Engineered Redox-Responsive PEG Detachment Mechanism in PEGylated Nano-Graphene Oxide for Intracellular Drug Delivery

Small ◽  
2012 ◽  
Vol 8 (5) ◽  
pp. 760-769 ◽  
Author(s):  
Huiyun Wen ◽  
Chunyan Dong ◽  
Haiqing Dong ◽  
Aijun Shen ◽  
Wenjuan Xia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Intracellular Drug Delivery ◽  
Redox Responsive ◽  
Nano Graphene

Functionalized Nano-graphene Oxide as Multi-modal Clinic for Effective Drug Delivery

2017 ◽  
Vol 10 (4) ◽  
pp. 3768-3771
Author(s):  
Soumitra Satapathi ◽  
Rutusmita Mishra ◽  
Manisha Chatterjee ◽  
Partha Roy ◽  
Somesh Mohapatra
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Cell ◽  
High Surface ◽  
High Surface Area ◽  
Cancer Cell Line ◽  
Xrd Analysis ◽  
Graphene Derivatives ◽  
Nano Graphene

Nano-materials based drug delivery modalities to specific organs and tissues has become one of the critical endeavors in pharmaceutical research. Recently, two-dimensional graphene has elicited considerable research interest because of its potential application in drug delivery systems. Here we report, the drug delivery applications of PEGylated nano-graphene oxide (nGO-PEG), complexed with a multiphoton active and anti-cancerous diarylheptanoid drug curcumin. Specifically, graphene-derivatives were used as nanovectors for the delivery of the hydrophobic anticancer drug curcumin due to its high surface area and easy surface functionalization. nGO was synthesized by modified Hummer’s method and confirmed by XRD analysis. The formation of nGO, nGO-PEG and nGO-PEG-Curcumin complex were monitored through UV-vis, IR spectroscopy. MTT assay and AO/EB staining found that nGO-PEG-Curcumin complex afforded highly potent cancer cell killing in vitro with a human breast cancer cell line MCF7.

Doxorubicin Loaded Nanoparticle Consisting of Chitosan and Mannose Modified Graphene Oxide for Intracellular Drug Delivery and Anti-tumor Activity

2020 ◽  
Vol 13 (5) ◽  
pp. 5155-5164
Author(s):  
Meena K. S. ◽  
Sonia K ◽  
Alamelu Bai S
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Release ◽  
Cancer Drug ◽  
Hemolysis Assay ◽  
Functionalized Graphene Oxide ◽  
Intracellular Drug Delivery ◽  
Modified Graphene Oxide

In order to develop the efficiency and the specificity of anticancer drug delivery, we have designed an innovative nanocarrier. The nanocarrier system comprises of a multifunctional graphene oxide nanoparticle-based drug delivery system (GO-CS-M-DOX) as a novel platform for intracellular drug delivery of doxorubicin (DOX). Firstly, graphene oxide (GO) was synthesized by hummer’s method whose surface was functionalized by chitosan (CS) in order to obtain a more precise drug delivery, the system was then decorated with mannose (M). Further conjugation of an anti-cancer drug doxorubicin to the nanocarrier system resulted in GO-CS-M-DOX drug delivery system. The resultant conjugate was characterized for its physio-chemical properties and its biocompatibility was evaluated via hemolysis assay. The drug entrapment efficiency is as high as 90% and in vitro release studies of DOX under pH 5.3 is significantly higher than that under pH 7.4. The anticancer activity of the synthesized drug delivery system was studied by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay against MCF-7 cell line. These results stated that the pH dependent multifunctional doxorubicin- chitosan functionalized graphene oxide based nanocarrier system, could lead to a promising and potential platform for intracellular delivery and cytotoxicity activity for variety of anticancer drugs.   

Redox responsive liposomal nanohybrid cerasomes for intracellular drug delivery

2016 ◽  
Vol 148 ◽  
pp. 518-525 ◽  
Author(s):  
Gaoxin Zhou ◽  
Lushen Li ◽  
Jing Xing ◽  
Shivakumar Jalde ◽  
Yan Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Intracellular Drug Delivery ◽  
Redox Responsive

A multifunctional PEG–PLL drug conjugate forming redox-responsive nanoparticles for intracellular drug delivery

2015 ◽  
Vol 3 (38) ◽  
pp. 7594-7603 ◽  
Author(s):  
Zhuxian Zhou ◽  
Jianbin Tang ◽  
Qihang Sun ◽  
William J. Murdoch ◽  
Youqing Shen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Tumor Targeting ◽  
High Stability ◽  
Cancer Targeting ◽  
Drug Conjugate ◽  
Intracellular Drug Delivery ◽  
Redox Responsive ◽  
Triggered Drug Release

Tumor-targeting camptothecin (CPT)-conjugated nanoparticles with high stability and GSH-triggered drug release were developed for cancer targeting drug delivery.

Reductive response and RGD targeting nano-graphene oxide drug delivery system

2019 ◽  
Vol 53 ◽  
pp. 101202 ◽  
Author(s):  
Mei Wei ◽  
Taicheng Lu ◽  
Zhenzhen Nong ◽  
Guo Li ◽  
Xin Pan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nano Graphene

Hepatotoxicity induced by intravenous administration of PEGylated nano-graphene oxide in albino mice

2021 ◽  
Vol 11 (10) ◽  
pp. 1668-1673
Author(s):  
Abir Abdullah Alamro ◽  
Samina Hyder Haq ◽  
Amani Alghamdi ◽  
Nojood Altawaijri ◽  
Amjad Saeed Alali ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Liver Function ◽  
Intravenous Administration ◽  
Liver Homogenate ◽  
Inflammatory Cells ◽  
Liver Function Tests ◽  
Response To Stress ◽  
Nano Graphene ◽  
Mice Liver

Graphene oxide (GO) has been intensely investigated in recent years due to its biocompatibility and its role in drug delivery. Its conjugation with polyethylene glycol (PEG) further improves its solubility in physiological solutions, which is important for enhancing efficacy of drug delivery. The present study aimed to assess the hepatotoxicity of PEG-nGO in mature mice. Liver function tests such as Alanine transferase (ALT), Alkaline phosphatase (ALP) were performed in the liver homogenate of the control and treated groups after intravenous administration of a single dose (5 mg/kg) of PEG-nGO through the tail vein. Total Glycogen content and lactate dehydrogenase (LDH) activity was measured. For histology studies, liver slices were fixed in 10% formalin and stained with H&E and photographed. The liver function test indicated a significant increase in ALT and ALP activity following 1 to 2 h of treatment with PEG-nGO, which recovers to normal levels at 4 h. Total glycogen contents were mobilized from the liver in the first hour in response to stress, which again regain normality after 4 h. The LDH assay showed maximum necrosis and apoptosis of hepatocytes at 1 h. Histology studies further indicated that infiltration of inflammatory cells and vacuolization of cytoplasm occurred mostly at 1 h. PEG-nGO treatments caused maximum damage and toxicity to the liver during the first 2 h. Following this, the liver tissues recover substantially which indicated that the low dose toxicity of PEG-nGO to the liver was transient and reversible.

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