scholarly journals Insights into the role of iron in immature rat model of hypoxic-ischemic brain injury

2016 ◽  
Vol 12 (3) ◽  
pp. 1723-1731
Author(s):  
Zi-Wei Wang ◽  
Li-Jun Yang ◽  
Ying-Xue Ding ◽  
Yan-Zhong Chang ◽  
Hong Cui
Keyword(s):  
Brain Injury ◽  
Rat Model ◽  
Ischemic Brain Injury ◽  
Immature Rat ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury

scholarly journals Role of immunoglobulin in neuronal apoptosis in a neonatal rat model of hypoxic ischemic brain injury

2014 ◽  
Vol 7 (3) ◽  
pp. 734-738 ◽  
Author(s):  
SALIH KALAY ◽  
OSMAN ÖZTEKIN ◽  
GÖNÜL TEZEL ◽  
HAKAN ALDEMIR ◽  
EMEL SAHIN ◽  
...  
Keyword(s):  
Brain Injury ◽  
Rat Model ◽  
Neuronal Apoptosis ◽  
Neonatal Rat ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury ◽  
Neonatal Rat Model

The role of trapidil on neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury

2008 ◽  
Vol 84 (4) ◽  
pp. 243-247 ◽  
Author(s):  
Aytug Atici ◽  
Gulcin Bozlu ◽  
Ali Haydar Turhan ◽  
Ayse Polat ◽  
Ali Nayci ◽  
...  
Keyword(s):  
Brain Injury ◽  
Rat Model ◽  
Neuronal Apoptosis ◽  
Neonatal Rat ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury ◽  
Neonatal Rat Model

Protective effects of FGF10 on neurovascular unit in a rat model of neonatal hypoxic-ischemic brain injury

2020 ◽  
Vol 332 ◽  
pp. 113393
Author(s):  
Mingchu Fang ◽  
Shishuang Jiang ◽  
Jianghu Zhu ◽  
Xiaoqin Fu ◽  
Yingying Hu ◽  
...  
Keyword(s):  
Brain Injury ◽  
Rat Model ◽  
Neurovascular Unit ◽  
Ischemic Brain Injury ◽  
Protective Effects ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury

scholarly journals A rat model of severe neonatal hypoxic-ischemic brain injury.

Stroke ◽  
1992 ◽  
Vol 23 (4) ◽  
pp. 539-546 ◽  
Author(s):  
P H Schwartz ◽  
W F Massarweh ◽  
H V Vinters ◽  
C G Wasterlain
Keyword(s):  
Brain Injury ◽  
Rat Model ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury

scholarly journals The role of oxidative stress in perinatal hypoxic-ischemic brain injury

2012 ◽  
Vol 140 (1-2) ◽  
pp. 35-41 ◽  
Author(s):  
Brankica Vasiljevic ◽  
Svjetlana Maglajlic-Djukic ◽  
Miroslava Gojnic ◽  
Sanja Stankovic
Keyword(s):  
Oxidative Stress ◽  
Brain Injury ◽  
Brain Damage ◽  
Ischemic Brain Injury ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury ◽  
Gpx Activity ◽  
Neurodevelopment Outcome

Introduction. The pathogenesis of perinatal hypoxic-ischemic brain damage is highly complex. Objective. The aim of this study was to assess the role of oxidative stress in hypoxic-ischemic brain injury and subsequent abnormal neurological outcome in infants with perinatal hypoxic-ischemic encephalopathy (HIE). We estimated perinatal oxidative brain damage measuring activity of glutathione peroxidase (GPX) in cerebrospinal fluid (CSF) as an indirect biomarker of free radical production during cerebral hypoxia-ischemia in correlation with the level of intracellular enzyme neuron specific enolase (NSE) in CSF as a biomarker of extend of brain injury. Methods. Ninety neonates (>32 GA) with perinatal HIE were enrolled prospectively. HIE was categorized into three stages according Sarnat and Sarnat clinical scoring system and changes seen on amplitude integrated EEG. CSF for GPX analysis and NSE analysis was taken in the first 72 hours of life. Neurodevelopment outcome was assessed at 12 months of corrected gestational age. Results. GPX activity in CSF was in good relation with clinical stage of HIE (p<0.0001) and GA (p<0.0001) and significantly corresponded with subsequent neurodevelopment outcome (p<0.001). GPX activity in CSF showed a strong correlation with NSE levels in CSF (p<0.001) as the biomarker of extent of brain injury. Conclusion. Our results suggest that oxidative stress might be important contributing factor in perinatal hypoxic-ischemic brain damage, particularly in preterm neonates.

53: Successful transnasal delivery of stem cells in a rat model of perinatal hypoxic-ischemic brain injury

2015 ◽  
Vol 212 (1) ◽  
pp. S38
Author(s):  
Byron Oppliger ◽  
Martin Müller ◽  
Marianne Jörger-Messerli ◽  
Ursula Reinhart ◽  
Andreina Schoeberlein ◽  
...  
Keyword(s):  
Stem Cells ◽  
Brain Injury ◽  
Rat Model ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury

The effect of levetiracetam on neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury

2013 ◽  
Vol 89 (5) ◽  
pp. 355-360 ◽  
Author(s):  
Hasan Kilicdag ◽  
Kenan Daglıoglu ◽  
Seyda Erdogan ◽  
Aslan Guzel ◽  
Leman Sencar ◽  
...  
Keyword(s):  
Brain Injury ◽  
Rat Model ◽  
Neuronal Apoptosis ◽  
Neonatal Rat ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury ◽  
Neonatal Rat Model

Erythropoietin exerts neuroprotective effect in neonatal rat model of hypoxic–ischemic brain injury

2003 ◽  
Vol 25 (7) ◽  
pp. 494-498 ◽  
Author(s):  
Adem Aydin ◽  
Kursad Genc̨ ◽  
Mustafa Akhisaroglu ◽  
Kutsal Yorukoglu ◽  
Necati Gokmen ◽  
...  
Keyword(s):  
Brain Injury ◽  
Rat Model ◽  
Neuroprotective Effect ◽  
Neonatal Rat ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury ◽  
Neonatal Rat Model
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