Anticipating Cutoff Diameters in Deterministic Lateral Displacement (DLD) Microfluidic Devices for an Optimized Particle Separation

Small ◽  
2017 ◽  
Vol 13 (37) ◽  
pp. 1701901 ◽  
Author(s):  
Eloise Pariset ◽  
Catherine Pudda ◽  
François Boizot ◽  
Nicolas Verplanck ◽  
Jean Berthier ◽  
...  
Keyword(s):  
Lateral Displacement ◽  
Particle Separation ◽  
Microfluidic Devices ◽  
Deterministic Lateral Displacement

scholarly journals Electrokinetically driven deterministic lateral displacement for particle separation in microfluidic devices

2014 ◽  
Vol 18 (5-6) ◽  
pp. 1195-1200 ◽  
Author(s):  
Srinivas Hanasoge ◽  
Raghavendra Devendra ◽  
Francisco J. Diez ◽  
German Drazer
Keyword(s):  
Lateral Displacement ◽  
Particle Separation ◽  
Microfluidic Devices ◽  
Deterministic Lateral Displacement

Limits of Parabolic Flow Theory in Microfluidic Particle Separation: A Computational Study

2013 ◽  
Author(s):  
Ryan S. Pawell ◽  
Tracie J. Barber ◽  
David W. Inglis ◽  
Robert A. Taylor
Keyword(s):  
Computational Study ◽  
Lateral Displacement ◽  
Particle Separation ◽  
Flow Profile ◽  
Flow Rates ◽  
Deterministic Lateral Displacement ◽  
Flow Development ◽  
Separation Threshold ◽  
Parabolic Flow ◽  
Size Based Separation

Microfluidic particle separation technologies are useful for enriching rare cell populations for academic and clinical purposes. In order to separate particles based on size, deterministic lateral displacement (DLD) arrays are designed assuming that the flow profile between posts is parabolic or shifted parabolic (depending on post geometry). The design process also assumes the shape of the normalized flow profile is speed-invariant. The work presented here shows flow profile shapes vary, in arrays with circular and triangular posts, from this assumption at practical flow rates (10 < Re < 100). The root-mean-square error (RMSE) of this assumption in the circular post arrays peaked at 0.144. The RMSE in the triangular post array peaked at 0.136. Flow development occurred more rapidly in circular post arrays when compared to triangular post arrays. Additionally, the changes in critical bumping diameter (DCB) the DLD design metric used to calculate the size-based separation threshold were examined for 10 different row shift fractions (FRS). These errors correspond to a DCB that varies as much as 11.7% in the circular post arrays and 15.1% in the triangular post arrays.

scholarly journals Numerical Simulation of Separation of Circulating Tumor Cells from Blood Stream in Deterministic Lateral Displacement (DLD) Microfluidic Channel

2015 ◽  
Vol 32 (4) ◽  
pp. 463-471 ◽  
Author(s):  
F. Khodaee ◽  
S. Movahed ◽  
N. Fatouraee ◽  
F. Daneshmand
Keyword(s):  
Fluid Flow ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Microfluidic Device ◽  
Flow Condition ◽  
Lateral Displacement ◽  
Microfluidic Devices ◽  
Blood Stream ◽  
Deterministic Lateral Displacement ◽  
Effective Design

AbstractDeterministic Lateral Displacement (DLD) microfluidic devices provide a reliable label-free separation method for detection of circulating tumor cells (CTCs) in blood samples based on their biophysical properties. In this paper, we proposed an effective design of the DLD microfluidic device for the CTC separation in the blood stream. A typical DLD array is designed and numerical simulations are performed to separate the CTC and leukocyte (white blood cells) in different fluid flow conditions. Fluid-Solid Interaction method is used to investigate the behaviour of these deformable cells in fluid flow. In this study, the effects of critical parameters affecting cell separation in the DLD microfluidic devices (e.g.flow condition, cell deformability, and stress) have been investigated. The obtained results show that unlike leukocytes, the CTC’s motion is independent of the flow condition and is laterally displaced even in higher Reynolds number. Larger cells (CTCs) cannot intercept the low-velocity fluid near the wall of the posts; thus, they move faster and become separated from leukocytes. To reduce the cellular stress during separation process, which causes increase of cell viability and more effective design of microfluidic device, the results obtained here may be used as a significant design parameter for the DLD fabrication.

scholarly journals Efficient paradigm to enhance particle separation in deterministic lateral displacement arrays

2019 ◽  
Vol 1 (10) ◽  
Author(s):  
Amirali Ebadi ◽  
Mohammad Javad Farshchi Heydari ◽  
Reihaneh Toutouni ◽  
Bahareh Chaichypour ◽  
Morteza Fathipour ◽  
...  
Keyword(s):  
Lateral Displacement ◽  
Particle Separation ◽  
Deterministic Lateral Displacement
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