scholarly journals Fabrication of Multiresponsive Magnetic Nanocomposite Double‐Network Hydrogels for Controlled Release Applications (Small 52/2021)

Small ◽  
2021 ◽  
Vol 17 (52) ◽  
pp. 2170275
Author(s):  
Cheng‐Hsun Lu ◽  
Yi‐Cheun Yeh
Keyword(s):  
Controlled Release ◽  
Magnetic Nanocomposite ◽  
Double Network

Selective De-Cross-Linking of Transformable, Double-Network Hydrogels: Preparation, Structural Conversion, and Controlled Release

2018 ◽  
Vol 10 (49) ◽  
pp. 42985-42991 ◽  
Author(s):  
Doyoung Jung ◽  
Kyoung Min Lee ◽  
Ji Young Chang ◽  
Misun Yun ◽  
Hak-Jong Choi ◽  
...  
Keyword(s):  
Controlled Release ◽  
Cross Linking ◽  
Structural Conversion ◽  
Double Network

Fabrication of smart magnetic nanocomposite asymmetric membrane capsules for the controlled release of nitrate

2017 ◽  
Vol 8 ◽  
pp. 233-243 ◽  
Author(s):  
Nahid Emami ◽  
Amir Razmjou ◽  
Fatemeh Noorisafa ◽  
Asghar Habibnejad Korayem ◽  
Ali Zarrabi ◽  
...  
Keyword(s):  
Controlled Release ◽  
Magnetic Nanocomposite ◽  
Asymmetric Membrane

Controlled release antibiotics for dry powder lung delivery

2009 ◽  
Vol 00 (00) ◽  
pp. 090805050810080-8 ◽  
Author(s):  
Handoko Adi ◽  
Paul Michael Young ◽  
Hak-Kim Chan ◽  
Rania Salama ◽  
Daniela Traini
Keyword(s):  
Controlled Release ◽  
Dry Powder ◽  
Lung Delivery

Effect of Crosslinking on the Network Parameters, Swelling and Mechanical Properties of PVA-Borax and Poly (AM-co-HEMA) Double Network (DN) Hydrogels

2019 ◽  
Vol 35 (3) ◽  
pp. 371-391
Author(s):  
AKANSHA DIXIT ◽  
◽  
DIBYENDU S. BAG ◽  
DHIRENDRA KUMAR SHARMA ◽  
HARJEET SINGH ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Double Network ◽  
Network Parameters

Controlled Release of Metformin Hydrochloride I. In vitro Release from Physical Mixture Containing Xanthan Gum as Hydrophilic Rate Retarding Polymer

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
Mashkura Ashrafi ◽  
Jakir Ahmed Chowdhury ◽  
Md Selim Reza
Keyword(s):  
Controlled Release ◽  
Xanthan Gum ◽  
In Vitro Release ◽  
Correlation Coefficients ◽  
High Ratio ◽  
Water Soluble ◽  
Metformin Hydrochloride ◽  
Model Drug ◽  
Very High

Capsules of different formulations were prepared by using a hydrophilic polymer, xanthan gum and a filler Ludipress. Metformin hydrochloride, which is an anti-diabetic agent, was used as a model drug here with the aim to formulate sustained release capsules. In the first 6 formulations, metformin hydrochloride and xanthan gum were used in different ratio. Later, Ludipress was added to the formulations in a percentage of 8% to 41%. The total procedure was carried out by physical mixing of the ingredients and filling in capsule shells of size ‘1’. As metformin hydrochloride is a highly water soluble drug, the dissolution test was done in 250 ml distilled water in a thermal shaker (Memmert) with a shaking speed of 50 rpm at 370C &plusmn 0.50C for 6 hours. After the dissolution, the data were treated with different kinetic models. The results found from the graphs and data show that the formulations follow the Higuchian release pattern as they showed correlation coefficients greater than 0.99 and the sustaining effect of the formulations was very high when the xanthan gum was used in a very high ratio with the drug. It was also investigated that the Ludipress extended the sustaining effect of the formulation to some extent. But after a certain period, Ludipress did not show any significant effect as the pores made by the xanthan gum network were already blocked. It is found here that when the metformin hydrochloride and the xanthan gum ratio was 1:1, showed a high percentage of drug release, i.e. 91.80% of drug was released after 6 hours. But With a xanthan gum and metformin hydrochloride ratio of 6:1, a very slow release of the drug was obtained. Only 66.68% of the drug was released after 6 hours. The percent loading in this case was 14%. Again, when Ludipress was used in high ratio, it was found to retard the release rate more prominently. Key words: Metformin Hydrochloride, Xanthan Gum, Controlled release capsule Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

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