Reduction in the frequency of neural tube defects in splotch mice by retinoic acid

Teratology ◽  
1985 ◽  
Vol 32 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Carolyn M. Kapron-Brás ◽  
Daphne G. Trasler
Keyword(s):  
Retinoic Acid ◽  
Neural Tube ◽  
Neural Tube Defects

Genesis and prevention of spinal neural tube defects in the curly tail mutant mouse: involvement of retinoic acid and its nuclear receptors RAR-beta and RAR-gamma

Development ◽  
1995 ◽  
Vol 121 (3) ◽  
pp. 681-691
Author(s):  
W.H. Chen ◽  
G.M. Morriss-Kay ◽  
A.J. Copp
Keyword(s):  
Retinoic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
In Situ Hybridisation ◽  
Tail Bud ◽  
Retinoic Acid Signalling ◽  
All Trans Retinoic Acid ◽  
Posterior Neuropore ◽  
Computerised Image Analysis ◽  
Curly Tail

A role for all-trans-retinoic acid in spinal neurulation is suggested by: (1) the reciprocal domains of expression of the retinoic acid receptors RAR-beta and RAR-gamma in the region of the closed neural tube and open posterior neuropore, respectively, and (2) the preventive effect of maternally administered retinoic acid (5 mg/kg) on spinal neural tube defects in curly tail (ct/ct) mice. Using in situ hybridisation and computerised image analysis we show here that in ct/ct embryos, RAR-beta transcripts are deficient in the hindgut endoderm, a tissue whose proliferation rate is abnormal in the ct mutant, and RAR-gamma transcripts are deficient in the tail bud and posterior neuropore region. The degree of deficiency of RAR-gamma transcripts is correlated with the severity of delay of posterior neuropore closure. As early as 2 hours following RA treatment at 10 days 8 hours post coitum, i.e. well before any morphogenetic effects are detectable, RAR-beta expression is specifically upregulated in the hindgut endoderm, and the abnormal expression pattern of RAR-gamma is also altered. These results suggest that the spinal neural tube defects which characterise the curly tail phenotype may be due to interaction between the ct gene product and one or more aspects of the retinoic acid signalling pathway.

Ectopic cross-talk between thyroid and retinoic acid signaling: A possible etiology for spinal neural tube defects

Gene ◽  
2015 ◽  
Vol 573 (2) ◽  
pp. 254-260 ◽  
Author(s):  
Huili Li ◽  
Baoling Bai ◽  
Qin Zhang ◽  
Yihua Bao ◽  
Jin Guo ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Cross Talk ◽  
Retinoic Acid Signaling

Retinoic acid-induced lumbosacral neural tube defects: myeloschisis and hamartoma

2007 ◽  
Vol 23 (5) ◽  
pp. 549-554 ◽  
Author(s):  
WeiSong Cai ◽  
HongYu Zhao ◽  
JunBin Guo ◽  
Yong Li ◽  
ZhengWei Yuan ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Neural Tube ◽  
Neural Tube Defects

Interaction between the splotch mutation and retinoic acid in mouse neural tube defects in vitro

Teratology ◽  
1988 ◽  
Vol 38 (2) ◽  
pp. 165-173 ◽  
Author(s):  
Carolyn M. Kapron-Brás ◽  
Daphne G. Trasler
Keyword(s):  
Retinoic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Splotch Mutation
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