Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-Orbitrap mass spectrometers in drug discovery phase metabolite screening and identificationin vitro- amitriptyline and verapamil as model compounds

Timo Rousu; Jukka Herttuainen; Ari Tolonen

doi:10.1002/rcm.4465

Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-Orbitrap mass spectrometers in drug discovery phase metabolite screening and identificationin vitro- amitriptyline and verapamil as model compounds

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.4465 ◽

2010 ◽

Vol 24 (7) ◽

pp. 939-957 ◽

Cited By ~ 69

Author(s):

Timo Rousu ◽

Jukka Herttuainen ◽

Ari Tolonen

Keyword(s):

Drug Discovery ◽

Ion Trap ◽

Time Of Flight ◽

Linear Ion Trap ◽

Triple Quadrupole ◽

Model Compounds ◽

Mass Spectrometers ◽

Discovery Phase ◽

Metabolite Screening

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Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers

The Journal of Lipid Research ◽

10.1194/jlr.d800051-jlr200 ◽

2008 ◽

Vol 50 (8) ◽

pp. 1692-1707 ◽

Cited By ~ 283

Author(s):

Rebecca L. Shaner ◽

Jeremy C. Allegood ◽

Hyejung Park ◽

Elaine Wang ◽

Samuel Kelly ◽

...

Keyword(s):

Quantitative Analysis ◽

Ion Trap ◽

Linear Ion Trap ◽

Triple Quadrupole ◽

Mass Spectrometers ◽

Quadrupole Linear Ion Trap

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Identification of metabolites of anticancer candidate salinomycin using liquid chromatography coupled with quadrupole time-of-flight and hybrid triple quadrupole linear ion trap mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.8082 ◽

2018 ◽

Vol 32 (8) ◽

pp. 629-634 ◽

Cited By ~ 2

Author(s):

Małgorzata Olejnik ◽

Lidia Radko ◽

Piotr Jedziniak

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Ion Trap ◽

Time Of Flight ◽

Ion Trap Mass Spectrometry ◽

Linear Ion Trap ◽

Triple Quadrupole ◽

Quadrupole Linear Ion Trap

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Fragmentation study of imatinib and characterization of new imatinib metabolites by liquid chromatography–triple-quadrupole and linear ion trap mass spectrometers

Journal of Mass Spectrometry ◽

10.1002/jms.1002 ◽

2006 ◽

Vol 41 (3) ◽

pp. 390-404 ◽

Cited By ~ 39

Author(s):

Marc Marull ◽

Bertrand Rochat

Keyword(s):

Liquid Chromatography ◽

Ion Trap ◽

Linear Ion Trap ◽

Triple Quadrupole ◽

Mass Spectrometers

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A novel approach to perform metabolite screening during the quantitative LC-MS/MS analyses ofin vitro metabolic stability samples using a hybrid triple-quadrupole linear ion trap mass spectrometer

Journal of Mass Spectrometry ◽

10.1002/jms.917 ◽

2005 ◽

Vol 40 (10) ◽

pp. 1347-1356 ◽

Cited By ~ 59

Author(s):

Wilson Z. Shou ◽

Lisa Magis ◽

Austin C. Li ◽

Weng Naidong ◽

Matthew S. Bryant

Keyword(s):

Mass Spectrometer ◽

Ion Trap ◽

Metabolic Stability ◽

Linear Ion Trap ◽

Triple Quadrupole ◽

Ion Trap Mass Spectrometer ◽

Novel Approach ◽

Quadrupole Linear Ion Trap ◽

Metabolite Screening

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Quadrupole, Triple-Quadrupole, and Hybrid Linear Ion Trap Mass Spectrometers for Metabolite Analysis

Mass Spectrometry in Drug Metabolism and Pharmacokinetics ◽

10.1002/9780470409817.ch3 ◽

2008 ◽

pp. 123-157 ◽

Cited By ~ 1

Author(s):

Elliott B. Jones

Keyword(s):

Ion Trap ◽

Linear Ion Trap ◽

Triple Quadrupole ◽

Metabolite Analysis ◽

Mass Spectrometers

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Identification and quantification of phenolic compounds in Vitex negundo L. var. cannabifolia (Siebold et Zucc.) Hand.-Mazz. using liquid chromatography combined with quadrupole time-of-flight and triple quadrupole mass spectrometers

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2015.01.049 ◽

2015 ◽

Vol 108 ◽

pp. 11-20 ◽

Cited By ~ 19

Author(s):

Mingqing Huang ◽

Yiping Zhang ◽

Shuyu Xu ◽

Wen Xu ◽

Kedan Chu ◽

...

