scholarly journals Engineered neural tissue with Schwann cell differentiated human dental pulp stem cells: potential for peripheral nerve repair?

2017 ◽  
Vol 11 (12) ◽  
pp. 3362-3372 ◽  
Author(s):  
Kathleen Sanen ◽  
Wendy Martens ◽  
Melanie Georgiou ◽  
Marcel Ameloot ◽  
Ivo Lambrichts ◽  
...  
Keyword(s):  
Stem Cells ◽  
Schwann Cell ◽  
Peripheral Nerve ◽  
Dental Pulp ◽  
Nerve Repair ◽  
Neural Tissue ◽  
Dental Pulp Stem Cells ◽  
Peripheral Nerve Repair ◽  
Human Dental Pulp

scholarly journals Dental pulp stem cells: Novel cell-based and cell-free therapy for peripheral nerve repair

2019 ◽  
Vol 7 (1) ◽  
pp. 1-19 ◽  
Author(s):  
Nessma Sultan ◽  
Laila E Amin ◽  
Ahmed R Zaher ◽  
Ben A Scheven ◽  
Mohammed E Grawish
Keyword(s):  
Stem Cells ◽  
Peripheral Nerve ◽  
Dental Pulp ◽  
Nerve Repair ◽  
Dental Pulp Stem Cells ◽  
Peripheral Nerve Repair

scholarly journals Are human dental pulp stem cells the future of neurodegenerative diseases and nerve injury therapy?*

2020 ◽  
Vol 74 ◽  
pp. 426-436
Author(s):  
Julia Bar ◽  
Iwona Deszcz ◽  
Anna Lis-Nawara ◽  
Piotr Grelewski
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Peripheral Nerve ◽  
Neurodegenerative Diseases ◽  
Nerve Injury ◽  
Dental Pulp ◽  
Peripheral Nerve Injury ◽  
Dental Pulp Stem Cells ◽  
Trophic Factors ◽  
Human Dental Pulp

This review summarizes results from in vitro and in vivo studies which provide evidence that human dental pulp stem cells (hDPSCs) might be a novel treatment strategy for nervous system injuries and neurodegenerative diseases because of their high potential for neurogenic differentiation and secretion of neuron-related trophic factors. It is also worth underlining that hDPSCs are neural crest-derived cells that possess biological properties of mesenchymal stem cells (MSCs). Induced hDPSCs have a high ability to differentiate into neuron-like cells, which show functional activity. hDPSCs express immunomodulatory factors that enhance regeneration and repair of nerve injury. These specific features of undifferentiated and differentiated hDPSCs make these cells promising for the therapy of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s diseases, stroke, spinal cord injury as well as peripheral nerve injury. Recently, investigators propose that the tissue engineering technology, including scaffold, stem cells and growth factor, should provide a new strategy for spinal cord and peripheral nerve injury treatment. hDPSCs should be considered as a good choice for peripheral nerve injury therapy, because they have better potential to differentiate into neural and glial cells than stem cells coming from other sources through the expression of neuronal makers and wide range of neurotropic factors secretion. Unique properties of hDPSCs, such as high proliferation rate, trophic factors expression and stronger neuroprotective effects, indicate that these stem cells may be beneficial in neural disease therapy.

Chrysin induces osteogenic differentiation of human dental pulp stem cells

2021 ◽  
Vol 400 (2) ◽  
pp. 112466
Author(s):  
J.F. Huo ◽  
M.L. Zhang ◽  
X.X. Wang ◽  
D.H. Zou
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Human Dental Pulp

scholarly journals Methylglyoxal-Dependent Glycative Stress Is Prevented by the Natural Antioxidant Oleuropein in Human Dental Pulp Stem Cells through Nrf2/Glo1 Pathway

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 716
Author(s):  
Simona Delle Delle Monache ◽  
Fanny Pulcini ◽  
Roberta Frosini ◽  
Vincenzo Mattei ◽  
Vincenzo Nicola Talesa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Great Promise ◽  
Oral Diseases ◽  
Bioactive Component ◽  
Glycation End Products ◽  
Abnormal Accumulation ◽  
Synthetic Agents ◽  
Human Dental Pulp

Methylglyoxal (MG) is a potent precursor of glycative stress (abnormal accumulation of advanced glycation end products, AGEs), a relevant condition underpinning the etiology of several diseases, including those of the oral cave. At present, synthetic agents able to trap MG are known; however, they have never been approved for clinical use because of their severe side effects. Hence, the search of bioactive natural scavengers remains a sector of strong research interest. Here, we investigated whether and how oleuropein (OP), the major bioactive component of olive leaf, was able to prevent MG-dependent glycative stress in human dental pulp stem cells (DPSCs). The cells were exposed to OP at 50 µM for 24 h prior to the administration of MG at 300 µM for additional 24 h. We found that OP prevented MG-induced glycative stress and DPSCs impairment by restoring the activity of Glyoxalase 1 (Glo1), the major detoxifying enzyme of MG, in a mechanism involving the redox-sensitive transcription factor Nrf2. Our results suggest that OP holds great promise for the development of preventive strategies for MG-derived AGEs-associated oral diseases and open new paths in research concerning additional studies on the protective potential of this secoiridoid.

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