scholarly journals Nanomaterial Uptake: Fast Targeting and Cancer Cell Uptake of Luminescent Antibody-Nanozeolite Bioconjugates (Small 39/2016)

Small ◽  
2016 ◽  
Vol 12 (39) ◽  
pp. 5369-5369
Author(s):  
Riccardo Marega ◽  
Eko Adi Prasetyanto ◽  
Carine Michiels ◽  
Luisa De Cola ◽  
Davide Bonifazi
Keyword(s):  
Cancer Cell ◽  
Cell Uptake

scholarly journals Tumor acidity-induced charge-reversal liposomal doxorubicin with enhanced cancer cell uptake and anticancer activity

Giant ◽  
2021 ◽  
Vol 6 ◽  
pp. 100052 ◽  
Author(s):  
Jinpeng Yang ◽  
Zihe Yin ◽  
Yincheng Chang ◽  
Hua Wang ◽  
Jiang-Fei Xu ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cancer Cell ◽  
Liposomal Doxorubicin ◽  
Cell Uptake ◽  
Charge Reversal ◽  
Tumor Acidity ◽  
Induced Charge

Conjugation with α-linolenic acid improves cancer cell uptake and cytotoxicity of doxorubicin

2009 ◽  
Vol 19 (9) ◽  
pp. 2579-2584 ◽  
Author(s):  
Meng-lei Huan ◽  
Si-yuan Zhou ◽  
Zeng-hui Teng ◽  
Bang-le Zhang ◽  
Xin-you Liu ◽  
...  
Keyword(s):  
Linolenic Acid ◽  
Cancer Cell ◽  
Cell Uptake

Surface modification with cholesteryl acetyl carnitine, a novel cationic agent, elevates cancer cell uptake of the PEGylated liposomes

2021 ◽  
Vol 609 ◽  
pp. 121148
Author(s):  
Fahimeh Zahednezhad ◽  
Javid Shahbazi Mojarrad ◽  
Parvin Zakeri-Milani ◽  
Behzad Baradaran ◽  
Mohammad Mahmoudian ◽  
...  
Keyword(s):  
Surface Modification ◽  
Cancer Cell ◽  
Cell Uptake ◽  
Pegylated Liposomes

scholarly journals Control of targeting ligand display by pH-responsive polymers on gold nanoparticles mediates selective entry into cancer cells

Nanoscale ◽  
2017 ◽  
Vol 9 (31) ◽  
pp. 11137-11147 ◽  
Author(s):  
C. Brazzale ◽  
F. Mastrotto ◽  
P. Moody ◽  
P. D. Watson ◽  
A. Balasso ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cell Uptake ◽  
Ph Responsive ◽  
Responsive Polymers ◽  
Nanoparticle Surface ◽  
Site Selectivity ◽  
Ph Responsive Polymers

The pH-triggered display of targeting agent on nanoparticle surface controls cancer cell uptake. This enhances site-selectivity of nanosystems.

Synthesis and Evaluation of 198Au/PAMAM-MPEG-FA against Cancer Cells

2020 ◽  
Vol 20 (10) ◽  
pp. 1250-1265
Author(s):  
Reza Rezaei ◽  
Simin Janitabar Darzi ◽  
Mahnaz Yazdani
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Therapeutic Potential ◽  
Analytical Techniques ◽  
Cell Uptake ◽  
Breast Adenocarcinoma ◽  
Human Breast ◽  
Clinical Investigations ◽  
Anti Cancer

Background: There is a significant dearth of clinical biochemistry researches to evaluate the facility of exploitation of folate targeted radioactive gold-labeled anti-cancer drugs against various cancer cell lines. Objective: The aim of this paper was to develop a gold-based compound with an efficient therapeutic potential against breast cancer. To this end, the synthesis of the 198Au/PAMAM-MPEG-FA composite was considered here. Methods: The radioactive gold (198Au) nanoparticles were encapsulated into Folic acid (FA)-targeted Polyamidoamine dendrimer (PAMAM) modified with Maleimide-Polyethylene glycol Succinimidyl Carboxymethyl ester (MPEG). After that, anticancer assessments of the prepared 198Au/PAMAM-MPEG-FA hybrid mater against breast cancer were investigated. : Further studies were also devised to compare the anticancer capabilities of the 198Au/PAMAM-MPEG-FA composite with the synthesized P-MPEG, 197Au/P-MPEG, 197Au/P-MPEG-FA, 197Au/P-FA and 198Au/P-MPEG-FA conjugates. The prepared drugs were characterized by means of various analytical techniques. The radionuclidic purity of the 198Au/P-MPEG-FA solution was determined using High Purity Germanium (HPGe) spectroscopy and its stability in the presence of human serum was studied. The cell uptake and toxicity of the prepared drugs were evaluated in vitro, and some comparative studies of the toxicity of the drugs were conducted towards the MCF7 (Human breast cancer cell), 4T1 (Mice breast adenocarcinoma cell) and C2C12 (Mice muscle normal cell). Results: The results showed that cell uptake of 198Au/P-MPEG-FA nanoparticles is high in the 4T1 cell line and the order of uptake is as 4T1> MCF7> C2C12. Moreover, of the tested compounds, 198Au/P-MPEG-FA had the highest toxicity towards the cancerous 4T1 and MCF7 in all concentrations after 24, 48 and 72h (P < 0.001). Furthermore, the cytotoxicity of the drugs was concentration-dependent. Conclusion: On the basis of the present research, 198Au/P-MPEG-FA has been proposed as a good candidate for the induction of cell death in breast cancer, although further experimental and clinical investigations are required.

scholarly journals Enhanced cell uptake of fluorescent drug-loaded nanoparticles via an implantable photothermal fibrous patch for more effective cancer cell killing

2017 ◽  
Vol 5 (36) ◽  
pp. 7504-7511 ◽  
Author(s):  
Yangyang Li ◽  
Yike Fu ◽  
Zhaohui Ren ◽  
Xiang Li ◽  
Chuanbin Mao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Cell ◽  
Cell Killing ◽  
Cell Uptake ◽  
Effective Delivery

Great efforts have been devoted to effective delivery of therapeutics into cells for cancer therapy.

scholarly journals Gemcitabine and chlorotoxin conjugated iron oxide nanoparticles for glioblastoma therapy

2016 ◽  
Vol 4 (1) ◽  
pp. 32-36 ◽  
Author(s):  
Qingxin Mu ◽  
Guanyou Lin ◽  
Victoria K. Patton ◽  
Kui Wang ◽  
Oliver W. Press ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Blood Brain Barrier ◽  
Iron Oxide Nanoparticles ◽  
Cancer Cell ◽  
Half Life ◽  
Cell Uptake ◽  
Brain Barrier ◽  
Oxide Nanoparticles ◽  
Blood Brain ◽  
Barrier Penetration

Nanoparticles bearing gemcitabine and chlorotoxin show efficient cancer cell uptake and killing, extended blood half-life, and blood–brain barrier penetration.

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