Keyword(s):

Liquid Chromatography ◽

Phenolic Compounds ◽

Time Of Flight ◽

Vitex Negundo ◽

Triple Quadrupole ◽

Quadrupole Mass ◽

Mass Spectrometers ◽

Identification And Quantification

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Metabolite Identification and Pharmacokinetic Profiling of Isoflavones from Black Soybean in Rats Using Ultrahigh-Performance Liquid Chromatography with Linear-Ion-Trap–Orbitrap and Triple-Quadrupole Tandem Mass Spectrometry

Journal of Agricultural and Food Chemistry ◽

10.1021/acs.jafc.8b04852 ◽

2018 ◽

Vol 66 (49) ◽

pp. 12941-12952 ◽

Cited By ~ 2

Author(s):

Juping Zhang ◽

Qianxiang Guo ◽

Meijin Wei ◽

Junqi Bai ◽

Juan Huang ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Ion Trap ◽

Metabolite Identification ◽

Linear Ion Trap ◽

Tandem Mass ◽

Triple Quadrupole ◽

Black Soybean ◽

Ultrahigh Performance Liquid Chromatography

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Hybrid triple quadrupole-linear ion trap mass spectrometry in fragmentation mechanism studies: application to structure elucidation of buspirone and one of its metabolites

Journal of Mass Spectrometry ◽

10.1002/jms.876 ◽

2005 ◽

Vol 40 (8) ◽

pp. 1017-1029 ◽

Cited By ~ 24

Author(s):

Mei-Yi Zhang ◽

Nadia Pace ◽

Edward H. Kerns ◽

Teresa Kleintop ◽

Natasha Kagan ◽

...

Keyword(s):

Mass Spectrometry ◽

Structure Elucidation ◽

Ion Trap ◽

Ion Trap Mass Spectrometry ◽

Linear Ion Trap ◽

Triple Quadrupole ◽

Fragmentation Mechanism ◽

Quadrupole Linear Ion Trap

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Cleaning Up Vegetable Samples Using a Modified “QuEChERS” Procedure for the Determination of 17 Plant Growth Regulator Residues by Ultra High Performance Liquid Chromatography–Triple Quadrupole Linear Ion Trap Mass Spectrometry

Food Analytical Methods ◽

10.1007/s12161-015-0397-y ◽

2016 ◽

Vol 9 (7) ◽

pp. 2097-2104 ◽

Cited By ~ 6

Author(s):

Shurui Cao ◽

Xue Zhou ◽

Cunxian Xi ◽

Bobin Tang ◽

Xiaowen Ding ◽

...

Keyword(s):

Plant Growth Regulator ◽

High Performance ◽

Ion Trap ◽

Ion Trap Mass Spectrometry ◽

Linear Ion Trap ◽

Triple Quadrupole ◽

Vegetable Samples ◽

Modified Quechers ◽

Quadrupole Linear Ion Trap

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Evaluation of multiple reaction monitoring cubed for the analysis of tachykinin related peptides in rat spinal cord using a hybrid triple quadrupole-linear ion trap mass spectrometer

Journal of Chromatography B ◽

10.1016/j.jchromb.2013.12.025 ◽

2014 ◽

Vol 947-948 ◽

pp. 164-167 ◽

Cited By ~ 3

Author(s):

Floriane Pailleux ◽

Francis Beaudry

Keyword(s):

Spinal Cord ◽

Mass Spectrometer ◽

Ion Trap ◽

Multiple Reaction Monitoring ◽

Linear Ion Trap ◽

Reaction Monitoring ◽

Triple Quadrupole ◽

Rat Spinal Cord ◽

Ion Trap Mass Spectrometer ◽

Quadrupole Linear Ion Trap

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