scholarly journals Controlling Differentiation of Neural Stem Cells Using Extracellular Matrix Protein Patterns

Small ◽  
2010 ◽  
Vol 6 (22) ◽  
pp. 2509-2513 ◽  
Author(s):  
Aniruddh Solanki ◽  
Shreyas Shah ◽  
Kevin A. Memoli ◽  
Sung Young Park ◽  
Seunghun Hong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Neural Stem Cells ◽  
Matrix Protein ◽  
Extracellular Matrix Protein ◽  
Protein Patterns

Stem cell differentiation: Controlling Differentiation of Neural Stem Cells Using Extracellular Matrix Protein Patterns (Small 22/2010)

Small ◽  
2010 ◽  
Vol 6 (22) ◽  
pp. 2508-2508
Author(s):  
Aniruddh Solanki ◽  
Shreyas Shah ◽  
Kevin A. Memoli ◽  
Sung Young Park ◽  
Seunghun Hong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Neural Stem Cells ◽  
Matrix Protein ◽  
Stem Cell Differentiation ◽  
Extracellular Matrix Protein ◽  
Protein Patterns

scholarly journals CD93 negatively regulates astrogenesis in response to MMRN2 through the transcriptional repressor ZFP503 in the developing brain

2020 ◽  
Vol 117 (17) ◽  
pp. 9413-9422
Author(s):  
Qingli Liang ◽  
Libo Su ◽  
Dongming Zhang ◽  
Jianwei Jiao
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Matrix Protein ◽  
Transcriptional Repressor ◽  
Negative Regulator ◽  
Extracellular Matrix Protein ◽  
Embryonic Period ◽  
Mouse Cerebral Cortex ◽  
Negative Role ◽  
Insight Into

Astrogenesis is repressed in the early embryonic period and occurs in the late embryonic period. A variety of external and internal signals contribute to the sequential differentiation of neural stem cells. Here, we discovered that immune-related CD93 plays a critical negative role in the regulation of astrogenesis in the mouse cerebral cortex. We show that CD93 expression is detected in neural stem cells and neurons but not in astrocytes and declines as differentiation proceeds. Cd93 knockout increases astrogenesis at the expense of neuron production during the late embryonic period. CD93 responds to the extracellular matrix protein Multimerin 2 (MMRN2) to trigger the repression of astrogenesis. Mechanistically, CD93 delivers signals to β-Catenin through a series of phosphorylation cascades, and then β-Catenin transduces these signals to the nucleus to activate Zfp503 transcription. The transcriptional repressor ZFP503 inhibits the transcription of glial fibrillary acidic protein (Gfap) by binding to the Gfap promoter with the assistance of Grg5. Furthermore, Cd93 knockout mice exhibit autism-like behaviors. Taken together, our results reveal that CD93 is a negative regulator of the onset of astrogenesis and provide insight into therapy for psychiatric disorders.

Tissue Engineering: Stable Extracellular Matrix Protein Patterns Guide the Orientation of Osteoblast-like Cells (Adv. Funct. Mater. 21/2011)

2011 ◽  
Vol 21 (21) ◽  
pp. 4199-4199
Author(s):  
Jian-Tao Zhang ◽  
Juequan Nie ◽  
Mike Mühlstädt ◽  
Hilary Gallagher ◽  
Oliver Pullig ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Matrix Protein ◽  
Extracellular Matrix Protein ◽  
Protein Patterns

Stable Extracellular Matrix Protein Patterns Guide the Orientation of Osteoblast-like Cells

2011 ◽  
Vol 21 (21) ◽  
pp. 4079-4087 ◽  
Author(s):  
Jian-Tao Zhang ◽  
Juequan Nie ◽  
Mike Mühlstädt ◽  
Hilary Gallagher ◽  
Oliver Pullig ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Matrix Protein ◽  
Extracellular Matrix Protein ◽  
Protein Patterns

Differentiation of Rat Mesenchymal Stem Cells toward Osteogenic Lineage on Extracellular Matrix Protein Gradients

2019 ◽  
Vol 8 (17) ◽  
pp. 1900595 ◽  
Author(s):  
Soraya Rasi Ghaemi ◽  
Bahman Delalat ◽  
Alex Cavallaro ◽  
Agnieszka Mierczynska‐Vasilev ◽  
Krasimir Vasilev ◽  
...  
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Mesenchymal Stem Cells ◽  
Matrix Protein ◽  
Extracellular Matrix Protein ◽  
Osteogenic Lineage ◽  
Protein Gradients
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