scholarly journals Ethanol and phencyclidine interact with respect to nucleus accumbens dopamine release: differential effects of administration order and pretreatment protocol

2010 ◽  
Author(s):  
Pickering
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Differential Effects

scholarly journals Differential dopamine release by psychosis-generating and non-psychosis-generating addictive substances in the nucleus accumbens and dorsomedial striatum

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Klara Danielsson ◽  
Rosita Stomberg ◽  
Louise Adermark ◽  
Mia Ericson ◽  
Bo Söderpalm
Keyword(s):  
Drug Abuse ◽  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Negative Symptoms ◽  
Positive Symptoms ◽  
Differential Effects ◽  
Double Probe ◽  
Dorsomedial Striatum ◽  
Da Release

AbstractSchizophrenia is associated with three main categories of symptoms; positive, negative and cognitive. Of these, only the positive symptoms respond well to treatment with antipsychotics. Due to the lack of effect of antipsychotics on negative symptoms, it has been suggested that while the positive symptoms are related to a hyperdopaminergic state in associative striatum, the negative symptoms may be a result of a reduced dopamine (DA) activity in the nucleus accumbens (nAc). Drug abuse is common in schizophrenia, supposedly alleviating negative symptomatology. Some, but not all, drugs aggravate psychosis, tentatively due to differential effects on DA activity in striatal regions. Here this hypothesis was tested in rats by using a double-probe microdialysis technique to simultaneously assess DA release in the nAc and associative striatum (dorsomedial striatum; DMS) following administration of the psychosis-generating substances amphetamine (0.5 mg/kg), cocaine (15 mg/kg) and Δ9-tetrahydrocannabinol (THC, 3 mg/kg), and the generally non-psychosis-generating substances ethanol (2.5 g/kg), nicotine (0.36 mg/kg) and morphine (5 mg/kg). The data show that amphetamine and cocaine produce identical DA elevations both in the nAc and DMS, whereas nicotine increases DA in nAc only. Ethanol and morphine both increased DMS DA, but weaker and in a qualitatively different way than in nAc, suggesting that the manner in which DA is increased might be important to the triggering of psychosis. THC elevated DA in neither region, indicating that the pro-psychotic effects of THC are not related to DA release. We conclude that psychosis-generating substances affect striatal DA release differently than non-psychosis-generating substances.

scholarly journals Elevation of Ambient Room Temperature has Differential Effects on MDMA-Induced 5-HT and Dopamine Release in Striatum and Nucleus Accumbens of Rats

2005 ◽  
Vol 30 (7) ◽  
pp. 1312-1323 ◽  
Author(s):  
Esther O'Shea ◽  
Isabel Escobedo ◽  
Laura Orio ◽  
Veronica Sanchez ◽  
Miguel Navarro ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Room Temperature ◽  
Differential Effects ◽  
Ambient Room Temperature

Differential effects of amphetamine isomers on dopamine release in the rat striatum and nucleus accumbens core

2004 ◽  
Vol 178 (2-3) ◽  
pp. 250-258 ◽  
Author(s):  
Paul E. A. Glaser ◽  
Theresa C. Thomas ◽  
B. Matthew Joyce ◽  
F. Xavier Castellanos ◽  
Greg A. Gerhardt
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Rat Striatum ◽  
Nucleus Accumbens Core ◽  
Differential Effects ◽  
Accumbens Core
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