Effects of gabapentin on brain hyperactivity related to pain and sleep disturbance under a neuropathic pain-like state using fMRI and brain wave analysis

Synapse ◽  
2011 ◽  
Vol 65 (7) ◽  
pp. 668-676 ◽  
Author(s):  
Yoshinori Takemura ◽  
Akira Yamashita ◽  
Hiroshi Horiuchi ◽  
Masaharu Furuya ◽  
Makoto Yanase ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Sleep Disturbance ◽  
Wave Analysis ◽  
Brain Wave

Brain wave analysis in advertising research. Validation from basic research & independent replications

1984 ◽  
Vol 1 (3-4) ◽  
pp. 83-95 ◽  
Author(s):  
Sidney Weinstein ◽  
Ronald Drozdenko ◽  
Curt Weinstein
Keyword(s):  
Basic Research ◽  
Advertising Research ◽  
Wave Analysis ◽  
Brain Wave

Patient perspectives

2010 ◽  
pp. 181-187
Author(s):  
S. Jos Closs
Keyword(s):  
Quality Of Life ◽  
Neuropathic Pain ◽  
Suicidal Ideation ◽  
Side Effects ◽  
Focus Group ◽  
Drug Treatment ◽  
Sleep Disturbance ◽  
Focus Group Research ◽  
The Impact

The impact of neuropathic pain on quality of life has been under-researched and poorly understood though survey and focus group research is helping to gain better insights into what patients suffer Neuropathic pain can result in significant sleep disturbance, fatigue, and low mood (that sometimes leads to suicidal ideation), and side-effects from drug treatment are common...

scholarly journals Usefulness of Olanzapine as an Adjunct to Opioid Treatment and for the Treatment of Neuropathic Pain

2012 ◽  
Vol 116 (1) ◽  
pp. 159-169 ◽  
Author(s):  
Kazuhiro Torigoe ◽  
Kae Nakahara ◽  
Mahardian Rahmadi ◽  
Kazumi Yoshizawa ◽  
Hiroshi Horiuchi ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Neuropathic Pain ◽  
Sleep Disturbance ◽  
Brain Tissue ◽  
Gastrointestinal Transit ◽  
Thermal Hyperalgesia ◽  
Nausea And Vomiting ◽  
Dependent Manner ◽  
Antiemetic Effect

Background The use of opioids for pain management is often associated with nausea and vomiting. Although conventional antipsychotics are often used to counter emesis, they can be associated with extrapyramidal symptoms. However, chronic pain can induce sleep disturbance. The authors investigated the effects of the atypical antipsychotic olanzapine on morphine-induced emesis and the sleep dysregulation associated with chronic pain. Methods A receptor binding assay was performed using mouse whole brain tissue. The emetic response in ferrets was evaluated by counting retching and vomiting behaviors. Catalepsy in mice was evaluated by placing both of their forepaws over a horizontal bar. Released dopamine was measured by an in vivo microdialysis study. Sleep disturbance in mice in a neuropathic pain-like state was assayed by electroencephalogram and electromyogram recordings. Results Olanzapine showed high affinity for muscarinic M1 receptor in brain tissue. Olanzapine decreased morphine-induced nausea and vomiting in a dose-dependent manner. However, olanzapine at a dose that had an antiemetic effect (0.03 mg/kg) did not induce catalepsy or hyperglycemia. In addition, olanzapine at this dose had no effect on the morphine-induced release of dopamine or inhibition of gastrointestinal transit. Finally, olanzapine inhibited thermal hyperalgesia and completely alleviated the sleep disturbance induced by sciatic nerve ligation. Conclusion These findings suggest that olanzapine may be useful for the treatment of morphine-induced emesis and as an adjunct for the treatment of neuropathic pain associated with sleep disturbance.

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