Enhanced bone regeneration by gelatin-β-tricalcium phosphate composites enabling controlled release of bFGF

2012 ◽  
Vol 8 (8) ◽  
pp. 604-611 ◽  
Author(s):  
Kazuhiko Omata ◽  
Tomonori Matsuno ◽  
Kazunari Asano ◽  
Yoshiya Hashimoto ◽  
Yasuhiko Tabata ◽  
...  
Keyword(s):  
Controlled Release ◽  
Bone Regeneration ◽  
Tricalcium Phosphate

Melatonin decorated 3D-printed beta-tricalcium phosphate scaffolds promoting bone regeneration in a rat calvarial defect model

2019 ◽  
Vol 7 (20) ◽  
pp. 3250-3259 ◽  
Author(s):  
Yali Miao ◽  
Yunhua Chen ◽  
Xiao Liu ◽  
Jingjing Diao ◽  
Naru Zhao ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Calvarial Defect ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
3D Printed ◽  
Rat Calvarial Defect

3D-printed β-TCP scaffolds decorated with melatonin via dopamine mussel-inspired chemistry enhance the osteogenesis and in vivo bone regeneration.

scholarly journals Novel self-gelling injectable hydrogel/alpha-tricalcium phosphate composites for bone regeneration: Physiochemical and microcomputer tomographical characterization

2017 ◽  
Vol 106 (3) ◽  
pp. 822-828 ◽  
Author(s):  
Timothy E. L. Douglas ◽  
Josefien Schietse ◽  
Aneta Zima ◽  
Svetlana Gorodzha ◽  
Bogdan V. Parakhonskiy ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Injectable Hydrogel

Mechanically enhanced lipo-hydrogel with controlled release of multi-type drugs for bone regeneration

2018 ◽  
Vol 12 ◽  
pp. 294-308 ◽  
Author(s):  
Ruoyu Cheng ◽  
Yufei Yan ◽  
Han Liu ◽  
Hao Chen ◽  
Guoqing Pan ◽  
...  
Keyword(s):  
Controlled Release ◽  
Bone Regeneration

scholarly journals Treatment of osteomyelitis defects by a vancomycin-loaded gelatin/β-tricalcium phosphate composite scaffold

2018 ◽  
Vol 7 (1) ◽  
pp. 46-57 ◽  
Author(s):  
J. Zhou ◽  
X. G. Zhou ◽  
J. W. Wang ◽  
H. Zhou ◽  
J. Dong
Keyword(s):  
Controlled Release ◽  
Tricalcium Phosphate ◽  
Chronic Osteomyelitis ◽  
Composite Scaffold ◽  
Bone Defects ◽  
Therapeutic Drug ◽  
Porous Scaffolds ◽  
Composite Scaffolds ◽  
Extended Duration ◽  
Thorough Debridement

Objective In the present study, we aimed to assess whether gelatin/β-tricalcium phosphate (β-TCP) composite porous scaffolds could be used as a local controlled release system for vancomycin. We also investigated the efficiency of the scaffolds in eliminating infections and repairing osteomyelitis defects in rabbits. Methods The gelatin scaffolds containing differing amounts of of β-TCP (0%, 10%, 30% and 50%) were prepared for controlled release of vancomycin and were labelled G-TCP0, G-TCP1, G-TCP3 and G-TCP5, respectively. The Kirby-Bauer method was used to examine the release profile. Chronic osteomyelitis models of rabbits were established. After thorough debridement, the osteomyelitis defects were implanted with the scaffolds. Radiographs and histological examinations were carried out to investigate the efficiency of eliminating infections and repairing bone defects. Results The prepared gelatin/β-TCP scaffolds exhibited a homogeneously interconnected 3D porous structure. The G-TCP0 scaffold exhibited the longest duration of vancomycin release with a release duration of eight weeks. With the increase of β-TCP contents, the release duration of the β-TCP-containing composite scaffolds was decreased. The complete release of vancomycin from the G-TCP5 scaffold was achieved within three weeks. In the treatment of osteomyelitis defects in rabbits, the G-TCP3 scaffold showed the most efficacious performance in eliminating infections and repairing bone defects. Conclusions The composite scaffolds could achieve local therapeutic drug levels over an extended duration. The G-TCP3 scaffold possessed the optimal porosity, interconnection and controlled release performance. Therefore, this scaffold could potentially be used in the treatment of chronic osteomyelitis defects. Cite this article: J. Zhou, X. G. Zhou, J. W. Wang, H. Zhou, J. Dong. Treatment of osteomyelitis defects by a vancomycin-loaded gelatin/β-tricalcium phosphate composite scaffold. Bone Joint Res 2018;7:46–57. DOI: 10.1302/2046-3758.71.BJR-2017-0129.R2.

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