp. 235
Author(s):  
Shun Shimohama ◽  
Yutaka Tamura ◽  
Akinori Akaike ◽  
Tetsuys Tsukahara ◽  
Jun Kimura
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cortical Neurons ◽  
Nerve Growth ◽  
Cultured Cortical Neurons

Protective effect of nerve growth factor against glutamate-induced neurotoxicity in cultured cortical neurons

1993 ◽  
Vol 632 (1-2) ◽  
pp. 296-302 ◽  
Author(s):  
Shun Shimohama ◽  
Nobuo Ogawa ◽  
Yutaka Tamura ◽  
Akinori Akaike ◽  
Tetsuya Tsukahara ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Protective Effect ◽  
Cortical Neurons ◽  
Nerve Growth ◽  
Cultured Cortical Neurons

Effect of nano-hydroxyapatite on the axonal guidance growth of rat cortical neurons

Nanoscale ◽  
2012 ◽  
Vol 4 (10) ◽  
pp. 3201 ◽  
Author(s):  
Meili Liu ◽  
Gang Zhou ◽  
Wei Song ◽  
Ping Li ◽  
Haifeng Liu ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Axonal Guidance ◽  
Rat Cortical Neurons ◽  
Axonal Guidance Growth

scholarly journals Transforming Growth Factor-β1—Modulated Cerebral Gene Expression

2002 ◽  
Vol 22 (9) ◽  
pp. 1114-1123 ◽  
Author(s):  
Sylvain Lesné ◽  
Sophie Blanchet ◽  
Fabian Docagne ◽  
Géraldine Liot ◽  
Laurent Plawinski ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cortical Neurons ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Wild Type ◽  
Chain Reactions ◽  
Polymerase Chain Reactions ◽  
Cultured Cortical Neurons ◽  
The Central Nervous System ◽  
Tgf Β1

Transforming growth factor-β1 (TGF-β1) plays a central role in the response of the brain to different types of injury. Increased TGF-β1 has been found in the central nervous system of patients with acute or chronic disorders such as stroke or Alzheimer disease. To further define the molecular targets of TGF-β1 in cerebral tissues, a selection of high-density cDNA arrays was used to characterize the mRNA expression profile of 7,000 genes in transgenic mice overexpressing TGF-β1 from astrocytes as compared with the wild-type line. Selected findings were further evaluated by reverse transcription-polymerase chain reactions from independent transgenic and wild-type mice. Furthermore, the expression pattern of seven selected genes such as Delta-1, CRADD, PRSC-1, PAI-1, Apo-1/Fas, CTS-B, and TβR-II were confirmed in either cultured cortical neurons or astrocytes following TGF-β1 treatment. The authors' observations enlarge the repertoire of known TGF-β1–modulated genes and their possible involvement in neurodegenerative processes.

scholarly journals Glutamate Attenuates the Survival Property of IGFR through NR2B Containing N-Methyl-D-aspartate Receptors in Cortical Neurons

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Xia Zhao ◽  
Chao Han ◽  
Zhiwen Zeng ◽  
Linlin Liu ◽  
Haitao Wang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Survival ◽  
Cortical Neurons ◽  
Inhibitory Effect ◽  
Phosphorylation Sites ◽  
Tyrosine Residues ◽  
Cultured Cortical Neurons ◽  
Survival Signaling ◽  
Neurotrophic Factor Signaling ◽  
Nmdar Subunits

Glutamate-induced neurotoxicity is involved in various neuronal diseases, such as Alzheimer’s disease. We have previously reported that glutamate attenuated the survival signaling of insulin-like growth factor-1 (IGF-1) by N-methyl-D-aspartate receptors (NMDARs) in cultured cortical neurons, which is viewed as a novel mechanism of glutamate-induced neurotoxicity. However, the phosphorylation sites of IGF-1 receptor (IGF-1R) affected by glutamate remain to be elucidated, and importantly, which subtype of NMDARs plays a major role in attenuating the prosurvival effect of IGF-1 is still unknown. In the present study, glutamate was found to attenuate the tyrosine phosphorylation of the IGF-1R and the prosurvival effect of IGF-1 in primary cultured cortical neurons. NMDAR inhibitors, MK801 and AP-5, blocked the inhibitory effect of glutamate on the phosphorylation of IGF-1R and increased cell survival, while DNQX, LY341495, and CPCCOEt had no effect. Interestingly, we found that glutamate decreased the phosphorylation of tyrosine residues 1131, 1135/1136, 1250/1251, and 1316, while it had no effect on tyrosine 950 in cortical neurons. Moreover, using specific antagonists and siRNA to downregulate individual NMDAR subunits, we found that the activation of NR2B-containing NMDARs was essential for glutamate to inhibit IGF-1 signaling. These findings indicate that the glutamate-induced attenuation of IGF-1 signaling is mediated by NR2B-containing NMDARs. Our study also proposes a novel mechanism of altering neurotrophic factor signaling by the activation of NMDARs.

scholarly journals Protective effects of nerve growth factor (NGF) against NOInduced neurotoxicity in cultured cortical neurons.

1996 ◽  
Vol 71 ◽  
pp. 192
Author(s):  
Toshiaki Kume ◽  
Hanae Kouchiyama ◽  
Saioshi Kaneke ◽  
Takehiko Maeda ◽  
Shuji Kaneko ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cortical Neurons ◽  
Protective Effects ◽  
Nerve Growth ◽  
Cultured Cortical Neurons
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