scholarly journals Protein Kinase-A Inhibition Is Sufficient to Support Human Neural Stem Cells Self-Renewal

Stem Cells ◽  
2015 ◽  
Vol 33 (12) ◽  
pp. 3666-3672 ◽  
Author(s):  
Pauline Georges ◽  
Claire Boissart ◽  
Aurélie Poulet ◽  
Marc Peschanski ◽  
Alexandra Benchoua
Keyword(s):  
Stem Cells ◽  
Protein Kinase ◽  
Neural Stem Cells ◽  
Protein Kinase A ◽  
Self Renewal ◽  
Human Neural Stem Cells ◽  
Kinase A

The Balance Between Self-Renewal and Differentiation of Human Neural Stem Cells Requires the Amyloid Precursor Protein

2021 ◽  
Author(s):  
Khadijeh Shabani ◽  
Julien Pigeon ◽  
Marwan Benaissa Touil Zariouh ◽  
Tengyuan Liu ◽  
Azadeh Saffarian ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Self Renewal ◽  
Human Neural Stem Cells

scholarly journals L- MYC Expression Maintains Self-Renewal and Prolongs Multipotency of Primary Human Neural Stem Cells

2016 ◽  
Vol 7 (3) ◽  
pp. 483-495 ◽  
Author(s):  
Zhongqi Li ◽  
Diana Oganesyan ◽  
Rachael Mooney ◽  
Xianfang Rong ◽  
Matthew J. Christensen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Self Renewal ◽  
Human Neural Stem Cells

scholarly journals Activation of Protein Kinase A and Exchange Protein Directly Activated by cAMP Promotes Adipocyte Differentiation of Human Mesenchymal Stem Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e34114 ◽  
Author(s):  
Bingbing Jia ◽  
Lise Madsen ◽  
Rasmus Koefoed Petersen ◽  
Nathalie Techer ◽  
Reidun Kopperud ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Adipocyte Differentiation ◽  
Human Mesenchymal Stem Cells ◽  
Kinase A ◽  
Exchange Protein

Heparin-mediated electrostatic immobilization of bFGF via functional polymer films for enhanced self-renewal of human neural stem cells

2021 ◽  
Author(s):  
Younghak Cho ◽  
Jieung Baek ◽  
Eunjung Lee ◽  
Sung Gap Im
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Electrostatic Interaction ◽  
Polymer Films ◽  
Copolymer Film ◽  
Self Renewal ◽  
Functional Polymer ◽  
Human Neural Stem Cells

A novel copolymer film of pGMA-co-DMAEMA is generated to modulate the electrostatic interaction with heparin, thereby facilitating bFGF immobilization. hNSCs cultured on this surface exhibited enhanced stemness-related properties and neurogenesis.

Protein Kinase A Signaling Is Inhibitory for Reprogramming into Pluripotent Stem Cells

2016 ◽  
Vol 25 (5) ◽  
pp. 378-385 ◽  
Author(s):  
Jong Soo Kim ◽  
Yean Ju Hong ◽  
Hyun Woo Choi ◽  
Sol Choi ◽  
Jeong Tae Do
Keyword(s):  
Stem Cells ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Pluripotent Stem Cells ◽  
Kinase A

scholarly journals Aberrant Expression of Circulating MicroRNA Leads to the Dysregulation of Alpha-Synuclein and Other Pathogenic Genes in Parkinson’s Disease

2021 ◽  
Vol 9 ◽  
Author(s):  
Meng Cai ◽  
Songshan Chai ◽  
Tao Xiong ◽  
Jun Wei ◽  
Weibing Mao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Protein Kinase ◽  
Neural Stem Cells ◽  
Regulatory Network ◽  
Target Genes ◽  
Alpha Synuclein ◽  
Related Gene ◽  
Human Neural Stem Cells

A group of circulating microRNAs (miRNAs) have been implicated in the pathogenesis of Parkinson’s disease. However, a comprehensive study of the interactions between pathogenic miRNAs and their downstream Parkinson’s disease (PD)-related target genes has not been performed. Here, we identified the miRNA expression profiles in the plasma and circulating exosomes of Parkinson’s disease patients using next-generation RNA sequencing. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses showed that the miRNA target genes were enriched in axon guidance, neurotrophin signaling, cellular senescence, and the Transforming growth factor-β (TGF-β), mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)-protein kinase B (AKT) and mechanistic target of rapamycin (mTOR) signaling pathways. Furthermore, a group of aberrantly expressed miRNAs were selected and further validated in individual patient plasma, human neural stem cells (NSCs) and a rat model of PD. More importantly, the full scope of the regulatory network between these miRNAs and their PD-related gene targets in human neural stem cells was examined, and the findings revealed a similar but still varied downstream regulatory cascade involving many known PD-associated genes. Additionally, miR-23b-3p was identified as a novel direct regulator of alpha-synuclein, which is possibly the key component in PD. Our current study, for the first time, provides a glimpse into the regulatory network of pathogenic miRNAs and their PD-related gene targets in PD. Moreover, these PD-associated miRNAs may serve as biomarkers and novel therapeutic targets for PD.

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