scholarly journals Aryl hydrocarbon receptor controls skin homeostasis, regeneration, and hair follicle cycling by adjusting epidermal stem cell function

Stem Cells ◽  
2021 ◽  
Author(s):  
Eva María Rico‐Leo ◽  
Luis Francisco Lorenzo‐Martín ◽  
Ángel Carlos Román ◽  
Xosé Ramón Bustelo ◽  
Jaime María Merino ◽  
...  
Keyword(s):  
Stem Cell ◽  
Aryl Hydrocarbon Receptor ◽  
Hair Follicle ◽  
Cell Function ◽  
Epidermal Stem Cell ◽  
Aryl Hydrocarbon

scholarly journals Architectural Niche Organization by LHX2 is Linked to Hair Follicle Stem Cell Function

2014 ◽  
Vol 20 (S3) ◽  
pp. 1382-1383 ◽  
Author(s):  
H. Amalia Pasolli ◽  
Alicia R. Folgueras ◽  
Elaine Fuchs
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Cell Function ◽  
Hair Follicle Stem Cell

scholarly journals Architectural Niche Organization by LHX2 Is Linked to Hair Follicle Stem Cell Function

2013 ◽  
Vol 13 (3) ◽  
pp. 314-327 ◽  
Author(s):  
Alicia R. Folgueras ◽  
Xingyi Guo ◽  
H. Amalia Pasolli ◽  
Nicole Stokes ◽  
Lisa Polak ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Cell Function ◽  
Hair Follicle Stem Cell

scholarly journals Indoleamine 2, 3-Dioxygenase Promotes Aryl Hydrocarbon Receptor-Dependent Differentiation Of Regulatory B Cells in Lung Cancer

2021 ◽  
Vol 12 ◽  
Author(s):  
Sultan Tousif ◽  
Yong Wang ◽  
Joshua Jackson ◽  
Kenneth P. Hough ◽  
John G. Strenkowski ◽  
...  
Keyword(s):  
Lung Cancer ◽  
B Cells ◽  
Aryl Hydrocarbon Receptor ◽  
Cell Function ◽  
Metabolic Enzyme ◽  
Dependent Manner ◽  
Regulatory B Cells ◽  
Indoleamine 2 ◽  
Aryl Hydrocarbon ◽  
Syngeneic Mouse Model

Regulatory B cells (Breg) are IL-10 producing subsets of B cells that contribute to immunosuppression in the tumor microenvironment (TME). Breg are elevated in patients with lung cancer; however, the mechanisms underlying Breg development and their function in lung cancer have not been adequately elucidated. Herein, we report a novel role for Indoleamine 2, 3- dioxygenase (IDO), a metabolic enzyme that degrades tryptophan (Trp) and the Trp metabolite L-kynurenine (L-Kyn) in the regulation of Breg differentiation in the lung TME. Using a syngeneic mouse model of lung cancer, we report that Breg frequencies significantly increased during tumor progression in the lung TME and secondary lymphoid organs, while Breg were reduced in tumor-bearing IDO deficient mice (IDO-/-). Trp metabolite L-Kyn promoted Breg differentiation in-vitro in an aryl hydrocarbon receptor (AhR), toll-like receptor-4-myeloid differentiation primary response 88, (TLR4-MyD88) dependent manner. Importantly, using mouse models with conditional deletion of IDO in myeloid-lineage cells, we identified a significant role for immunosuppressive myeloid-derived suppressor cell (MDSC)-associated IDO in modulating in-vivo and ex-vivo differentiation of Breg. Our studies thus identify Trp metabolism as a therapeutic target to modulate regulatory B cell function during lung cancer progression.

scholarly journals Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Hye-Min Kim ◽  
Ji-Woo Kim ◽  
Youngjun Choi ◽  
Hang-Suk Chun ◽  
Ilkyun Im ◽  
...  
Keyword(s):  
Stem Cell ◽  
Aryl Hydrocarbon Receptor ◽  
Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell ◽  
Aryl Hydrocarbon
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