Schwann-like cells differentiated from human dental pulp stem cells combined with a pulsed electromagnetic field can improve peripheral nerve regeneration

2016 ◽  
Vol 37 (3) ◽  
pp. 163-174 ◽  
Author(s):  
Wei-Hong Hei ◽  
Soochan Kim ◽  
Joo-Cheol Park ◽  
Young-Kwon Seo ◽  
Soung-Min Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Electromagnetic Field ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Dental Pulp ◽  
Peripheral Nerve Regeneration ◽  
Dental Pulp Stem Cells ◽  
Pulsed Electromagnetic Field ◽  
Human Dental Pulp ◽  
Pulsed Electromagnetic

Transplanted neural lineage cells derived from dental pulp stem cells promote peripheral nerve regeneration

Human Cell ◽  
2022 ◽  
Author(s):  
Shohei Takaoka ◽  
Fumihiko Uchida ◽  
Hiroshi Ishikawa ◽  
Junko Toyomura ◽  
Akihiro Ohyama ◽  
...  
Keyword(s):  
Stem Cells ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Dental Pulp ◽  
Peripheral Nerve Regeneration ◽  
Dental Pulp Stem Cells ◽  
Neural Lineage

Trophic Effects of Dental Pulp Stem Cells on Schwann Cells in Peripheral Nerve Regeneration

2016 ◽  
Vol 25 (1) ◽  
pp. 183-193 ◽  
Author(s):  
Tsubasa Yamamoto ◽  
Yohei Osako ◽  
Masataka Ito ◽  
Masashi Murakami ◽  
Yuki Hayashi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Schwann Cells ◽  
Dental Pulp ◽  
Peripheral Nerve Regeneration ◽  
Dental Pulp Stem Cells ◽  
Trophic Effects

scholarly journals Neural crest derived stem cells from dental pulp and tooth-associated stem cells for peripheral nerve regeneration

2020 ◽  
Vol 15 (3) ◽  
pp. 373 ◽  
Author(s):  
Gianluca Carnevale ◽  
Alessandra Pisciotta ◽  
Laura Bertoni ◽  
Antonio Vallarola ◽  
Giulia Bertani ◽  
...  
Keyword(s):  
Stem Cells ◽  
Peripheral Nerve ◽  
Neural Crest ◽  
Nerve Regeneration ◽  
Dental Pulp ◽  
Peripheral Nerve Regeneration

scholarly journals Engineered neural tissue with Schwann cell differentiated human dental pulp stem cells: potential for peripheral nerve repair?

2017 ◽  
Vol 11 (12) ◽  
pp. 3362-3372 ◽  
Author(s):  
Kathleen Sanen ◽  
Wendy Martens ◽  
Melanie Georgiou ◽  
Marcel Ameloot ◽  
Ivo Lambrichts ◽  
...  
Keyword(s):  
Stem Cells ◽  
Schwann Cell ◽  
Peripheral Nerve ◽  
Dental Pulp ◽  
Nerve Repair ◽  
Neural Tissue ◽  
Dental Pulp Stem Cells ◽  
Peripheral Nerve Repair ◽  
Human Dental Pulp

scholarly journals Are human dental pulp stem cells the future of neurodegenerative diseases and nerve injury therapy?*

2020 ◽  
Vol 74 ◽  
pp. 426-436
Author(s):  
Julia Bar ◽  
Iwona Deszcz ◽  
Anna Lis-Nawara ◽  
Piotr Grelewski
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Peripheral Nerve ◽  
Neurodegenerative Diseases ◽  
Nerve Injury ◽  
Dental Pulp ◽  
Peripheral Nerve Injury ◽  
Dental Pulp Stem Cells ◽  
Trophic Factors ◽  
Human Dental Pulp

This review summarizes results from in vitro and in vivo studies which provide evidence that human dental pulp stem cells (hDPSCs) might be a novel treatment strategy for nervous system injuries and neurodegenerative diseases because of their high potential for neurogenic differentiation and secretion of neuron-related trophic factors. It is also worth underlining that hDPSCs are neural crest-derived cells that possess biological properties of mesenchymal stem cells (MSCs). Induced hDPSCs have a high ability to differentiate into neuron-like cells, which show functional activity. hDPSCs express immunomodulatory factors that enhance regeneration and repair of nerve injury. These specific features of undifferentiated and differentiated hDPSCs make these cells promising for the therapy of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s diseases, stroke, spinal cord injury as well as peripheral nerve injury. Recently, investigators propose that the tissue engineering technology, including scaffold, stem cells and growth factor, should provide a new strategy for spinal cord and peripheral nerve injury treatment. hDPSCs should be considered as a good choice for peripheral nerve injury therapy, because they have better potential to differentiate into neural and glial cells than stem cells coming from other sources through the expression of neuronal makers and wide range of neurotropic factors secretion. Unique properties of hDPSCs, such as high proliferation rate, trophic factors expression and stronger neuroprotective effects, indicate that these stem cells may be beneficial in neural disease therapy.

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