The effect of chemically-modified resistant starch, RS type-4, on body weight and blood lipid profiles of high fat diet-induced obese mice

The effect of the extract of Ligustrum lucidum fruits (LFE) and its major secoiridoid (LFS), (8- E)-nüzhenide, on obesity was investigated using high fat-diet (HFD)-induced C58BL/6J obese mice. LFE and LFS were administered at the doses of 300 mg/kg and 30 mg/kg, respectively, for 6 weeks. The anti-obesity activity was evaluated by measuring body weight, epididymal fat and metabolic plasma parameters. On Day 42, the body weight of the LFS-treated group was significantly lower compared with the HFD-treated group. Body weight gain was also reduced by 23.2% and 32.0% in the LFE- and LFS-treated groups, respectively, compared with the HFD group. In addition, the weight of the epididymal fat in the mice was significantly decreased in the HFD+LFS group. The food efficiency ratios (FERs) of the HFD+LFE and HFD+LFS groups were also lower compared with the HFD group with the same food intake. Metabolic parameters that had increased in the HFD group were decreased in the HFD+LFE and HFD+LFS groups. In particular, the increased triglyceride values were significantly reduced in the HFD+LFS group. These results show that treatment with LFE and LFS decreased HFD-induced obesity, mainly by improving metabolic parameters, such as fats and triglycerides. Therefore, LFE and LFS have potential benefits in regulation of obesity.

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HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice

BMC Complementary and Alternative Medicine ◽

10.1186/1472-6882-14-505 ◽

2014 ◽

Vol 14 (1) ◽

Cited By ~ 4

Author(s):

Heon-Myung Lee ◽

Hong-Kun Rim ◽

Jong-Hwan Seo ◽

Yoon-Bum Kook ◽

Sung-Kew Kim ◽

...

Keyword(s):

Gene Expression ◽

Body Weight ◽

Weight Gain ◽

High Fat Diet ◽

Body Weight Gain ◽

Obese Mice ◽

Related Gene ◽

High Fat

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Erchen Decoction Prevents High-Fat Diet Induced Metabolic Disorders in C57BL/6 Mice

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2015/501272 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9 ◽

Cited By ~ 7

Author(s):

Bi-Zhen Gao ◽

Ji-Cheng Chen ◽

Ling-Hong Liao ◽

Jia-Qi Xu ◽

Xiao-Feng Lin ◽

...

Keyword(s):

Body Weight ◽

High Fat Diet ◽

Cell Function ◽

Blood Lipid ◽

Abdominal Circumference ◽

High Fat ◽

Medicine Prescription ◽

Chinese Medicine Prescription ◽

Treatment Of Obesity ◽

Islet Cell Function

Erchen decoction (ECD) is a traditional Chinese medicine prescription, which is used in the treatment of obesity, hyperlipidemia, fatty liver, diabetes, hypertension, and other diseases caused by retention of phlegm dampness. In this study we investigated the potential mechanism of ECD, using metabolism-disabled mice induced by high-fat diet. Body weight and abdominal circumference were detected. OGTT was measured by means of collecting blood samples from the tail vein. Blood lipid levels and insulin were measured using biochemical assay kit. Real-time PCR was used to measure the CDKAL1 gene expression and western blot was used to measure the protein expression. Through the research, it was found that ECD showed markedly lower body weight and abdominal circumference than those in the HFD group. Consistently, we observed that ECD significantly improved glucose tolerance, promoted the secretion of insulin and decreased the level of TG, TC level. Meanwhile, we observed significantly increased CDKAL1 mRNA and protein level in the ECD group. Therefore, we speculate that the potential molecular mechanism of ECD is to promote the CDKAL1 expression, ameliorate islet cell function, and raise insulin levels to regulate the metabolic disorder.

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Angelica sinensis Suppresses Body Weight Gain and Alters Expression of the FTO Gene in High-Fat-Diet Induced Obese Mice

BioMed Research International ◽

10.1155/2017/6280972 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 4

Author(s):

Tao Zhong ◽

Xiao-Yue Duan ◽

Hao Zhang ◽

Li Li ◽

Hong-Ping Zhang ◽

...

Keyword(s):

Body Weight ◽

High Fat Diet ◽

Cpg Island ◽

Body Weight Gain ◽

Methylation Status ◽

Normal Diet ◽

Angelica Sinensis ◽

Obese Mouse ◽

Obese Mice ◽

High Fat

The root of Angelica sinensis (RAS) is a traditional Chinese medicine used for preventing and treating various diseases. In this study, we assessed RAS supplementation effects on body weight and the FTO gene expression and methylation status in a high-fat-diet (HFD) induced obese mouse model. Female obese mice were divided into groups according to RAS dosage in diet as follows: normal diet, HFD diet (HC), HFD with low-dosage RAS (DL), HFD with medium-dosage RAS (DM), and HFD with high-dosage RAS (DH). After RAS supplementation for 4 weeks, body weight suppression and FTO expression in DH mice were significantly higher than in HC mice, whereas no significant change in FTO expression was detected between DM and DL mice or in their offspring. Bisulfite sequencing PCR (BSP) revealed that the CpG island in the FTO promoter was hypermethylated up to 95.44% in the HC group, 91.67% in the DH group, and 90.00% in the normal diet group. Histological examination showed that adipocytes in the DH group were smaller than those in the HC group, indicating a potential role of RAS in obesity. This study indicated that RAS could ameliorate obesity induced by HFD and that the molecular mechanism might be associated with the expression of the FTO gene.

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