Neuroprotective role of Nrf2 on hypoxic‐ischemic brain injury in neonatal mice

Synapse ◽  
2020 ◽  
Author(s):  
Wei Zhang ◽  
Xiujuan Dong ◽  
Sumian Dou ◽  
Long Yang
Keyword(s):  
Brain Injury ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Neonatal Mice ◽  
Hypoxic Ischemic Brain Injury

Trace Fear Conditioning Detects Hypoxic-Ischemic Brain Injury in Neonatal Mice

2011 ◽  
Vol 33 (3-4) ◽  
pp. 222-230 ◽  
Author(s):  
Katarina Järlestedt ◽  
Alison L. Atkins ◽  
Henrik Hagberg ◽  
Marcela Pekna ◽  
Carina Mallard
Keyword(s):  
Brain Injury ◽  
Fear Conditioning ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Neonatal Mice ◽  
Trace Fear Conditioning ◽  
Hypoxic Ischemic Brain Injury ◽  
Trace Fear

scholarly journals An Isolation Method for Assessment of Brain Mitochondria Function in Neonatal Mice with Hypoxic-Ischemic Brain Injury

2008 ◽  
Vol 30 (5) ◽  
pp. 319-324 ◽  
Author(s):  
Casper S. Caspersen ◽  
Alexander Sosunov ◽  
Irina Utkina-Sosunova ◽  
Veniamin I. Ratner ◽  
Anatoly A. Starkov ◽  
...  
Keyword(s):  
Brain Injury ◽  
Brain Mitochondria ◽  
Ischemic Brain Injury ◽  
Isolation Method ◽  
Ischemic Brain ◽  
Neonatal Mice ◽  
Hypoxic Ischemic Brain Injury

Temporal profiles of cerebral blood flow in neonatal mice with hypoxic–ischemic brain injury

2011 ◽  
Vol 71 ◽  
pp. e403
Author(s):  
Makiko Ohshima ◽  
Masahiro Tsuji ◽  
Yukiko Kasahara ◽  
Akihiko Taguchi ◽  
Tomoaki Ikeda
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Injury ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Neonatal Mice ◽  
Hypoxic Ischemic Brain Injury ◽  
Temporal Profiles

Neonatal mice lacking functional Fas death receptors are resistant to hypoxic–ischemic brain injury

2004 ◽  
Vol 17 (1) ◽  
pp. 89-98 ◽  
Author(s):  
Ernest M. Graham ◽  
R.Ann Sheldon ◽  
Debra L. Flock ◽  
Donna M. Ferriero ◽  
Lee J. Martin ◽  
...  
Keyword(s):  
Brain Injury ◽  
Death Receptors ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Neonatal Mice ◽  
Hypoxic Ischemic Brain Injury

scholarly journals Insights into the role of iron in immature rat model of hypoxic-ischemic brain injury

2016 ◽  
Vol 12 (3) ◽  
pp. 1723-1731
Author(s):  
Zi-Wei Wang ◽  
Li-Jun Yang ◽  
Ying-Xue Ding ◽  
Yan-Zhong Chang ◽  
Hong Cui
Keyword(s):  
Brain Injury ◽  
Rat Model ◽  
Ischemic Brain Injury ◽  
Immature Rat ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury

scholarly journals The role of oxidative stress in perinatal hypoxic-ischemic brain injury

2012 ◽  
Vol 140 (1-2) ◽  
pp. 35-41 ◽  
Author(s):  
Brankica Vasiljevic ◽  
Svjetlana Maglajlic-Djukic ◽  
Miroslava Gojnic ◽  
Sanja Stankovic
Keyword(s):  
Oxidative Stress ◽  
Brain Injury ◽  
Brain Damage ◽  
Ischemic Brain Injury ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury ◽  
Gpx Activity ◽  
Neurodevelopment Outcome

