scholarly journals Control of targeting ligand display by pH-responsive polymers on gold nanoparticles mediates selective entry into cancer cells

Nanoscale ◽  
2017 ◽  
Vol 9 (31) ◽  
pp. 11137-11147 ◽  
Author(s):  
C. Brazzale ◽  
F. Mastrotto ◽  
P. Moody ◽  
P. D. Watson ◽  
A. Balasso ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cell Uptake ◽  
Ph Responsive ◽  
Responsive Polymers ◽  
Nanoparticle Surface ◽  
Site Selectivity ◽  
Ph Responsive Polymers

The pH-triggered display of targeting agent on nanoparticle surface controls cancer cell uptake. This enhances site-selectivity of nanosystems.

scholarly journals Gold nanoparticles conjugated with anti-CD133 monoclonal antibody and 5-fluorouracil chemotherapeutic agent as nanocarriers for cancer cell targeting

RSC Advances ◽  
2021 ◽  
Vol 11 (26) ◽  
pp. 16131-16141
Author(s):  
Manali Haniti Mohd-Zahid ◽  
Siti Nadiah Zulkifli ◽  
Che Azurahanim Che Abdullah ◽  
JitKang Lim ◽  
Sharida Fakurazi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Monoclonal Antibody ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Chemotherapeutic Agent ◽  
Cell Targeting ◽  
Specific Targeting ◽  
Colorectal Cancer Cells ◽  
Cancer Cell Targeting

5-FU-PEGylated AuNPs-CD133 is designed to improve specific targeting of 5-FU against colorectal cancer cells which abundantly express CD133.

A General Method for the Synthesis and Isolation of Well-Defined Core Cross-Linked Multistar Assemblies: A Route toward Enhanced pH-Responsive Polymers

2009 ◽  
Vol 42 (13) ◽  
pp. 4622-4631 ◽  
Author(s):  
Jing Fung Tan ◽  
Anton Blencowe ◽  
Tor Kit Goh ◽  
Irving Ted M. Dela Cruz ◽  
Greg G. Qiao
Keyword(s):  
Ph Responsive ◽  
Responsive Polymers ◽  
Ph Responsive Polymers ◽  
General Method

The Effects of Substituent Grafting on the Interaction of pH-Responsive Polymers with Phospholipid Monolayers

Langmuir ◽  
2011 ◽  
Vol 27 (13) ◽  
pp. 8530-8539 ◽  
Author(s):  
Shengwen Zhang ◽  
Andrew Nelson ◽  
Zachary Coldrick ◽  
Rongjun Chen
Keyword(s):  
Ph Responsive ◽  
Responsive Polymers ◽  
Phospholipid Monolayers ◽  
Ph Responsive Polymers

Graft modification of starch nanoparticles with pH‐responsive polymers via nitroxide‐mediated polymerization

2020 ◽  
Vol 58 (16) ◽  
pp. 2211-2220
Author(s):  
Jaime C. Cazotti ◽  
Alexander T. Fritz ◽  
Omar Garcia‐Valdez ◽  
Niels M. B. Smeets ◽  
Marc A. Dubé ◽  
...  
Keyword(s):  
Ph Responsive ◽  
Responsive Polymers ◽  
Graft Modification ◽  
Starch Nanoparticles ◽  
Ph Responsive Polymers ◽  
Nitroxide Mediated Polymerization

pH-Responsive Polymers: Properties, Synthesis, and Applications

2019 ◽  
pp. 45-86
Author(s):  
Luis García-Fernández ◽  
Ana Mora-Boza ◽  
Felisa Reyes-Ortega
Keyword(s):  
Ph Responsive ◽  
Responsive Polymers ◽  
Ph Responsive Polymers

scholarly journals Ultrasensitive (Co)polymers Based on Poly(methacrylamide) Structure with Fining-Tunable pH Responsive Value

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1870 ◽  
Author(s):  
Haiming Fan ◽  
Po Li ◽  
Wei Li ◽  
Hui Li ◽  
Xiaonan Huang
Keyword(s):  
Hydrophobic Effect ◽  
Proton Nuclear Magnetic Resonance ◽  
Resonance Spectroscopy ◽  
Ph Responsive ◽  
Responsive Polymers ◽  
Novel Approach ◽  
Pka Value ◽  
Methacrylate Monomers ◽  
Amine Groups ◽  
Ph Responsive Polymers

Novel pH responsive copolymers with tertiary amine groups were prepared by free radical polymerization with 2-(dialkylamino)ethyl methacrylate monomers. These polymers were pH sensitive with the ability to be responsively fine-tuned in aqueous solution, which was proven through titration, transmittance measurements, and proton nuclear magnetic resonance spectroscopy. The polymers were soluble in water at low pH values, induced by electrostatic repulsion between amine groups, and aggregated above their pKa value due to the hydrophobic effect of the alkyls. The pH responsive values were precisely tuned from 7.4 to 4.8 by increasing the hydrophobic monomer ratio. Our work provides a novel approach for the development of ultrasensitive pH-responsive polymers for application in biomedical materials.

Synthesis of Gold Nanoparticles Coated with pH-Responsive Polymers and Evaluation of the Cellular Uptake

2012 ◽  
Vol 1416 ◽  
Author(s):  
Takeo Ito ◽  
Eriko Kusaka ◽  
Yu Isobe ◽  
Sei-ichi Nishimoto
Keyword(s):  
Cellular Uptake ◽  
Gold Nanorods ◽  
Near Infrared ◽  
A549 Cells ◽  
Endocytic Pathway ◽  
Human Lung Cancer ◽  
Ph Responsive ◽  
Absorption Bands ◽  
Responsive Polymers ◽  
Ph Responsive Polymers

ABSTRACTGold nanorods (AuNRs) show surface plasmon absorption bands in the near-infrared region. This characteristic property has stimulated utilization of gold nanorods as novel nanoprobes for noninvasive bioimaging, such as photoacoustic tomography. Herein, we discuss the synthesis of a series of gold nanorods coated with pH-responsive polymers to investigate the effect of the surface structure and zeta potential of nanoparticles on cellular uptake via a surface charge-mediated endocytic pathway. The surface of the gold nanorods was modified with polyethylene glycol (PEG@AuNR) and tertiary amine derivatives, specifically, diethylaminoethyl ester (1@AuNRs), its amide analog (2@AuNRs), and dimethylaminoethyl ester (3@AuNRs). It was found that the pH-sensitivity of1@AuNRs was relatively high and the surface was positively charged at lower pH. In contrast, the tertiary amino group of1@AuNRs was deprotonated to form an electrostatically neutral surface at higher pH. The pH-responsive gold nanorods were incubated with A549 cells (human lung cancer cells) to quantify the amount of cellular uptake using inductively coupled plasma mass spectrometry. The results indicate that1@AuNRs can be taken up efficiently in the cells, and thereafter, slowly flow out of the cells. Interestingly, only small amounts of the amide analog (2@AuNRs) were taken into the cells, suggesting minor structural changes may affect the interaction between the cell surface and AuNRs. This study highlights a potential application of pH-sensitive nanorods as a probe for bioimaging the acidic environment of tumors.

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