Amniotic fluid stem cells ameliorate bladder dysfunction induced by chronic bladder ischemia in rat

2017 ◽  
Vol 37 (1) ◽  
pp. 123-131 ◽  
Author(s):  
Ching‐Chung Liang ◽  
Sheng‐Wen Steven Shaw ◽  
Yi‐Hao Lin ◽  
Tsong‐Hai Lee
Keyword(s):  
Stem Cells ◽  
Amniotic Fluid ◽  
Bladder Dysfunction ◽  
Amniotic Fluid Stem Cells ◽  
Bladder Ischemia

scholarly journals Amniotic Fluid Stem Cells Improve Rat Bladder Dysfunction After Pelvic Nerve Transection

2020 ◽  
Vol 29 ◽  
pp. 096368972090938
Author(s):  
Ching-Chung Liang ◽  
Sheng-Wen Steven Shaw ◽  
Hung-Hsueh Chou ◽  
Yung-Hsin Huang ◽  
Tsong-Hai Lee
Keyword(s):  
Stem Cells ◽  
Amniotic Fluid ◽  
Bladder Dysfunction ◽  
Bladder Capacity ◽  
Sham Operation ◽  
Nerve Transection ◽  
Sprague Dawley ◽  
Pelvic Nerve ◽  
Sham Operation Group ◽  
Amniotic Fluid Stem Cells

The effects of human amniotic fluid stem cells (hAFSCs) transplantation on bladder dysfunction after pelvic nerve transection (PNT) remain to be clarified. Five groups of female Sprague-Dawley rats were studied including sham operation, unilateral PNT alone or plus hAFSCs transplantation, and bilateral PNT alone or plus hAFSCs transplantation. hAFSCs were injected at the site of PNT. Cystometries, neurofilament density within bladder nerves, and the expressions of bladder protein gene-product 9.5 (PGP9.5), growth-associated protein 43 (GAP-43), nerve growth factor (NGF), p75 (NGF receptor), CXCL12, CCL7, and enkephalin were studied. Compared to sham-operation group, bladder weight increased and neurofilament density decreased at 10 and 28 days after unilateral and bilateral PNT, but all improved after hAFSCs transplantation. Unilateral PNT could increase bladder capacity, residual volume, and number of nonvoiding contractions but decrease peak voiding pressure and leak point pressure. Bilateral PNT caused overflow incontinence and increased the number of nonvoiding contractions. These cystometric parameters improved after hAFSCs transplantation. After PNT, bladder PGP9.5 mRNA and immunoreactivities decreased at 10 and 28 days, GAP-43 mRNA and immunoreactivities increased at 10 days and decreased at 28 days, both NGF and p75 mRNAs and immunoreactivities increased at 10 and/or 28 days, and enkephalin immunoreactivities decreased at 10 and 28 days, but these were all improved after hAFSCs transplantation. Our results showed that bladder dysfunction induced by PNT could be improved by hAFSCs transplantation, and PGP9.5, GAP-43, and neurotrophins could be involved in the mechanisms of nerve regeneration after hAFSCs transplantation.

scholarly journals Improvement in bladder dysfunction after bladder transplantation of amniotic fluid stem cells in diabetic rats

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Ching-Chung Liang ◽  
Sheng-Wen Steven Shaw ◽  
Yung-Hsin Huang ◽  
Yi-Hao Lin ◽  
Tsong-Hai Lee
Keyword(s):  
Stem Cells ◽  
Amniotic Fluid ◽  
Bladder Dysfunction ◽  
Diabetic Rats ◽  
Amniotic Fluid Stem Cells

Therapeutic Potential of Amniotic Fluid Stem Cells

2013 ◽  
Vol 8 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Hassan Abdulrazzak ◽  
Paolo De Coppi ◽  
Pascale V Guillot
Keyword(s):  
Stem Cells ◽  
Amniotic Fluid ◽  
Therapeutic Potential ◽  
Amniotic Fluid Stem Cells

scholarly journals Amniotic Fluid Stem Cells

10.5772/24085 ◽  
2011 ◽  
Author(s):  
Gianni Carraro ◽  
Orquidea H. ◽  
Laura Perin ◽  
Roger De ◽  
David Warburto
Keyword(s):  
Stem Cells ◽  
Amniotic Fluid ◽  
Amniotic Fluid Stem Cells

Amniotic Fluid Stem Cells for the Treatment of Articular Cartilage Defects

2014 ◽  
pp. 87-97
Author(s):  
Andrea Preitschopf ◽  
Julia Busch ◽  
Hannes Zwickl ◽  
Stefan Nehrer ◽  
Markus Hengstschläger ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Amniotic Fluid ◽  
Cartilage Defects ◽  
Amniotic Fluid Stem Cells ◽  
Articular Cartilage Defects

scholarly journals Effect of Amniotic Fluid Stem Cells and Amniotic Fluid Cells on the Wound Healing Process in a White Rat Model

2013 ◽  
Vol 40 (5) ◽  
pp. 496 ◽  
Author(s):  
Jung Dug Yang ◽  
Dong Sik Choi ◽  
Young Kyoo Cho ◽  
Taek Kyun Kim ◽  
Jeong Woo Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Amniotic Fluid ◽  
Rat Model ◽  
Healing Process ◽  
Wound Healing Process ◽  
Amniotic Fluid Stem Cells ◽  
Amniotic Fluid Cells

Amniotic Fluid Stem Cells for Kidney Regeneration

2018 ◽  
pp. 85-95
Author(s):  
Valentina Villani ◽  
Astgik Petrosyan ◽  
Roger E. De Filippo ◽  
Stefano Da Sacco
Keyword(s):  
Stem Cells ◽  
Amniotic Fluid ◽  
Kidney Regeneration ◽  
Amniotic Fluid Stem Cells

scholarly journals Biological characterization and pluripotent identification of ovine amniotic fluid stem cells

2018 ◽  
Vol 70 (3) ◽  
pp. 1009-1021
Author(s):  
Wenhua Pei ◽  
Tengfei Lu ◽  
Kunfu Wang ◽  
Meng Ji ◽  
Shuang Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Amniotic Fluid ◽  
Biological Characterization ◽  
Amniotic Fluid Stem Cells
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