Structural Related Effects of Natural Steroid Molecules on Cholesterol Crystallization in Model Bile and Ethanol

2018 ◽  
Vol 3 (13) ◽  
pp. 3712-3717
Author(s):  
Jie Jing ◽  
Tongxin Wei ◽  
Wenqiang Su ◽  
Yonghai Liu ◽  
Weiwei Yao ◽  
...  
Keyword(s):  
Model Bile

scholarly journals Use of 1H-NMR to determine the distribution of lecithin between the micellar and vesicular phases in model bile.

1990 ◽  
Vol 31 (7) ◽  
pp. 1315-1321
Author(s):  
AK Groen ◽  
BG Goldhoorn ◽  
PH Egbers ◽  
RA Chamuleau ◽  
GN Tytgat ◽  
...  
Keyword(s):  
1H Nmr ◽  
Model Bile

scholarly journals Effect of cholesterol nucleation-promoting activity on cholesterol solubilization in model bile.

1989 ◽  
Vol 30 (1) ◽  
pp. 51-58
Author(s):  
A K Groen ◽  
R Ottenhoff ◽  
P L Jansen ◽  
J van Marle ◽  
G N Tytgat
Keyword(s):  
Cholesterol Solubilization ◽  
Model Bile

Studies of model bile solutions using surfactant ion electrodes

1983 ◽  
Vol 87 (24) ◽  
pp. 5015-5019 ◽  
Author(s):  
Kyoo Ryu ◽  
James M. Lowery ◽  
D. Fennell Evans ◽  
E. L. Cussler
Keyword(s):  
Model Bile

The Nucleation of Cholesterol Monohydrate Crystals in Model Bile Solutions

Gallstones ◽  
1979 ◽  
pp. 169-181 ◽  
Author(s):  
E. W. Toor ◽  
D. F. Evans ◽  
E. L. Cussler
Keyword(s):  
Cholesterol Monohydrate ◽  
Model Bile

Influence of cholesterol crystallization effector proteins on vesicle fusion in supersaturated model bile

1999 ◽  
Vol 14 (7) ◽  
pp. 669-674 ◽  
Author(s):  
Yoshihiro Hattori ◽  
Susumu Tazuma ◽  
Gunji Yamashita ◽  
Goro Kajiyama
Keyword(s):  
Vesicle Fusion ◽  
Effector Proteins ◽  
Model Bile

scholarly journals Lecithin hydrophobicity modulates the process of cholesterol crystal nucleation and growth in supersaturated model bile systems

1996 ◽  
Vol 318 (1) ◽  
pp. 139-144 ◽  
Author(s):  
Hidenori OCHI ◽  
Susumu TAZUMA ◽  
Goro KAJIYAMA
Keyword(s):  
Acyl Chain ◽  
Egg Yolk ◽  
Nucleation And Growth ◽  
Particle Size Analysis ◽  
Crystal Nucleation ◽  
Size Analysis ◽  
Cholesterol Crystal ◽  
Egg Yolk Phosphatidylcholine ◽  
Bile Cholesterol ◽  
Model Bile

The present study was performed to determine whether the degree of lecithin hydrophobicity regulates bile metastability and, therefore, affects the process of cholesterol crystallization. Supersaturated model bile (MB) solutions were prepared with an identical composition on a molar basis (taurocholate/lecithin/cholesterol, 73:19.5:7.5; total lipid concentration 9 g/dl) except for the lecithin species; egg yolk phosphatidylcholine, soybean phosphatidylcholine, 1-palmitoyl-2-linoleoyl-sn-phosphatidylcholine, dilinoleoyl phosphatidylcholine and dipalmitoyl phosphatidylcholine. Each MB solution was incubated and sequentially examined. Video-enhanced contrast microscopy demonstrated that the rate of vesicular aggregation and fusion correlated with the degree of lecithin hydrophobicity, and that the rate of cholesterol crystal nucleation correlated with the degree of lecithin hydrophilicity. In MBs containing less hydrophobic lecithin, needle-like crystals developed and transformed into mature plate-like crystals, whereas classical plate-like crystals were consistently observed in MBs composed of hydrophobic lecithin. Laser-diffraction particle size analysis demonstrated that the increase in lecithin hydrophobicity enlarged the vesicle dimension, enhancing its cholesterol-holding capacity. Correlation between vesicular cholesterol packing density and lecithin hydrophobicity suggests that the process of bile cholesterol nucleation and growth is regulated, in part, by acyl chain unsaturation in lecithin. Since the composition of biliary lecithins is responsive to dietary manipulations, this study provides new insights into the prevention of cholesterol gallstones.

Cholesterol crystallization from a dilute bile salt-rich model bile

1994 ◽  
Vol 144 (1-2) ◽  
pp. 79-86 ◽  
Author(s):  
Fred M. Konikoff ◽  
Martin C. Carey
Keyword(s):  
Bile Salt ◽  
Model Bile
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