P(NMe 2 ) 3 ‐Mediated Reductive (1+4) Annulation Reaction of α ‐Keto Esters with Nitroalkenes: A Facile Synthesis of Polysubstituted Isoxazoline N ‐Oxides

2021 ◽  
Vol 6 (17) ◽  
pp. 4400-4403
Author(s):  
Yiyi Liu ◽  
Kanghui Lu ◽  
Tao Wan ◽  
Jiaqiang Wei ◽  
Junjie Wu ◽  
...  
Keyword(s):  
Facile Synthesis ◽  
Keto Esters

Synthesis of β- and β,β-substituted Morita–Baylis–Hillman adducts using a two-step protocol

2012 ◽  
Vol 90 (5) ◽  
pp. 450-463 ◽  
Author(s):  
David I. Magee ◽  
Same Ratshonka ◽  
Jessica McConaghy ◽  
Maggie Hood
Keyword(s):  
Knoevenagel Condensation ◽  
Condensation Reaction ◽  
Facile Synthesis ◽  
Aliphatic Aldehydes ◽  
Tert Butyl ◽  
Keto Esters ◽  
Knoevenagel Condensation Reaction

The synthesis of a large number of β- and β,β-substituted keto esters was successful by the use of the Knoevenagel condensation reaction. The stereoselectivity of these reactions was improved by alteration of various substituent groups. Although there were few examples of complete Z selectivity, the use of tert-butyl acetoacetate with either aromatic or aliphatic aldehydes afforded Z selectivity. The selective reductions of these substituted keto esters was successfully achieved by using a combination of NaBH4 and CeCl3·7H2O or Yb(OTf)3, which allowed a facile synthesis of a large number of stereochemically pure substituted Morita–Baylis–Hillman adducts, including β,β-substituted adducts.

Facile Synthesis of Aryl α-Keto Esters via the Reaction of Aryl Diazoacetate with H2O and DEAD.

ChemInform ◽  
2007 ◽  
Vol 38 (3) ◽  
Author(s):  
Zhenqiu Guo ◽  
Haoxi Huang ◽  
Qingquan Fu ◽  
Wenhao Hu
Keyword(s):  
Facile Synthesis ◽  
Keto Esters

Facile Synthesis of α-Keto Esters via A Free Radical Acylation Approach

Synlett ◽  
1997 ◽  
Vol 1997 (Sup. I) ◽  
pp. 475-476 ◽  
Author(s):  
Sunggak Kim ◽  
Joo-Yong Yoon ◽  
Ill Lee
Keyword(s):  
Free Radical ◽  
Facile Synthesis ◽  
Keto Esters

ChemInform Abstract: Direct, Facile Synthesis of N-Acyl-α-amino Amides from α-Keto Esters and Ammonia.

ChemInform ◽  
2009 ◽  
Vol 40 (4) ◽  
Author(s):  
Rukundo Ntaganda ◽  
Tamara Milovic ◽  
Jorge Tiburcio ◽  
Avinash N. Thadani
Keyword(s):  
Facile Synthesis ◽  
Keto Esters ◽  
Amino Amides

ChemInform Abstract: Facile Synthesis of N-Protected γ- and δ-Amino-β-keto-esters.

ChemInform ◽  
2010 ◽  
Vol 30 (49) ◽  
pp. no-no
Author(s):  
Baoqing Li ◽  
Richard W. Franck
Keyword(s):  
Facile Synthesis ◽  
Keto Esters
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