Differential effects of amfonelic acid on the haloperidol- and clozapine-induced increase in extracellular dopac in the nucleus accumbens and the striatum

Synapse ◽  
1992 ◽  
Vol 10 (1) ◽  
pp. 71-78 ◽  
Author(s):  
Robert Rivest ◽  
Charles A. Marsden
Keyword(s):  
Nucleus Accumbens ◽  
Differential Effects ◽  
Amfonelic Acid

scholarly journals Differential effects of ethanol in the nucleus accumbens shell of alcohol-preferring (P), alcohol-non-preferring (NP) and Wistar rats: A proteomics study

2009 ◽  
Vol 92 (2) ◽  
pp. 304-313 ◽  
Author(s):  
William J. McBride ◽  
Jonathan A. Schultz ◽  
Mark W. Kimpel ◽  
Jeanette N. McClintick ◽  
Mu Wang ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Wistar Rats ◽  
Nucleus Accumbens Shell ◽  
Differential Effects ◽  
Proteomics Study

Differential effects of dopamine depletion on the binding and mRNA levels of dopamine receptors in the shell and core of the rat nucleus accumbens

1994 ◽  
Vol 25 (3-4) ◽  
pp. 333-343 ◽  
Author(s):  
Ana L. Jongen-Rêlo ◽  
Gerrit J. Docter ◽  
Allert J. Jonker ◽  
Erno Vreugdenhil ◽  
Henk J. Groenewegen ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Receptors ◽  
Mrna Levels ◽  
Dopamine Depletion ◽  
Differential Effects ◽  
Rat Nucleus Accumbens

scholarly journals Differential dopamine release by psychosis-generating and non-psychosis-generating addictive substances in the nucleus accumbens and dorsomedial striatum

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Klara Danielsson ◽  
Rosita Stomberg ◽  
Louise Adermark ◽  
Mia Ericson ◽  
Bo Söderpalm
Keyword(s):  
Drug Abuse ◽  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Negative Symptoms ◽  
Positive Symptoms ◽  
Differential Effects ◽  
Double Probe ◽  
Dorsomedial Striatum ◽  
Da Release

AbstractSchizophrenia is associated with three main categories of symptoms; positive, negative and cognitive. Of these, only the positive symptoms respond well to treatment with antipsychotics. Due to the lack of effect of antipsychotics on negative symptoms, it has been suggested that while the positive symptoms are related to a hyperdopaminergic state in associative striatum, the negative symptoms may be a result of a reduced dopamine (DA) activity in the nucleus accumbens (nAc). Drug abuse is common in schizophrenia, supposedly alleviating negative symptomatology. Some, but not all, drugs aggravate psychosis, tentatively due to differential effects on DA activity in striatal regions. Here this hypothesis was tested in rats by using a double-probe microdialysis technique to simultaneously assess DA release in the nAc and associative striatum (dorsomedial striatum; DMS) following administration of the psychosis-generating substances amphetamine (0.5 mg/kg), cocaine (15 mg/kg) and Δ9-tetrahydrocannabinol (THC, 3 mg/kg), and the generally non-psychosis-generating substances ethanol (2.5 g/kg), nicotine (0.36 mg/kg) and morphine (5 mg/kg). The data show that amphetamine and cocaine produce identical DA elevations both in the nAc and DMS, whereas nicotine increases DA in nAc only. Ethanol and morphine both increased DMS DA, but weaker and in a qualitatively different way than in nAc, suggesting that the manner in which DA is increased might be important to the triggering of psychosis. THC elevated DA in neither region, indicating that the pro-psychotic effects of THC are not related to DA release. We conclude that psychosis-generating substances affect striatal DA release differently than non-psychosis-generating substances.

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