Diffusion Entropy: A Potential Neuroimaging Biomarker of Bipolar Disorder in the Temporal Pole

Karl Spuhler; Elizabeth Bartlett; Jie Ding; Christine DeLorenzo; Ramin Parsey; Chuan Huang

doi:10.1002/syn.22015

Diffusion Entropy: A Potential Neuroimaging Biomarker of Bipolar Disorder in the Temporal Pole

Synapse ◽

10.1002/syn.22015 ◽

2017 ◽

Vol 72 (2) ◽

pp. e22015 ◽

Cited By ~ 5

Author(s):

Karl Spuhler ◽

Elizabeth Bartlett ◽

Jie Ding ◽

Christine DeLorenzo ◽

Ramin Parsey ◽

...

Keyword(s):

Bipolar Disorder ◽

Diffusion Entropy ◽

Temporal Pole

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Abnormal Early Gamma Responses to Emotional Faces Differentiate Unipolar from Bipolar Disorder Patients

BioMed Research International ◽

10.1155/2014/906104 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 4

Author(s):

T. Y. Liu ◽

Y. S. Chen ◽

T. P. Su ◽

J. C. Hsieh ◽

L. F. Chen

Keyword(s):

Bipolar Disorder ◽

Early Stage ◽

Bipolar Disorders ◽

Gamma Oscillations ◽

Gamma Activity ◽

Depression Symptoms ◽

Emotional Faces ◽

Temporal Pole ◽

The Right ◽

Normal Controls

This study investigates the cortical abnormalities of early emotion perception in patients with major depressive disorder (MDD) and bipolar disorder (BD) using gamma oscillations. Twenty-three MDD patients, twenty-five BD patients, and twenty-four normal controls were enrolled and their event-related magnetoencephalographic responses were recorded during implicit emotional tasks. Our results demonstrated abnormal gamma activity within 100 ms in the emotion-related regions (amygdala, orbitofrontal (OFC) cortex, anterior insula (AI), and superior temporal pole) in the MDD patients, suggesting that these patients may have dysfunctions or negativity biases in perceptual binding of emotional features at very early stage. Decreased left superior medial frontal cortex (smFC) responses to happy faces in the MDD patients were correlated with their serious level of depression symptoms, indicating that decreased smFC activity perhaps underlies irregular positive emotion processing in depressed patients. In the BD patients, we showed abnormal activation in visual regions (inferior/middle occipital and middle temporal cortices) which responded to emotional faces within 100 ms, supporting that the BD patients may hyperactively respond to emotional features in perceptual binding. The discriminant function of gamma activation in the left smFC, right medial OFC, right AI/inferior OFC, and the right precentral cortex accurately classified 89.6% of patients as unipolar/bipolar disorders.

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933. Entropy Analysis Shows Temporal Pole Diffusivity Changes in Bipolar Disorder

Biological Psychiatry ◽

10.1016/j.biopsych.2017.02.659 ◽

2017 ◽

Vol 81 (10) ◽

pp. S377-S378

Author(s):

Karl Spuhler ◽

Christine DeLorenzo ◽

Ramin Parsey ◽

Chuan Huang

Keyword(s):

Bipolar Disorder ◽

Entropy Analysis ◽

Temporal Pole

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Genome-wide DNA methylomic differences between dorsolateral prefrontal and temporal pole cortices of bipolar disorder

Journal of Psychiatric Research ◽

10.1016/j.jpsychires.2019.05.030 ◽

2019 ◽

Vol 117 ◽

pp. 45-54 ◽

Cited By ~ 5

Author(s):

Ada M.-C. Ho ◽

Stacey J. Winham ◽

Sebastian M. Armasu ◽

Caren J. Blacker ◽

Vincent Millischer ◽

...

Keyword(s):

Bipolar Disorder ◽

Genome Wide ◽

Temporal Pole ◽

Dorsolateral Prefrontal

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Distinct Associations of Cognitive Impairments and Reduced Gray Matter Volumes in Remitted Patients with Schizophrenia and Bipolar Disorder

Neural Plasticity ◽

10.1155/2020/8859388 ◽

2020 ◽

Vol 2020 ◽

pp. 1-9

Author(s):

Ting Sun ◽

Pengfei Zhao ◽

Xiaowei Jiang ◽

Yifang Zhou ◽

Chao Li ◽

...

Keyword(s):

Bipolar Disorder ◽

Working Memory ◽

Gray Matter ◽

Right Hemisphere ◽

Cognitive Impairments ◽

Anterior Cingulate ◽

First Episode ◽

Temporal Pole ◽

The Right ◽

Gray Matter Volumes

Background. Cognitive impairments are documented in schizophrenia (SZ) and bipolar disorder (BD) and may be related to gray matter volumes (GMVs). Thus, this study is aimed at exploring whether the association between cognitive impairments and GMV alterations is similar in patients with SZ and BD and understanding the underlying neurobiological mechanisms. Methods. A total of 137 adult subjects (46 with SZ, 35 with BD, and 56 age-, sex-, and education-matched healthy controls (HC)) completed the MATRICS Consensus Cognitive Battery (MCCB) and structural magnetic resonance imaging scanning. We performed group comparisons of the cognitive impairments, the GMV alterations, and the association between them. Results. Compared with HC, the patients with SZ and BD showed shared deficits in 4 cognitive domains (i.e., processing speed, working memory, problem solving, and social cognition) and the composite. SZ and BD had commonly decreased GMVs, mainly in the insula, superior temporal pole, amygdala, anterior cingulate, and frontal cortices (superior, middle, opercular inferior, and orbital frontal gyrus). No correlation between MCCB scores and GMVs was detected in SZ. However, for BD, working memory was relevant to the right hemisphere (i.e., right insula, amygdala, superior temporal pole, and medial and dorsolateral superior frontal gyrus). Limitations. The major limitations were that not all patients were the first-episode status and no medication. Conclusions. The association was mainly limited to the BD group. Thus, the underlying pathophysiology of the cognitive deficits, in terms of GMV alterations, may be diverse between two disorders.

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