scholarly journals Voriconazole treatment of pulmonary mycosis caused by Chrysosporium zonatum after treatment for pulmonary tuberculosis

2021 ◽  
Vol 9 (6) ◽  
Author(s):  
Takuya Matsuzaki ◽  
Hajime Kasai ◽  
Hideki Ikeda ◽  
Yuki Tajiri ◽  
Kenichi Suzuki ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Pulmonary Mycosis

scholarly journals Identifikasi Aspergillus fumigatus pada Sputum Pasien Suspek TB Paru

2019 ◽  
Vol 7 (1) ◽  
pp. 96-103
Author(s):  
Angriani Fusvita ◽  
Firdayanti Firdayanti ◽  
Sri Yosin Vinola
Keyword(s):  
Infectious Disease ◽  
Pulmonary Tuberculosis ◽  
Aspergillus Fumigatus ◽  
Sampling Technique ◽  
Potato Dextrose Agar ◽  
Culture Result ◽  
Tuberculosis Patients ◽  
Pulmonary Mycosis ◽  
Town Hospital ◽  
Microscopic Slide

Tuberculosis (TB) is a contagious infectious disease caused by the Mycobacterium tuberculosis, which can attack various organs especially the lungs. In some cases, there is a misdiagnosis between pulmonary tuberculosis and pulmonary mycosis (lung fungus). One of the species of fungus that often causing infection in the lungs is Aspergillus fumigatus.This study aims to identify Aspergillus fumigatus in sputum patients suspected of pulmonary tuberculosis patients at General Hospital in Baubau City. The types of research is descriptive with accidental sampling technique. Research was carried out by examining the BTA status of patients using the GeneXpert device and the patients sputum were isolated into Potato Dextrose Agar (PDA) medium then examined in macroscopic and microscopic (slide culture). Result of the study of 27 samples sputum patients suspected of pulmonary tuberculosis in Baubau Town Hospital obtained patients who infected Aspergillus fumigatus fungus amounted to 3 people with 2 including identified fungi with positive BTA status. Conclusion patients infected with Aspergillus fumigatus amounted to 3 people (7.4%) and 2 people (3.4%) identified fungi with positive pulmonary tuberculosis

scholarly journals Profiling of Pulmonary Fungal Pathogens and the Prevalence of Pulmonary Tuberculosis Fungal Co-Infection in Presumptive Tuberculosis Patients Referred to Saint Peter’s Tuberculosis Referral Hospital, Addis Ababa, Ethiopia

2021 ◽  
Author(s):  
Adane Bitew ◽  
Solomon Bati
Keyword(s):  
Pulmonary Tuberculosis ◽  
Fungal Pathogens ◽  
Addis Ababa ◽  
Age Groups ◽  
Brain Heart Infusion ◽  
Cross Sectional Study ◽  
Isolation Rate ◽  
Cross Sectional ◽  
Pulmonary Mycosis ◽  
High Prevalence

Abstract Background: The burden of pulmonary mycosis is increasing and often misdiagnosed as pulmonary tuberculosis in developing countries where the prevalence of pulmonary tuberculosis is high. Objective: To determine the prevalence of pulmonary mycosis and pulmonary tuberculosis fungal co-infections. Methods: A hospital-based, cross-sectional study was conducted between October 2019 and May 2019. Sputum was collected from 636 study subjects. Part of the sputum was inoculated onto Brain Heart Infusion agar and fungi were identified following standard microbiological procedures. The remaining part of the sample was used for the investigation of pulmonary tuberculosis by GeneXpert.Results: Among 636 sputum samples, 75.9% (483), 25.6% (163), and 20% (127) were positive for fungal pathogens, pulmonary tuberculosis, and pulmonary tuberculosis fungal co-infection, respectively. Of 690 fungal isolates, 81.4% were yeasts compromising of 46.3% Candida albicans 52.7% Non-albicans Candida species, and 1.0% Cryptococcus neoformans. The remaining 128 (18.6%) isolates were molds, where Aspergillus species (79; 61.7%), Penicillium species (16; 12.5%), Scedosporium apiospermum (13; 10.2%), and Fusarium species (10;7.8%) being the major isolates. The isolation rate of fungi was higher in males (51.6%) than in females (48.4%). There was no statistically significant association between the prevalence of pulmonary fungal pathogens and sex (P=0.239). Patients in the age group of 35-44 and above were slightly more affected than younger age groups. The association of fungal pathogens and age was not statistically significant (P=0.50). Conclusions: Our study revealed a high prevalence of pulmonary fungal pathogens (75.4%) and pulmonary fungal co-infection (20%). The isolation rate of Non-albicans Candida species out-numbered that of C. albicans. High prevalence of pulmonary fungal pathogens in our study, especially in cases where sputum for pulmonary tuberculosis was negative alerts, the need to employ conventional microbiology tests along with clinical and radiological evidence.

Recent Advances in the Treatment of Pulmonary Tuberculosis

1950 ◽  
Vol 34 (5) ◽  
pp. 1363-1380
Author(s):  
Theodore L. Badger ◽  
William E. Patton
Keyword(s):  
Pulmonary Tuberculosis ◽  
Recent Advances

Detection of Mycobacterium tuberculosis in smear negative sputum by PCR

2012 ◽  
Vol 6 (2) ◽  
pp. 2-6 ◽  
Author(s):  
Mohammad Jobayer ◽  
SM Shamsuzzaman ◽  
Kazi Zulfiquer Mamun
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Accurate Method ◽  
Major Health Problem ◽  
Major Health ◽  
Tuberculosis Patients ◽  
Diagnostic Potential ◽  
Total Death ◽  
Smear Negative ◽  
Negative Sputum

Pulmonary tuberculosis is a major health problem in Bangladesh that is responsible for about 7% of total death in a year. This study was conducted to isolate and identify Mycobacterium tuberculosis from sputum and to evaluate the efficacy of PCR as a modern diagnostic tool, for diagnosis of pulmonary tuberculosis, especially in the smear negative cases. One hundred and fifty suspected pulmonary TB patients (male/ female: 97/53) were included in this study. Single morning sputum was collected from each patient and diagnostic potential of PCR was compared with staining and culture. Twenty five (16.7%) sputum were positive by ZN stained smear. Among 125 smear negative samples, 13 (10.4%) yielded growth in culture in LJ media and 21 (16.8%) samples were positive by PCR. The sensitivity and specificity of PCR in smear negative cases was 100% and 92.9% respectively. Mean detection time in PCR was 24 hours. PCR detected M. tuberculosis in 21 smear negative and 9 culture negative samples. For diagnosis of tuberculosis in smear negative cases, PCR directly from sputum was a very sensitive and accurate method. In conclusion, PCR may be done, especially in clinically suspected pulmonary tuberculosis patients who remain negative by conventional methods.DOI: http://dx.doi.org/10.3329/bjmm.v6i2.19368 Bangladesh J Med Microbiol 2012; 06(02): 2-6

Comparison between ELISA and ICT- MycoDot in adult pulmonary tuberculosis

2007 ◽  
Vol 15 (1) ◽  
Author(s):  
AK Shamsuzzaman ◽  
S Akhter ◽  
SM Shamsuzzaman ◽  
A Siddique
Keyword(s):  
Pulmonary Tuberculosis
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