Quantum chemical structure-activity relationships on β-carbolines as natural monoamine oxidase inhibitors

1983 ◽  
Vol 23 (4) ◽  
pp. 1643-1652 ◽  
Author(s):  
M. Martin ◽  
F. Sanz ◽  
M. Campillo ◽  
L. Pardo ◽  
J. Perez ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Quantum Chemical ◽  
Chemical Structure ◽  
Monoamine Oxidase Inhibitors ◽  
Structure Activity Relationships ◽  
Structure Activity

Quantum-chemical Structure-Activity Relationships in carbamate insecticides

1995 ◽  
Vol 5 (4) ◽  
pp. 391-401 ◽  
Author(s):  
Juan S. Gomez-Jeria ◽  
Mario Ojeda-Vergara ◽  
Carlos Donoso-Espinoza
Keyword(s):  
Quantum Chemical ◽  
Chemical Structure ◽  
Structure Activity Relationships ◽  
Carbamate Insecticides ◽  
Structure Activity

A New Class of Potent Monoamine Oxidase Inhibitors. Chemistry and Structure-Activity Relationships of Aminoalkylhydrazines

1961 ◽  
Vol 26 (9) ◽  
pp. 3338-3341 ◽  
Author(s):  
JOHN H. BIEL ◽  
PATRICK A. NUHFER ◽  
ALEXANDER E. DRUKKER ◽  
THOMAS F. MITCHELL ◽  
A. C. CONWAY ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitors ◽  
Structure Activity Relationships ◽  
New Class ◽  
Structure Activity

scholarly journals Characterization of platinum(II) complexes exhibiting inhibitory activity against the 20S proteasome

2020 ◽  
Vol 7 (8) ◽  
pp. 200545
Author(s):  
Tatsuto Kiwada ◽  
Hiromu Katakasu ◽  
Serina Okumura ◽  
Akira Odani
Keyword(s):  
Inhibitory Activity ◽  
Chemical Structure ◽  
Competitive Inhibition ◽  
Proteasome Inhibitors ◽  
Platinum Complex ◽  
Platinum Complexes ◽  
Binding Mode ◽  
Structure Activity Relationships ◽  
Structure Activity

Proteasome inhibitors are useful for biochemical research and clinical treatment. In our previous study, we reported that the 4N-coordinated platinum complexes with anthracenyl ring and heterocycle exhibited proteasome-inhibitory activity. In the present study, the structure–activity relationships and characterization of these complexes were determined for the elucidation of the role of aromatic ligands. Lineweaver–Burk analysis revealed that the chemical structure of heterocycles affects the binding mode of platinum complexes. Platinum complexes with anthracenyl ring and pyridine showed competitive inhibition, although platinum complexes with anthracenyl ring and phenanthroline showed non-competitive inhibition. The structure–activity relationships demonstrated that anthracenyl moiety plays a crucial role in proteasome-inhibitory activity. The platinum complexes with naphthyl or phenyl rings exhibited lower inhibitory activities than the platinum complex with anthracenyl ring. The reactivity with N-acetylcysteine varied according to the chemical structure of complexes.

Inhibition of Monoamine Oxidase-B by Condensed Pyridazines and Pyrimidines:  Effects of Lipophilicity and Structure−Activity Relationships

1998 ◽  
Vol 41 (20) ◽  
pp. 3812-3820 ◽  
Author(s):  
Cosimo Altomare ◽  
Saverio Cellamare ◽  
Luciana Summo ◽  
Marco Catto ◽  
Angelo Carotti ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase B ◽  
Structure Activity Relationships ◽  
Structure Activity
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