scholarly journals Ephb3 Inhibits the Expansion of Neural Progenitor Cells in the SVZ by Regulating p53 During Homeostasis and Following Traumatic Brain Injury

Stem Cells ◽  
2010 ◽  
pp. N/A-N/A ◽  
Author(s):  
Michelle H Theus ◽  
Jerome Ricard ◽  
John R Bethea ◽  
Daniel J Liebl
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor

scholarly journals Transplantation of Neural Progenitor Cells within Hyaluronic Acid Hydrogel in Traumatic Brain Injury in Experiment

2017 ◽  
Vol 9 (4) ◽  
pp. 106 ◽  
Author(s):  
A.V. Balyabin ◽  
O.P. Tikhobrazova ◽  
A.A. Gladkov ◽  
M.S. Muravyova ◽  
Y.A. Klyuyev ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Hyaluronic Acid ◽  
Brain Injury ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Hyaluronic Acid Hydrogel

scholarly journals TNF-α Pretreatment Improves the Survival and Function of Transplanted Human Neural Progenitor Cells Following Hypoxic-Ischemic Brain Injury

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1195
Author(s):  
Miri Kim ◽  
Kwangsoo Jung ◽  
Younhee Ko ◽  
Il-Sun Kim ◽  
Kyujin Hwang ◽  
...  
Keyword(s):  
Brain Injury ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Infarct Volume ◽  
Fetal Brain ◽  
Neural Progenitor ◽  
Great Promise ◽  
Therapeutic Effects ◽  
Ischemic Brain ◽  
Tnf Α

Neural progenitor cells (NPCs) therapy offers great promise in hypoxic-ischemic (HI) brain injury. However, the poor survival of implanted NPCs in the HI host environment limits their therapeutic effects. Tumor necrosis factor-alpha (TNF-α) is a pleiotropic cytokine that is induced in response to a variety of pathological processes including inflammation and immunity. On the other hand, TNF-α has protective effects on cell apoptosis and death and affects the differentiation, proliferation, and survival of neural stem/progenitor cells in the brain. The present study investigated whether TNF-α pretreatment on human NPCs (hNPCs) enhances the effectiveness of cell transplantation therapy under ischemic brain. Fetal brain tissue-derived hNPCs were pretreated with TNF-α before being used in vitro experiments or transplantation. TNF-α significantly increased expression of cIAP2, and the use of short hairpin RNA-mediated knockdown of cIAP2 demonstrated that cIAP2 protected hNPCs against HI-induced cytotoxicity. In addition, pretreatment of hNPCs with TNF-α mediated neuroprotection by altering microglia polarization via increased expression of CX3CL1 and by enhancing expression of neurotrophic factors. Furthermore, transplantation of TNF-α-treated hNPCs reduced infarct volume and improved neurological functions in comparison with non-pretreated hNPCs or vehicle. These findings show that TNF-α pretreatment, which protects hNPCs from HI-injured brain-induced apoptosis and increases neuroprotection, is a simple and safe approach to improve the survival of transplanted hNPCs and the therapeutic efficacy of hNPCs in HI brain injury.

Sign in / Sign up

Export Citation Format

Share Document