scholarly journals Architectural Niche Organization by LHX2 Is Linked to Hair Follicle Stem Cell Function

2013 ◽  
Vol 13 (3) ◽  
pp. 314-327 ◽  
Author(s):  
Alicia R. Folgueras ◽  
Xingyi Guo ◽  
H. Amalia Pasolli ◽  
Nicole Stokes ◽  
Lisa Polak ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Cell Function ◽  
Hair Follicle Stem Cell

scholarly journals Architectural Niche Organization by LHX2 is Linked to Hair Follicle Stem Cell Function

2014 ◽  
Vol 20 (S3) ◽  
pp. 1382-1383 ◽  
Author(s):  
H. Amalia Pasolli ◽  
Alicia R. Folgueras ◽  
Elaine Fuchs
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Cell Function ◽  
Hair Follicle Stem Cell

scholarly journals The anti‐apoptotic Bcl‐2 protein regulates hair follicle stem cell function

EMBO Reports ◽  
2021 ◽  
Author(s):  
Anna Geueke ◽  
Giada Mantellato ◽  
Florian Kuester ◽  
Peter Schettina ◽  
Melanie Nelles ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Cell Function ◽  
Hair Follicle Stem Cell

scholarly journals State-dependent signaling by Cav1.2 regulates hair follicle stem cell function

2013 ◽  
Vol 27 (11) ◽  
pp. 1217-1222 ◽  
Author(s):  
G. Yucel ◽  
B. Altindag ◽  
N. Gomez-Ospina ◽  
A. Rana ◽  
G. Panagiotakos ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hair Follicle ◽  
Cell Function ◽  
State Dependent ◽  
Hair Follicle Stem Cell

scholarly journals Transcription Factor DLX5 Promotes Hair Follicle Stem Cell Differentiation by Regulating the c-MYC/microRNA-29c-3p/NSD1 Axis

2021 ◽  
Vol 9 ◽  
Author(s):  
Bojie Lin ◽  
Jiangying Zhu ◽  
Guoqian Yin ◽  
Mingde Liao ◽  
Guanyu Lin ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Stem Cell ◽  
Hair Follicle ◽  
Promoter Region ◽  
Cell Function ◽  
Adult Stem Cell ◽  
Stem Cell Differentiation ◽  
Model Systems ◽  
Hair Follicle Stem Cell

IntroductionAdult stem cell function has been one of the most intensively explored areas of biological and biomedical research, with hair follicle stem cells serving as one of the best model systems. This study explored the role of the transcription factor DLX5 in regulating hair follicle stem cell (HFSC) differentiation.MethodsHFSCs were isolated, characterized, and assessed for their expression of DLX5, c-MYC, NSD1, and miR-29c-3p using RT-qPCR, Western blot analysis, or immunofluorescence. Next, the ability of HFSCs to proliferate as well as differentiate into either sebaceous gland cells or epidermal cells was determined. The binding of DLX5 to the c-MYC promoter region, the binding of c-MYC to the miR-29c-3p promoter region, and the binding of miR-29c-3p to the 3′-UTR of NSD1 mRNA were verified by luciferase activity assay and ChIP experiments.ResultsDLX5 was highly expressed in differentiated HFSCs. DLX5 transcriptionally activated c-MYC expression to induce HFSC differentiation. c-MYC was able to bind the miR-29c-3p promoter and thus suppressed its expression. Without miR-29c-3p mediated suppression, NSD1 was then able to promote HFSC differentiation. These in vitro experiments suggested that DLX5 could promote HFSC differentiation via the regulation of the c-MYC/miR-29c-3p/NSD1 axis.DiscussionThis study demonstrates that DLX5 promotes HFSC differentiation by modulating the c-MYC/miR-29c-3p/NSD1 axis and identifies a new mechanism regulating HFSC differentiation.

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