Glutathione Depletion in a Benign Manner by MoS 2 ‐Based Nanoflowers for Enhanced Hypoxia‐Irrelevant Free‐Radical‐Based Cancer Therapy

Small ◽  
2019 ◽  
Vol 15 (51) ◽  
pp. 1904870 ◽  
Author(s):  
Si Wu ◽  
Xinping Liu ◽  
Jinsong Ren ◽  
Xiaogang Qu
Keyword(s):  
Free Radical ◽  
Cancer Therapy ◽  
Glutathione Depletion

scholarly journals NIR-II-driven and glutathione depletion-enhanced hypoxia-irrelevant free radical nanogenerator for combined cancer therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Li Zhang ◽  
Yadi Fan ◽  
Zhe Yang ◽  
Mo Yang ◽  
Chun-Yuen Wong
Keyword(s):  
Free Radical ◽  
Cancer Therapy ◽  
Contrast Agent ◽  
Near Infrared ◽  
Glutathione Depletion ◽  
Therapeutic Effects ◽  
Zeolitic Imidazolate Framework ◽  
Hypoxic Conditions ◽  
Light Excitation ◽  
4T1 Cells

Abstract Background Though the combination of photodynamic therapy (PDT) and chemodynamic therapy (CDT) appears to be very attractive in cancer treatment, hypoxia and overproduced glutathione (GSH) in the tumor microenvironment (TME) limit their efficacy for further application. Results In this work, a smart hypoxia-irrelevant free radical nanogenerator (AIPH/PDA@CuS/ZIF-8, denoted as APCZ) was synthesized in situ via coating copper sulphide (CuS)-embedded zeolitic imidazolate framework-8 (ZIF-8) on the free radical initiator 2,2′-azobis[2-(2-imidazolin-2-yl)propane]-dihydrochloride (AIPH)-loaded polydopamine (PDA). APCZ showed promising GSH-depleting ability and near-infrared (NIR)-II photothermal performance for combined cancer therapy. Once internalized by 4T1 cells, the outer ZIF-8 was rapidly degraded to trigger the release of CuS nanoparticles (NPs), which could react with local GSH and sequentially hydrogen peroxide (H2O2) to form hydroxyl radical (·OH) for CDT. More importantly, the hyperthermia generated by APCZ upon 1064 nm laser excitation not only permitted NIR-II photothermal therapy (PTT) and promoted CDT, but also triggered the decomposition of AIPH to give toxic alkyl radical (·R) for oxygen-independent PDT. Besides, the PDA together with CuS greatly decreased the GSH level and resulted in significantly enhanced PDT/CDT in both normoxic and hypoxic conditions. The tumors could be completely eradicated after 14 days of treatment due to the prominent therapeutic effects of PTT/PDT/CDT. Additionally, the feasibility of APCZ as a photoacoustic (PA) imaging contrast agent was also demonstrated. Conclusions The novel APCZ could realize the cooperative amplification effect of free radicals-based therapies by NIR-II light excitation and GSH consumption, and act as a contrast agent to improve PA imaging, holding tremendous potential for efficient diagnosis and treatment of deep-seated and hypoxic tumors. Graphic abstract

A simultaneously GSH-depleted bimetallic Cu(ii) complex for enhanced chemodynamic cancer therapy

2020 ◽  
Vol 49 (34) ◽  
pp. 11851-11858
Author(s):  
Shuhua Cao ◽  
Xuezhao Li ◽  
Yong Gao ◽  
Fahui Li ◽  
Kaoxue Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Glutathione Depletion

A bimetallic Cu(ii) complex was developed as a novel antitumor chemodynamic therapy agent with glutathione depletion properties.

Initiator-Loaded Gold Nanocages as a Light-Induced Free-Radical Generator for Cancer Therapy

2017 ◽  
Vol 56 (31) ◽  
pp. 9029-9033 ◽  
Author(s):  
Xiao-Qiang Wang ◽  
Fan Gao ◽  
Xian-Zheng Zhang
Keyword(s):  
Free Radical ◽  
Cancer Therapy ◽  
Gold Nanocages

Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Biomaterials ◽  
2021 ◽  
pp. 121110
Author(s):  
Boyi Niu ◽  
Kaixin Liao ◽  
Yixian Zhou ◽  
Ting Wen ◽  
Guilan Quan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Glutathione Depletion

Initiator-Loaded Gold Nanocages as a Light-Induced Free-Radical Generator for Cancer Therapy

2017 ◽  
Vol 129 (31) ◽  
pp. 9157-9161 ◽  
Author(s):  
Xiao-Qiang Wang ◽  
Fan Gao ◽  
Xian-Zheng Zhang
Keyword(s):  
Free Radical ◽  
Cancer Therapy ◽  
Gold Nanocages

Engineering nanomedicine for glutathione depletion-augmented cancer therapy

2021 ◽  
Author(s):  
Yuxuan Xiong ◽  
Chen Xiao ◽  
Zifu Li ◽  
Xiangliang Yang
Keyword(s):  
Cancer Therapy ◽  
Recent Progress ◽  
Glutathione Depletion ◽  
Intracellular Glutathione

In this review, we systematically survey the most recent progress in engineering nanomedicine for intracellular glutathione consumption-augmented cancer therapy.

Sign in / Sign up

Export Citation Format

Share Document