Engineering nanomedicine for glutathione depletion-augmented cancer therapy

2021 ◽  
Author(s):  
Yuxuan Xiong ◽  
Chen Xiao ◽  
Zifu Li ◽  
Xiangliang Yang
Keyword(s):  
Cancer Therapy ◽  
Recent Progress ◽  
Glutathione Depletion ◽  
Intracellular Glutathione

In this review, we systematically survey the most recent progress in engineering nanomedicine for intracellular glutathione consumption-augmented cancer therapy.

scholarly journals Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy

Biomedicines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 359
Author(s):  
Hsiang-Hao Chuang ◽  
Yen-Yi Zhen ◽  
Yu-Chen Tsai ◽  
Cheng-Hao Chuang ◽  
Ming-Shyan Huang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Suppressors ◽  
Protein Conformation ◽  
Genome Stability ◽  
Recent Progress ◽  
Multiple Roles ◽  
Cancer Development ◽  
Cancer Hallmarks ◽  
Underlying Mechanisms ◽  
And Function

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in cancers and plays an important role in tumorigenesis. Mounting evidence has revealed that targeting Pin1 is a potential therapeutic approach for various cancers by inhibiting cell proliferation, reducing metastasis, and maintaining genome stability. In this review, we summarize the underlying mechanisms of Pin1-mediated upregulation of oncogenes and downregulation of tumor suppressors in cancer development. Furthermore, we also discuss the multiple roles of Pin1 in cancer hallmarks and examine Pin1 as a desirable pharmaceutical target for cancer therapy. We also summarize the recent progress of Pin1-targeted small-molecule compounds for anticancer activity.

scholarly journals Personalized Medicine: Recent Progress in Cancer Therapy

Cancers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 242
Author(s):  
Ann Hoeben ◽  
Elbert A. J. Joosten ◽  
Marieke H. J. van den Beuken-van Everdingen
Keyword(s):  
Cancer Therapy ◽  
Personalized Medicine ◽  
Precision Medicine ◽  
Recent Progress ◽  
Tumor Treatment ◽  
Treatment And Prevention

Personalized medicine (PM) or precision medicine in oncology is an emerging approach for tumor treatment and prevention that takes into account inter- and intra-tumor variability in genes, tumor (immune) environment, and lifestyle and morbidities of each person diagnosed with cancer [...]

scholarly journals Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhen Luo ◽  
Yujuan Gao ◽  
Zhongyu Duan ◽  
Yu Yi ◽  
Hao Wang
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Self Assembly ◽  
Recent Progress ◽  
Assembly Systems ◽  
Targeted Cancer Therapy ◽  
Cancer Treatments ◽  
Self Assembling ◽  
Stimuli Response

Mitochondria are well known to serve as the powerhouse for cells and also the initiator for some vital signaling pathways. A variety of diseases are discovered to be associated with the abnormalities of mitochondria, including cancers. Thus, targeting mitochondria and their metabolisms are recognized to be promising for cancer therapy. In recent years, great efforts have been devoted to developing mitochondria-targeted pharmaceuticals, including small molecular drugs, peptides, proteins, and genes, with several molecular drugs and peptides enrolled in clinical trials. Along with the advances of nanotechnology, self-assembled peptide-nanomaterials that integrate the biomarker-targeting, stimuli-response, self-assembly, and therapeutic effect, have been attracted increasing interest in the fields of biotechnology and nanomedicine. Particularly, in situ mitochondria-targeted self-assembling peptides that can assemble on the surface or inside mitochondria have opened another dimension for the mitochondria-targeted cancer therapy. Here, we highlight the recent progress of mitochondria-targeted peptide-nanomaterials, especially those in situ self-assembly systems in mitochondria, and their applications in cancer treatments.

Recent progress of nanomedicine-induced ferroptosis for cancer therapy

2021 ◽  
Author(s):  
Hajra Zafar ◽  
Faisal Raza ◽  
Siyu Ma ◽  
Yawen Wei ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Recent Progress ◽  
Treatment Strategies ◽  
Current Treatment ◽  
High Efficacy ◽  
Innovative Therapies

The current treatment strategies for cancer therapy have posed many problems in achieving high efficacy. Therefore, an urgent step is needed to develop innovative therapies that can win beyond satisfactory...

Recent progress in utilizing near-infrared J-aggregates for imaging and cancer therapy

2021 ◽  
Author(s):  
Shuai Xu ◽  
Hong-Wen Liu ◽  
Shuang-Yan Huan ◽  
Lin Yuan ◽  
Xiao-Bing Zhang
Keyword(s):  
Cancer Therapy ◽  
Recent Progress ◽  
Near Infrared ◽  
Organic Dyes ◽  
Therapeutic Agents ◽  
Schematic Diagram ◽  
J Aggregates

Schematic diagram of NIR J-aggregates of various organic dyes as effective bioimaging (fluorescence (FL) or photoacoustic (PA)) and therapeutic agents (PDT or PTT).

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