Relationship between in vitro tumor stem cell assay and in vivo antitumor activity using the p388 leukemia

1988 ◽  
Vol 6 (1) ◽  
pp. 60-68 ◽  
Author(s):  
John C. Marsh ◽  
Robert H. Shoemaker ◽  
David H. Kern ◽  
John M. Venditti
Keyword(s):  
Stem Cell ◽  
Antitumor Activity ◽  
Tumor Stem Cell ◽  
P388 Leukemia ◽  
Cell Assay ◽  
In Vivo Antitumor Activity ◽  
Tumor Stem Cell Assay

scholarly journals Quantitative association between the in vitro human tumor stem cell assay and clinical response to cancer chemotherapy

1981 ◽  
Vol 6 (3) ◽  
Author(s):  
ThomasE. Moon ◽  
SydneyE. Salmon ◽  
CarolynS. White ◽  
H-S.George Chen ◽  
FrankL. Meyskens ◽  
...  
Keyword(s):  
Stem Cell ◽  
Clinical Response ◽  
Cancer Chemotherapy ◽  
Human Tumor ◽  
Tumor Stem Cell ◽  
Cell Assay ◽  
Tumor Stem Cell Assay

Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin

2014 ◽  
Vol 74 ◽  
pp. 742-750 ◽  
Author(s):  
Chengyuan Liang ◽  
Juan Xia ◽  
Dong Lei ◽  
Xiang Li ◽  
Qizheng Yao ◽  
...  
Keyword(s):  
Schiff Base ◽  
Antitumor Activity ◽  
Schiff Base Derivatives ◽  
In Vivo Antitumor Activity ◽  
Derivatives Of

Human colorectal carcinoma: Patterns of sensitivity to chemotherapeutic agents in the human tumor stem cell assay

1982 ◽  
Vol 20 (3) ◽  
pp. 187-191 ◽  
Author(s):  
Michael V. Agrez ◽  
John S. Kovach ◽  
Robert W. Beart ◽  
Joseph Rubin ◽  
Charles G. Moertel ◽  
...  
Keyword(s):  
Stem Cell ◽  
Colorectal Carcinoma ◽  
Human Tumor ◽  
Chemotherapeutic Agents ◽  
Tumor Stem Cell ◽  
Cell Assay ◽  
Tumor Stem Cell Assay ◽  
Human Colorectal Carcinoma

scholarly journals Design, synthesis and pharmacological evaluation of novel 2-chloro-3-(1H-benzo[d]imidazol-2-yl)quinoline derivatives as antitumor agents: in vitro and in vivo antitumor activity, cell cycle arrest and apoptotic response

RSC Advances ◽  
2018 ◽  
Vol 8 (43) ◽  
pp. 24376-24385 ◽  
Author(s):  
Wen-Bin Kuang ◽  
Ri-Zhen Huang ◽  
Yi-Lin Fang ◽  
Gui-Bin Liang ◽  
Chen-Hui Yang ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Antitumor Agents ◽  
Quinoline Derivatives ◽  
Apoptotic Response ◽  
Design Synthesis ◽  
Cycle Arrest ◽  
In Vivo Antitumor Activity ◽  
Combination Principle

A series of novel 2-chloro-3-(1H-benzo[d]imidazol-2-yl)quinoline derivatives were designed and synthesized as antitumor agents under the combination principle. The antitumor activity and mechanisms were then evaluated.

„IN VITRO“ AND „IN VIVO“ ANTITUMOR ACTIVITY OF PLATINUM(II) COMPLEXES WITH MALONIC ACID ON BREAST AND COLORECTAL CARCINOMA CELL LINES

2021 ◽  
Author(s):  
Andjela Franich ◽  
◽  
Milica Dimitrijević Stojanović ◽  
Snežana Rajković ◽  
Marina Jovanović ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Colorectal Carcinoma ◽  
Cell Lines ◽  
Tumor Model ◽  
Carcinoma Cells ◽  
Spectroscopic Techniques ◽  
Murine Cell Line ◽  
In Vivo Antitumor Activity

Four Pt(II) complexes of the general formula [Pt(L)(5,6-epoxy-1,10-phen)], where L is anion of malonic (mal, Pt1), 2-methylmalonic (Me-mal, Pt2), 2,2-dimethylmalonic (Me2-mal, Pt3) or 1,1- cyclobutanedicarboxylic (CBDCA, Pt4) acid while 5,6-epoxy-1,10-phen is bidentately coordinated 5,6-epoxy-5,6-dihydro-1,10-phenanthroline were synthesized and characterized by elemental microanalysis, IR, UV-Vis and NMR (1H and 13C) spectroscopic techniques. In vitro anticancer activity of novel platinum(II) complexes have been investigated on human and murine cancer cell lines, as well as normal murine cell line by MTT assay. The obtained results indicate that studied platinum(II) complexes exhibited strong cytotoxic activity against murine breast carcinoma cells (4T1), human (HCT116) and murine (CT26) colorectal carcinoma cells. Complex Pt3 display stronger selectivity toward carcinoma cells in comparison to other tested platinum(II) complexes exhibiting beneficial antitumor activity mainly via the induction of apoptosis, as well as inhibition of cell proliferation and migration. Further study showed that Pt3 complex also carry significant in vivo antitumor activity in orthotopical 4T1 tumor model without detected liver, kidney, lung, and heart toxicity. All results imply that these novel platinum(II) complexes have a good anti-tumor effect on breast and colorectal cancer in vivo and in vitro and the affinity to become possible candidates for treatment in anticancer therapy.

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