Drug-Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling

Small ◽  
2017 ◽  
Vol 13 (33) ◽  
pp. 1701276 ◽  
Author(s):  
Mónica P. A. Ferreira ◽  
Sanjeev Ranjan ◽  
Sini Kinnunen ◽  
Alexandra Correia ◽  
Virpi Talman ◽  
...  
Keyword(s):  
Multifunctional Nanoparticles ◽  
Hypertrophic Signaling ◽  
Endocardial Layer

scholarly journals Drug Delivery: Drug-Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling (Small 33/2017)

Small ◽  
2017 ◽  
Vol 13 (33) ◽  
Author(s):  
Mónica P. A. Ferreira ◽  
Sanjeev Ranjan ◽  
Sini Kinnunen ◽  
Alexandra Correia ◽  
Virpi Talman ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Multifunctional Nanoparticles ◽  
Hypertrophic Signaling ◽  
Endocardial Layer

The Role of the Initiator System in the Synthesis of Acidic Multifunctional Nanoparticles Designed for Molecular Imprinting of Proteins

2020 ◽  
Vol 65 (1) ◽  
pp. 28-41
Author(s):  
Marwa Aly Ahmed ◽  
Júlia Erdőssy ◽  
Viola Horváth
Keyword(s):  
Acrylic Acid ◽  
Binding Affinity ◽  
Molecular Imprinting ◽  
Low Temperatures ◽  
Ammonium Persulfate ◽  
Sodium Bisulfite ◽  
Multifunctional Nanoparticles ◽  
High Affinity ◽  
Initiator System

Multifunctional nanoparticles have been shown earlier to bind certain proteins with high affinity and the binding affinity could be enhanced by molecular imprinting of the target protein. In this work different initiator systems were used and compared during the synthesis of poly (N-isopropylacrylamide-co-acrylic acid-co-N-tert-butylacrylamide) nanoparticles with respect to their future applicability in molecular imprinting of lysozyme. The decomposition of ammonium persulfate initiator was initiated either thermally at 60 °C or by using redox activators, namely tetramethylethylenediamine or sodium bisulfite at low temperatures. Morphology differences in the resulting nanoparticles have been revealed using scanning electron microscopy and dynamic light scattering. During polymerization the conversion of each monomer was followed in time. Striking differences were demonstrated in the incorporation rate of acrylic acid between the tetramethylethylenediamine catalyzed initiation and the other systems. This led to a completely different nanoparticle microstructure the consequence of which was the distinctly lower lysozyme binding affinity. On the contrary, the use of sodium bisulfite activation resulted in similar nanoparticle structural homogeneity and protein binding affinity as the thermal initiation.

scholarly journals Ca2+ Release via IP3 Receptors Shapes the Cardiac Ca2+ Transient for Hypertrophic Signaling

2020 ◽  
Vol 119 (6) ◽  
pp. 1178-1192 ◽  
Author(s):  
Hilary Hunt ◽  
Agnė Tilūnaitė ◽  
Greg Bass ◽  
Christian Soeller ◽  
H. Llewelyn Roderick ◽  
...  
Keyword(s):  
Ip3 Receptors ◽  
Hypertrophic Signaling

One-step synthesis of multifunctional nanoparticles for CT/PA imaging guided breast cancer photothermal therapy

2021 ◽  
Vol 201 ◽  
pp. 111630
Author(s):  
Liwen Fu ◽  
Shuguang Yang ◽  
Shichao Jiang ◽  
Xiaojun Zhou ◽  
Zhou Sha ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photothermal Therapy ◽  
Multifunctional Nanoparticles ◽  
One Step

scholarly journals Automated Framework for the Inclusion of a His–Purkinje System in Cardiac Digital Twins of Ventricular Electrophysiology

2021 ◽  
Author(s):  
Karli Gillette ◽  
Matthias A. F. Gsell ◽  
Julien Bouyssier ◽  
Anton J. Prassl ◽  
Aurel Neic ◽  
...  
Keyword(s):  
Cardiac Electrophysiology ◽  
Ventricular Myocardium ◽  
Activation Patterns ◽  
Purkinje System ◽  
Digital Twins ◽  
Emergent Features ◽  
Ventricular Activation ◽  
Endocardial Layer ◽  
Right Ventricular Apical Pacing ◽  
Electrocardiogram Ecg

AbstractPersonalized models of cardiac electrophysiology (EP) that match clinical observation with high fidelity, referred to as cardiac digital twins (CDTs), show promise as a tool for tailoring cardiac precision therapies. Building CDTs of cardiac EP relies on the ability of models to replicate the ventricular activation sequence under a broad range of conditions. Of pivotal importance is the His–Purkinje system (HPS) within the ventricles. Workflows for the generation and incorporation of HPS models are needed for use in cardiac digital twinning pipelines that aim to minimize the misfit between model predictions and clinical data such as the 12 lead electrocardiogram (ECG). We thus develop an automated two stage approach for HPS personalization. A fascicular-based model is first introduced that modulates the endocardial Purkinje network. Only emergent features of sites of earliest activation within the ventricular myocardium and a fast-conducting sub-endocardial layer are accounted for. It is then replaced by a topologically realistic Purkinje-based representation of the HPS. Feasibility of the approach is demonstrated. Equivalence between both HPS model representations is investigated by comparing activation patterns and 12 lead ECGs under both sinus rhythm and right-ventricular apical pacing. Predominant ECG morphology is preserved by both HPS models under sinus conditions, but elucidates differences during pacing.

Creating BHb-imprinted magnetic nanoparticles with multiple binding sites

The Analyst ◽  
2017 ◽  
Vol 142 (2) ◽  
pp. 302-309 ◽  
Author(s):  
Yanxia Li ◽  
Yiting Chen ◽  
Lu Huang ◽  
BenYong Lou ◽  
Guonan Chen
Keyword(s):  
Magnetic Nanoparticles ◽  
Binding Sites ◽  
Multifunctional Nanoparticles ◽  
Multiple Binding Sites ◽  
Multiple Binding

A kind of protein imprinted over magnetic Fe3O4@Au multifunctional nanoparticles (NPs) with multiple binding sites was synthesized and investigated.

Photodynamic characterization and optimization using multifunctional nanoparticles for brain cancer treatment

2013 ◽  
Author(s):  
Kristen Herrmann ◽  
Yong-Eun Lee Koo ◽  
Daniel A. Orringer ◽  
Oren Sagher ◽  
Martin Philbert ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Brain Cancer ◽  
Multifunctional Nanoparticles
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