scholarly journals Concise Review: Amniotic Fluid Stem Cells: The Known, the Unknown, and Potential Regenerative Medicine Applications

Stem Cells ◽  
2017 ◽  
Vol 35 (7) ◽  
pp. 1663-1673 ◽  
Author(s):  
Stavros P. Loukogeorgakis ◽  
Paolo De Coppi
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Amniotic Fluid ◽  
Amniotic Fluid Stem Cells ◽  
Concise Review

scholarly journals Amniotic Fluid Stem Cells: A New Era in Regenerative Medicine

2017 ◽  
Vol 68 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Mala Srivastava ◽  
Neha Ahlawat ◽  
Ankita Srivastava
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Amniotic Fluid ◽  
New Era ◽  
Amniotic Fluid Stem Cells

scholarly journals Stem cells in the amniotic fluid: the new chance of regenerative medicine

2011 ◽  
Vol 152 (15) ◽  
pp. 581-587 ◽  
Author(s):  
József Gábor Joó
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Amniotic Fluid ◽  
Diagnostic Tool ◽  
Congenital Malformations ◽  
Genetic Diseases ◽  
Storage Diseases ◽  
Amniotic Fluid Stem Cells ◽  
Amniotic Fluid Stem Cell ◽  
Near Future

Amniotic fluid has been used in prenatal diagnosis for more than decades. It yields a simple and reliable screening and diagnostic tool for a variety of congenital malformations and genetic diseases such as chromosomal aberrations, neural tube defects or storage diseases. Nowadays the widening knowledge provides evidence that amniotic fluid is not only a screening and diagnostic tool, but it may be also the source of the effective therapy of several congenital and adult disorders. A subset of cells, the so-called stem cells were found in the amniotic fluid as well as the placenta, and they proved to be capable of maintaining prolonged undifferentiated proliferation. Stem cells are able to differentiate into multiple tissue types, originating from the three germ layers. In the near future stem cells isolated from amniotic fluid or placenta and stored by cryopreservation may play a significant role in regenerative medicine. Congenital malformations as well as certain diseases in adults might be treated by tissues coming from progenitor cells of amniotic fluid stem cell origin. This study gives a summary of the main characteristics of amniotic fluid stem cells and it also presents important examples of their possible clinical application. Orv. Hetil., 2011, 152, 581–587.

scholarly journals Unravelling Heterogeneity of Amplified Human Amniotic Fluid Stem Cells Sub-Populations

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 158
Author(s):  
Francesca Casciaro ◽  
Silvia Zia ◽  
Mattia Forcato ◽  
Manuela Zavatti ◽  
Francesca Beretti ◽  
...  
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Amniotic Fluid ◽  
New Technology ◽  
Enrichment Analysis ◽  
Gene Set Enrichment Analysis ◽  
Label Free ◽  
Human Amniotic Fluid ◽  
Significant Differential Expression ◽  
Amniotic Fluid Stem Cells

Human amniotic fluid stem cells (hAFSCs) are broadly multipotent immature progenitor cells with high self-renewal and no tumorigenic properties. These cells, even amplified, present very variable morphology, density, intracellular composition and stemness potential, and this heterogeneity can hinder their characterization and potential use in regenerative medicine. Celector® (Stem Sel ltd.) is a new technology that exploits the Non-Equilibrium Earth Gravity Assisted Field Flow Fractionation principles to characterize and label-free sort stem cells based on their solely physical characteristics without any manipulation. Viable cells are collected and used for further studies or direct applications. In order to understand the intrapopulation heterogeneity, various fractions of hAFSCs were isolated using the Celector® profile and live imaging feature. The gene expression profile of each fraction was analysed using whole-transcriptome sequencing (RNAseq). Gene Set Enrichment Analysis identified significant differential expression in pathways related to Stemness, DNA repair, E2F targets, G2M checkpoint, hypoxia, EM transition, mTORC1 signalling, Unfold Protein Response and p53 signalling. These differences were validated by RT-PCR, immunofluorescence and differentiation assays. Interestingly, the different fractions showed distinct and unique stemness properties. These results suggest the existence of deep intra-population differences that can influence the stemness profile of hAFSCs. This study represents a proof-of-concept of the importance of selecting certain cellular fractions with the highest potential to use in regenerative medicine.

Therapeutic Potential of Amniotic Fluid Stem Cells

2013 ◽  
Vol 8 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Hassan Abdulrazzak ◽  
Paolo De Coppi ◽  
Pascale V Guillot
Keyword(s):  
Stem Cells ◽  
Amniotic Fluid ◽  
Therapeutic Potential ◽  
Amniotic Fluid Stem Cells

Amniotic fluid stem cells ameliorate bladder dysfunction induced by chronic bladder ischemia in rat

2017 ◽  
Vol 37 (1) ◽  
pp. 123-131 ◽  
Author(s):  
Ching‐Chung Liang ◽  
Sheng‐Wen Steven Shaw ◽  
Yi‐Hao Lin ◽  
Tsong‐Hai Lee
Keyword(s):  
Stem Cells ◽  
Amniotic Fluid ◽  
Bladder Dysfunction ◽  
Amniotic Fluid Stem Cells ◽  
Bladder Ischemia

scholarly journals Amniotic Fluid Stem Cells

10.5772/24085 ◽  
2011 ◽  
Author(s):  
Gianni Carraro ◽  
Orquidea H. ◽  
Laura Perin ◽  
Roger De ◽  
David Warburto
Keyword(s):  
Stem Cells ◽  
Amniotic Fluid ◽  
Amniotic Fluid Stem Cells

Amniotic Fluid Stem Cells for the Treatment of Articular Cartilage Defects

2014 ◽  
pp. 87-97
Author(s):  
Andrea Preitschopf ◽  
Julia Busch ◽  
Hannes Zwickl ◽  
Stefan Nehrer ◽  
Markus Hengstschläger ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Amniotic Fluid ◽  
Cartilage Defects ◽  
Amniotic Fluid Stem Cells ◽  
Articular Cartilage Defects

scholarly journals Effect of Amniotic Fluid Stem Cells and Amniotic Fluid Cells on the Wound Healing Process in a White Rat Model

2013 ◽  
Vol 40 (5) ◽  
pp. 496 ◽  
Author(s):  
Jung Dug Yang ◽  
Dong Sik Choi ◽  
Young Kyoo Cho ◽  
Taek Kyun Kim ◽  
Jeong Woo Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Amniotic Fluid ◽  
Rat Model ◽  
Healing Process ◽  
Wound Healing Process ◽  
Amniotic Fluid Stem Cells ◽  
Amniotic Fluid Cells
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