Prevention of spinal neural tube defects in the curly tail mouse mutant by a specific effect of retinoic acid

1994 ◽  
Vol 199 (2) ◽  
pp. 93-102 ◽  
Author(s):  
Wei-Hwa Chen ◽  
Gillian M. Morriss-Kay ◽  
Andrew J. Copp
Keyword(s):  
Retinoic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Specific Effect ◽  
Mouse Mutant ◽  
Curly Tail

Genesis and prevention of spinal neural tube defects in the curly tail mutant mouse: involvement of retinoic acid and its nuclear receptors RAR-beta and RAR-gamma

Development ◽  
1995 ◽  
Vol 121 (3) ◽  
pp. 681-691
Author(s):  
W.H. Chen ◽  
G.M. Morriss-Kay ◽  
A.J. Copp
Keyword(s):  
Retinoic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
In Situ Hybridisation ◽  
Tail Bud ◽  
Retinoic Acid Signalling ◽  
All Trans Retinoic Acid ◽  
Posterior Neuropore ◽  
Computerised Image Analysis ◽  
Curly Tail

A role for all-trans-retinoic acid in spinal neurulation is suggested by: (1) the reciprocal domains of expression of the retinoic acid receptors RAR-beta and RAR-gamma in the region of the closed neural tube and open posterior neuropore, respectively, and (2) the preventive effect of maternally administered retinoic acid (5 mg/kg) on spinal neural tube defects in curly tail (ct/ct) mice. Using in situ hybridisation and computerised image analysis we show here that in ct/ct embryos, RAR-beta transcripts are deficient in the hindgut endoderm, a tissue whose proliferation rate is abnormal in the ct mutant, and RAR-gamma transcripts are deficient in the tail bud and posterior neuropore region. The degree of deficiency of RAR-gamma transcripts is correlated with the severity of delay of posterior neuropore closure. As early as 2 hours following RA treatment at 10 days 8 hours post coitum, i.e. well before any morphogenetic effects are detectable, RAR-beta expression is specifically upregulated in the hindgut endoderm, and the abnormal expression pattern of RAR-gamma is also altered. These results suggest that the spinal neural tube defects which characterise the curly tail phenotype may be due to interaction between the ct gene product and one or more aspects of the retinoic acid signalling pathway.

Neural tube development in mutant (curly tail) and normal mouse embryos: the timing of posterior neuropore closure in vivo and in vitro

Development ◽  
1982 ◽  
Vol 69 (1) ◽  
pp. 151-167
Author(s):  
A. J. Copp ◽  
M. J. Seller ◽  
P. E. Polani
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Mouse Embryos ◽  
Injection Technique ◽  
Posterior Neuropore ◽  
Curly Tail ◽  
Mechanisms Of Development ◽  
Delayed Closure

A dye-injection technique has been used to determine the developmental stage at which posterior neuropore (PNP) closure occurs in normal and mutant curly tail mouse embryos. In vivo, the majority of non-mutant embryos undergo PNP closure between 30 and 34 somites whereas approximately 50% of all mutant embryos show delayed closure, and around 20% maintain an open PNP even at advanced stages of development. A similar result has been found for embryos developing in vitro from the headfold stage. Later in development, 50–60% of mutant embryos in vivo develop tail flexion defects, and 15–20% lumbosacral myeloschisis. This supports the view that delayed PNP closure is the main developmental lesion leading to the appearance of caudal neural tube defects in curly tail mice. The neural tube is closed in the region of tail flexion defects, but it is locally overexpanded and abnormal in position. The significance of these observations is discussed in relation to possible mechanisms of development of lumbosacral and caudal neural tube defects. This paper constitutes the first demonstration of the development of a genetically induced malformation in vitro.

scholarly journals Reduced Glucose Consumption in the Curly Tail Mouse Does Not Initiate the Pathogenesis Leading to Spinal Neural Tube Defects

1998 ◽  
Vol 128 (10) ◽  
pp. 1819-1828 ◽  
Author(s):  
Marian C. E. Peeters ◽  
Jan L.M.C. Geelen ◽  
Johan W. M. Hekking ◽  
Niels Chavannes ◽  
Joep P. M. Geraedts ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Glucose Consumption ◽  
Curly Tail

Ectopic cross-talk between thyroid and retinoic acid signaling: A possible etiology for spinal neural tube defects

Gene ◽  
2015 ◽  
Vol 573 (2) ◽  
pp. 254-260 ◽  
Author(s):  
Huili Li ◽  
Baoling Bai ◽  
Qin Zhang ◽  
Yihua Bao ◽  
Jin Guo ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Cross Talk ◽  
Retinoic Acid Signaling

Circletail, a New Mouse Mutant with Severe Neural Tube Defects: Chromosomal Localization and Interaction with the Loop-Tail Mutation

Genomics ◽  
2001 ◽  
Vol 78 (1-2) ◽  
pp. 55-63 ◽  
Author(s):  
Jennifer N Murdoch ◽  
Rivka A Rachel ◽  
Saima Shah ◽  
Friedrich Beermann ◽  
Philip Stanier ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Chromosomal Localization ◽  
Mouse Mutant

Reduction in the frequency of neural tube defects in splotch mice by retinoic acid

Teratology ◽  
1985 ◽  
Vol 32 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Carolyn M. Kapron-Brás ◽  
Daphne G. Trasler
Keyword(s):  
Retinoic Acid ◽  
Neural Tube ◽  
Neural Tube Defects
Sign in / Sign up

Export Citation Format

Share Document