scholarly journals Erratum: Corrigendum: Synergy of endothelial and neural progenitor cells from adipose-derived stem cells to preserve neurovascular structures in rat hypoxic-ischemic brain injury

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yuan-Yu Hsueh ◽  
Ya-Ju Chang ◽  
Chia-Wei Huang ◽  
Fitri Handayani ◽  
Yi-Lun Chiang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Brain Injury ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Ischemic Brain Injury ◽  
Adipose Derived Stem Cells ◽  
Ischemic Brain ◽  
Hypoxic Ischemic Brain Injury ◽  
Neurovascular Structures

scholarly journals 364: Neuroregenerative functions of transnasal delivered umbilical cord stem cells in a model of preterm hypoxic-ischemic brain injury

2016 ◽  
Vol 214 (1) ◽  
pp. S203-S204
Author(s):  
Byron Oppliger ◽  
Marianne Jörger-Messerli ◽  
Martin Müller ◽  
Ursula Reinhart ◽  
Philipp Schneider ◽  
...  
Keyword(s):  
Stem Cells ◽  
Brain Injury ◽  
Umbilical Cord ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Umbilical Cord Stem Cells ◽  
Hypoxic Ischemic Brain Injury

scholarly journals TNF-α Pretreatment Improves the Survival and Function of Transplanted Human Neural Progenitor Cells Following Hypoxic-Ischemic Brain Injury

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1195
Author(s):  
Miri Kim ◽  
Kwangsoo Jung ◽  
Younhee Ko ◽  
Il-Sun Kim ◽  
Kyujin Hwang ◽  
...  
Keyword(s):  
Brain Injury ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Infarct Volume ◽  
Fetal Brain ◽  
Neural Progenitor ◽  
Great Promise ◽  
Therapeutic Effects ◽  
Ischemic Brain ◽  
Tnf Α

Neural progenitor cells (NPCs) therapy offers great promise in hypoxic-ischemic (HI) brain injury. However, the poor survival of implanted NPCs in the HI host environment limits their therapeutic effects. Tumor necrosis factor-alpha (TNF-α) is a pleiotropic cytokine that is induced in response to a variety of pathological processes including inflammation and immunity. On the other hand, TNF-α has protective effects on cell apoptosis and death and affects the differentiation, proliferation, and survival of neural stem/progenitor cells in the brain. The present study investigated whether TNF-α pretreatment on human NPCs (hNPCs) enhances the effectiveness of cell transplantation therapy under ischemic brain. Fetal brain tissue-derived hNPCs were pretreated with TNF-α before being used in vitro experiments or transplantation. TNF-α significantly increased expression of cIAP2, and the use of short hairpin RNA-mediated knockdown of cIAP2 demonstrated that cIAP2 protected hNPCs against HI-induced cytotoxicity. In addition, pretreatment of hNPCs with TNF-α mediated neuroprotection by altering microglia polarization via increased expression of CX3CL1 and by enhancing expression of neurotrophic factors. Furthermore, transplantation of TNF-α-treated hNPCs reduced infarct volume and improved neurological functions in comparison with non-pretreated hNPCs or vehicle. These findings show that TNF-α pretreatment, which protects hNPCs from HI-injured brain-induced apoptosis and increases neuroprotection, is a simple and safe approach to improve the survival of transplanted hNPCs and the therapeutic efficacy of hNPCs in HI brain injury.

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