Introduction. The pathogenesis of perinatal hypoxic-ischemic brain damage is highly complex. Objective. The aim of this study was to assess the role of oxidative stress in hypoxic-ischemic brain injury and subsequent abnormal neurological outcome in infants with perinatal hypoxic-ischemic encephalopathy (HIE). We estimated perinatal oxidative brain damage measuring activity of glutathione peroxidase (GPX) in cerebrospinal fluid (CSF) as an indirect biomarker of free radical production during cerebral hypoxia-ischemia in correlation with the level of intracellular enzyme neuron specific enolase (NSE) in CSF as a biomarker of extend of brain injury. Methods. Ninety neonates (>32 GA) with perinatal HIE were enrolled prospectively. HIE was categorized into three stages according Sarnat and Sarnat clinical scoring system and changes seen on amplitude integrated EEG. CSF for GPX analysis and NSE analysis was taken in the first 72 hours of life. Neurodevelopment outcome was assessed at 12 months of corrected gestational age. Results. GPX activity in CSF was in good relation with clinical stage of HIE (p<0.0001) and GA (p<0.0001) and significantly corresponded with subsequent neurodevelopment outcome (p<0.001). GPX activity in CSF showed a strong correlation with NSE levels in CSF (p<0.001) as the biomarker of extent of brain injury. Conclusion. Our results suggest that oxidative stress might be important contributing factor in perinatal hypoxic-ischemic brain damage, particularly in preterm neonates.

scholarly journals Role of immunoglobulin in neuronal apoptosis in a neonatal rat model of hypoxic ischemic brain injury

2014 ◽  
Vol 7 (3) ◽  
pp. 734-738 ◽  
Author(s):  
SALIH KALAY ◽  
OSMAN ÖZTEKIN ◽  
GÖNÜL TEZEL ◽  
HAKAN ALDEMIR ◽  
EMEL SAHIN ◽  
...  
Keyword(s):  
Brain Injury ◽  
Rat Model ◽  
Neuronal Apoptosis ◽  
Neonatal Rat ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury ◽  
Neonatal Rat Model

scholarly journals Neuroprotection of N-benzyl Eicosapentaenamide in Neonatal Mice Following Hypoxic–Ischemic Brain Injury

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3108
Author(s):  
Mengya Jiao ◽  
Qun Dong ◽  
Yiting Zhang ◽  
Min Lin ◽  
Wan Zhou ◽  
...  
Keyword(s):  
Brain Injury ◽  
Neuronal Damage ◽  
Neuronal Cell ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Lepidium Meyenii ◽  
Neonatal Mice ◽  
Phosphorylated Akt ◽  
Medicinal Properties ◽  
Hypoxic Ischemic Brain Injury

Maca (Lepidium meyenii) has emerged as a popular functional plant food because of its medicinal properties and nutritional value. Macamides, as the exclusively active ingredients found in maca, are a unique series of non-polar, long-chain fatty acid N-benzylamides with multiple bioactivities such as antifatigue characteristics and improving reproductive health. In this study, a new kind of macamide, N-benzyl eicosapentaenamide (NB-EPA), was identified from maca. We further explore its potential neuroprotective role in hypoxic–ischemic brain injury. Our findings indicated that treatment with biosynthesized NB-EPA significantly alleviates the size of cerebral infarction and improves neurobehavioral disorders after hypoxic–ischemic brain damage in neonatal mice. NB-EPA inhibited the apoptosis of neuronal cells after ischemic challenge. NB-EPA improved neuronal cell survival and proliferation through the activation of phosphorylated AKT signaling. Of note, the protective property of NB-EPA against ischemic neuronal damage was dependent on suppression of the p53–PUMA pathway. Taken together, these findings suggest that NB-EPA may represent a new neuroprotectant for newborns with hypoxic–ischemic encephalopathy.

The Role of the Growth Factors IGF-1 and TGF?1after Hypoxic-Ischemic Brain Injury

1995 ◽  
Vol 765 (1 Neuroprotecti) ◽  
pp. 306-307 ◽  
Author(s):  
CHRIS WILLIAMS ◽  
JIAN GUAN ◽  
ODETTE MILLER ◽  
ERICA BEILHARZ ◽  
HEATHER MCNEILL ◽  
...  
Keyword(s):  
Growth Factors ◽  
Brain Injury ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury
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