Efficient Gene Therapy of Pancreatic Cancer via a Peptide Nucleic Acid (PNA)‐Loaded Layered Double Hydroxides (LDH) Nanoplatform

Small ◽  
2020 ◽  
Vol 16 (23) ◽  
pp. 1907233 ◽  
Author(s):  
Zhiguo Yu ◽  
Ping Hu ◽  
Yingying Xu ◽  
Qunqun Bao ◽  
Dalong Ni ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Gene Therapy ◽  
Nucleic Acid ◽  
Layered Double Hydroxides ◽  
Peptide Nucleic Acid ◽  
Efficient Gene ◽  
Double Hydroxides

An RNA/DNA hybrid origami-based nanoplatform for efficient gene therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Xiaohui Wu ◽  
Qing Liu ◽  
Fengsong Liu ◽  
Tiantian Wu ◽  
Yingxu Shang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Nucleic Acid ◽  
Homologous Gene ◽  
Target Mrna ◽  
Therapeutic Drugs ◽  
Efficient Gene

Nucleic acid nanostructures are promising biomaterials for the delivery of homologous gene therapeutic drugs. Herein, we report a facile strategy for the construction of target mRNA (scaffold) and antisenses (staple...

Hybrid nanotechnology and peptide nucleic acid could improve the effectiveness of gene therapy by increasing its cell permeability

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Carbon Nanotubes ◽  
Gene Therapy ◽  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Intracellular Delivery ◽  
Cell Permeability ◽  
Full Potential ◽  
Hybrid Nanotechnology ◽  
Insight Into ◽  
The Way

The utilization of nanoparticles and carbon nanotubes in PNA-based technologies has opened the way for the application of nanotechnology in oligonucleotide compilation. It is possible that further study may offer insight into how to improve the effectiveness of oligonucleotides by increasing their cell permeability. Because PNA accumulates within the cell when it is transported by a lipid-based carrier, it has insufficient cytosolic dispersion, which greatly limits its medicinal potential. This finding suggests that nanoparticles and nanostructures that are similar in appearance to carbon nanotubes can be employed to efficiently disseminate PNA. Innovative ways of intracellular delivery of PNA, such as the use of viruses and nutrients, will require significant and in-depth exploration before they can reach their full potential.

Radionuclide–Peptide Nucleic Acid in Diagnosis and Treatment of Pancreatic Cancer

2004 ◽  
pp. 135-192
Author(s):  
Eric Wickstrom ◽  
Xiaobing Tian ◽  
Nariman V. Amirkhanov ◽  
Atis Chakrabarti ◽  
Mohan R. Aruva ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Diagnosis And Treatment

Molecular insights on the dynamic stability of peptide nucleic acid functionalized carbon and boron nitride nanotubes

2021 ◽  
Vol 23 (1) ◽  
pp. 219-228
Author(s):  
Nabanita Saikia ◽  
Mohamed Taha ◽  
Ravindra Pandey
Keyword(s):  
Nucleic Acid ◽  
Boron Nitride ◽  
Nucleic Acids ◽  
Dynamic Stability ◽  
Peptide Nucleic Acid ◽  
Rational Design ◽  
Peptide Nucleic Acids ◽  
Boron Nitride Nanotubes ◽  
Molecular Hybrids ◽  
Single Wall Nanotubes

The rational design of self-assembled nanobio-molecular hybrids of peptide nucleic acids with single-wall nanotubes rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial's surface.

Acceptorless amine dehydrogenation and transamination using Pd-doped layered double hydroxides

2018 ◽  
Author(s):  
Diana Ainembabazi ◽  
Nan An ◽  
Jinesh Manayil ◽  
Kare Wilson ◽  
Adam Lee ◽  
...  
Keyword(s):  
Layered Double Hydroxides ◽  
Oxidation States ◽  
Secondary Amines ◽  
Primary Amines ◽  
Acid Dissolution ◽  
Oxidative Amination ◽  
Strong Function ◽  
Excellent Activity ◽  
High Yields ◽  
Double Hydroxides

<div> <p>The synthesis, characterization, and activity of Pd-doped layered double hydroxides (Pd-LDHs) for for acceptorless amine dehydrogenation is reported. These multifunctional catalysts comprise Brønsted basic and Lewis acidic surface sites that stabilize Pd species in 0, 2+, and 4+ oxidation states. Pd speciation and corresponding cataytic performance is a strong function of metal loading. Excellent activity is observed for the oxidative transamination of primary amines and acceptorless dehydrogenation of secondary amines to secondary imines using a low Pd loading (0.5 mol%), without the need for oxidants. N-heterocycles, such as indoline, 1,2,3,4-tetrahydroquinoline, and piperidine, are dehydrogenated to the corresponding aromatics with high yields. The relative yields of secondary imines are proportional to the calculated free energy of reaction, while yields for oxidative amination correlate with the electrophilicity of primary imine intermediates. Reversible amine dehydrogenation and imine hydrogenation determine the relative imine:amine selectivity. Poisoning tests evidence that Pd-LDHs operate heterogeneously, with negligible metal leaching; catalysts can be regenerated by acid dissolution and re-precipitation.</p> </div> <br>

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