Influence of neutral salts on acid-base equilibria: V. The first and second dissociation constant of succinic acid, tartaric acid and adipinic acid, and the influence of neutral salts on the pH of a mixture of the acid and its acid salt, and the acid salt

2010 ◽  
Vol 47 (10) ◽  
pp. 861-872
Author(s):  
I. M. Kolthoff ◽  
Wouter Bosch
Keyword(s):  
Succinic Acid ◽  
Dissociation Constant ◽  
Tartaric Acid ◽  
Acid Salt ◽  
Acid Base ◽  
Second Dissociation Constant

Total weak acid concentration and effective dissociation constant of nonvolatile buffers in human plasma

2001 ◽  
Vol 91 (3) ◽  
pp. 1364-1371 ◽  
Author(s):  
Peter D. Constable
Keyword(s):  
Dissociation Constant ◽  
Human Plasma ◽  
Total Concentration ◽  
Weak Acid ◽  
Strong Ion Difference ◽  
Acid Base ◽  
Horse Plasma ◽  
Using Data ◽  
Species Specific

The strong ion approach provides a quantitative physicochemical method for describing the mechanism for an acid-base disturbance. The approach requires species-specific values for the total concentration of plasma nonvolatile buffers (Atot) and the effective dissociation constant for plasma nonvolatile buffers ( K a), but these values have not been determined for human plasma. Accordingly, the purpose of this study was to calculate accurate Atot and K a values using data obtained from in vitro strong ion titration and CO2tonometry. The calculated values for Atot (24.1 mmol/l) and K a (1.05 × 10−7) were significantly ( P < 0.05) different from the experimentally determined values for horse plasma and differed from the empirically assumed values for human plasma (Atot = 19.0 meq/l and K a = 3.0 × 10−7). The derivatives of pH with respect to the three independent variables [strong ion difference (SID), Pco 2, and Atot] of the strong ion approach were calculated as follows: [Formula: see text] [Formula: see text], [Formula: see text]where S is solubility of CO2 in plasma. The derivatives provide a useful method for calculating the effect of independent changes in SID+, Pco 2, and Atot on plasma pH. The calculated values for Atot and K a should facilitate application of the strong ion approach to acid-base disturbances in humans.

Second dissociation constant of 3-(N-morpholino)-2-hydroxypropanesulfonic acid and pH of its buffer solutions

1993 ◽  
Vol 65 (8) ◽  
pp. 1084-1087 ◽  
Author(s):  
Y. C. Wu ◽  
P. A. Berezansky ◽  
Daming. Feng ◽  
W. F. Koch
Keyword(s):  
Dissociation Constant ◽  
Buffer Solutions ◽  
Second Dissociation Constant

Simultaneous Gas Chromatographic Determination of Carboxylic Acids in Soft Drinks and Jams

1985 ◽  
Vol 68 (5) ◽  
pp. 902-905
Author(s):  
Taizo Tsuda ◽  
Hiroshi Nakanishi ◽  
Takashi Morita ◽  
Junko Takebayashi
Keyword(s):  
Benzoic Acid ◽  
Succinic Acid ◽  
Tartaric Acid ◽  
Carboxylic Acids ◽  
Fumaric Acid ◽  
Malic Acid ◽  
Sorbic Acid ◽  
Chromatographic Determination ◽  
Dehydroacetic Acid

Abstract A method was developed for simultaneous gas chromatographic determination of sorbic acid, dehydroacetic acid, and benzoic acid used as preservatives, and succinic acid, fumaric acid, malic acid, and tartaric acid used as acidulants in soft drinks and jams. A sample was dissolved in NH4OH-NH4CI pH 9 buffer solution, and an aliquot of the solution was passed through a QAE-Sephadex A 25 column. The column was washed with water, and the carboxylic acids were eluted with 0.1N HC1. Sorbic acid, dehydroacetic acid, and benzoic acid were extracted with ethyl ether-petroleum ether (1 + 1), and determined on a 5% DEGS + 1% H3PO4 column. Succinic acid, fumaric acid, malic acid, and tartaric acid in the lower layer were derivatized with N,0- bis(trimethylsilyl)acetamide and trimethylchlorosilane, and determined on a 3% SE-30 column. Recoveries from soft drink and jam samples fortified with 0.1% each of 7 carboxylic acids ranged from 92.4 to 102.6% for preservatives, and from 88.1 to 103.2% for acidulants.

The determination of the second dissociation constant of sulfuric acid

1994 ◽  
Vol 23 (1) ◽  
pp. 75-80 ◽  
Author(s):  
P. Luts ◽  
J. Vanhees ◽  
J. Yperman ◽  
J. Mullens ◽  
L. C. Van Poucke
Keyword(s):  
Sulfuric Acid ◽  
Dissociation Constant ◽  
Second Dissociation Constant
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