Stability indicating LC method for estimation of Valbenazine and its degradation kinetic study

2020 ◽  
Vol 3 (4) ◽  
pp. 94-101
Author(s):  
Payal J. Parmar ◽  
Vandana B. Patel ◽  
Dimal A. Shah
Keyword(s):  
Kinetic Study ◽  
Degradation Kinetic ◽  
Stability Indicating

Stability-indicating UHPLC method for determination of nevirapine in its bulk form and tablets: identification of impurities and degradation kinetic study

2016 ◽  
Vol 126 ◽  
pp. 103-108 ◽  
Author(s):  
Naialy Fernandes Araújo Reis ◽  
Jéssica Camille de Assis ◽  
Sílvia Ligório Fialho ◽  
Gerson Antônio Pianetti ◽  
Christian Fernandes
Keyword(s):  
Kinetic Study ◽  
Degradation Kinetic ◽  
Stability Indicating

scholarly journals Validation of Stability Indicating Method and Degradation Kinetic Study of Apremilast

2020 ◽  
Vol 10 (2) ◽  
pp. 76-85
Author(s):  
Jitesha Patel ◽  
Parin Chokshi ◽  
Rajashree Mashru
Keyword(s):  
Kinetic Study ◽  
Hplc Method ◽  
Forced Degradation ◽  
Order Kinetic ◽  
Degradation Kinetic ◽  
Degradation Study ◽  
Potassium Dihydrogen ◽  
Stability Indicating ◽  
Stability Indicating Method ◽  
Rp Hplc

A novel stability indicating RP- HPLC method was developed for the estimation of Apremilast in bulk and marketed formulation. Separation was achieved by using Shimadzu HPLC Analytical Technologies Limited C18 (250 mm x 4.6 mm, 5µm) as stationary phase. The optimized mobile phase consist of potassium dihydrogen ortho phosphate (pH-3.2): acetonitrile in ratio of 40:60 %v/v with flow rate of 1mL/min by using methanol as diluent. Retention time of Apremilast was found to be 5.4 min which was estimated at wavelength 360nm. Linearity of Apremilast was observed in the concentration range of 50-400µg/mL with r² value of 0.9999. Assay of Apremilast tablet was found to be 99.14-100.75%. Stability indicating nature of RP- HPLC method was estimated by conducting degradation kinetic study. The forced degradation of Apremilast bulk indicate that degradation in acidic, alkali, oxidative and photolysis condition were found to be 21%, 6.5%, 25.7% and 3.9% respectively. The kinetic study of apremilast in alkali degradation followed first order kinetic study. The result indicate that the developed RP-HPLC method is suitable for estimation of Apremilast in presence of degradant product. The above method was validated as per ICH guideline. Keywords: Apremilast, RP-HPLC, Validation, Forced Degradation Study, Alkali Degradation Kinetic study

Hydrolytic Degradation Kinetic Study of Balofloxacin by Stability Indicating Reversed Phase High Performance Liquid Chromatography Method

2016 ◽  
Vol 7 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Bhavin Pankajbhai Marolia ◽  
Pintu Bhagwanbhai Prajapati ◽  
Kunjan Bharatbhai Bodiwala ◽  
Megha Pravinkumar Vaghela ◽  
Shailesh Amritlal Shah ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Kinetic Study ◽  
High Performance ◽  
Hydrolytic Degradation ◽  
Reversed Phase ◽  
Chromatography Method ◽  
Degradation Kinetic ◽  
Stability Indicating ◽  
Liquid Chromatography Method
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