4. Evaluation of the birth defects monitoring program, 1982-1985

Teratology ◽  
1993 ◽  
Vol 48 (6) ◽  
pp. 650-657 ◽  
Author(s):  
Michele C. Lynberg ◽  
Gilberto F. Chavez ◽  
Larry D. Edmonds ◽  
Joseph Mulinare
Keyword(s):  
Birth Defects ◽  
Monitoring Program

Association of the Common Cold in the First Trimester of Pregnancy With Birth Defects

PEDIATRICS ◽  
1993 ◽  
Vol 92 (4) ◽  
pp. 559-563
Author(s):  
Jun Zhang ◽  
Wen-wei Cai
Keyword(s):  
Birth Defects ◽  
Common Cold ◽  
Cleft Lip ◽  
Monitoring Program ◽  
First Trimester ◽  
Relative Risks ◽  
Increased Risk ◽  
First Trimester Of Pregnancy ◽  
The Common ◽  
Pregnancy And Birth

Objective. To examine the association between the common cold with or without fever in the first 3 months of pregnancy and birth defects in offspring. Design. A case-control study. Setting. Data are from the Shanghai Birth Defects Monitoring Program, conducted in 29 hospitals in Shanghai, China from October 1, 1986 to September 30, 1987. Subjects. A total of 986 birth defects cases, 990 frequency-matched live birth controls, and 159 stillbirth controls. Results. Modestly elevated risk of birth defects was identified among women who reported having a cold with or without fever in the first trimester of pregnancy. Notably increased relative risks were observed for anencephalus (odds ratio [OR] = 3.9, 95% confidence interval [CI] = 2.0 to 7.7), spina bifida (OR = 4.1, 95% CI = 1.7 to 9.7), hydrocephalus (OR = 2.3, 95 % CI = 1.1 to 5.1), cleft lip (OR = 2.2, 95 % CI = 1.4 to 3.4), and undescended testicle (OR = 1.8, 95 % CI = 1.0 to 3.0). Our study further found that the overall relative risks were consistent by using two different control groups, suggesting that this association was unlikely to be due to recall or report bias. Conclusion. Common cold in the first trimester of pregnancy may be associated with an increased risk of birth defects in offspring. However, these findings should be interpreted cautiously.

Birth Defects and Visual Impairment

1977 ◽  
Vol 71 (1) ◽  
pp. 2-12
Author(s):  
David R. Zimmerman
Keyword(s):  
Genetic Counseling ◽  
Birth Defects ◽  
Genetic Diagnosis ◽  
Monitoring Program ◽  
Epidemiological Studies ◽  
Vision Impairment ◽  
Fetal Cell ◽  
Therapeutic Abortion ◽  
Fetal Diagnosis ◽  
American Foundation

Epidemiological studies on birth defects and blindness that may be of research or practical value to blindness workers are surveyed. Two of those studies, the Collaborative Perinatal Project and the Birth Defects Monitoring Program, both federally operated, were described to a recent American Foundation for the Blind “Research Seminar on Birth Defects/Blindness and Severe Vision Impairment.” * Recent advances in genetic counseling and genetic diagnosis–particularly fetal diagnosis through the study of fetal cell samples obtained by amniocentesis–are explored as new tools through which blindness workers can assist clients who may wish to minimize their risk of bearing a blind or otherwise defective baby, through therapeutic abortion of afflicted fetuses.

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