Inhibition of Monoamine Oxidase-B by Condensed Pyridazines and Pyrimidines:  Effects of Lipophilicity and Structure−Activity Relationships

Cosimo Altomare; Saverio Cellamare; Luciana Summo; Marco Catto; Angelo Carotti; Ulrike Thull; Pierre-Alain Carrupt; Bernard Testa; Helen Stoeckli-Evans

doi:10.1021/jm981005y

Inhibition of Monoamine Oxidase-B by Condensed Pyridazines and Pyrimidines: Effects of Lipophilicity and Structure−Activity Relationships

Journal of Medicinal Chemistry ◽

10.1021/jm981005y ◽

1998 ◽

Vol 41 (20) ◽

pp. 3812-3820 ◽

Cited By ~ 51

Author(s):

Cosimo Altomare ◽

Saverio Cellamare ◽

Luciana Summo ◽

Marco Catto ◽

Angelo Carotti ◽

...

Keyword(s):

Monoamine Oxidase ◽

Monoamine Oxidase B ◽

Structure Activity Relationships ◽

Structure Activity

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Inhibition of Monoamine Oxidase-B by 5H-Indeno[1,2-c]pyridazines: Biological Activities, Quantitative Structure-Activity Relationships (QSARs) and 3D-QSARs

Journal of Medicinal Chemistry ◽

10.1021/jm00019a018 ◽

1995 ◽

Vol 38 (19) ◽

pp. 3874-3883 ◽

Cited By ~ 42

Author(s):

Silvia Kneubuehler ◽

Ulrike Thull ◽

Cosimo Altomare ◽

Vincenco Carta ◽

Patrick Gaillard ◽

...

Keyword(s):

Monoamine Oxidase ◽

Biological Activities ◽

Monoamine Oxidase B ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Understanding the Molecular Determinant of Reversible Human Monoamine Oxidase B Inhibitors Containing 2H-Chromen-2-One Core: Structure-Based and Ligand-Based Derived Three-Dimensional Quantitative Structure–Activity Relationships Predictive Models

Journal of Chemical Information and Modeling ◽

10.1021/acs.jcim.6b00608 ◽

2017 ◽

Vol 57 (4) ◽

pp. 787-814 ◽

Cited By ~ 13

Author(s):

Milan Mladenović ◽

Alexandros Patsilinakos ◽

Adele Pirolli ◽

Manuela Sabatino ◽

Rino Ragno

Keyword(s):

Monoamine Oxidase ◽

Predictive Models ◽

Three Dimensional ◽

Core Structure ◽

Monoamine Oxidase B ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Molecular Determinant ◽

Quantitative Structure Activity Relationships

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Structure–activity relationships in the inhibition of monoamine oxidase B by 1-methyl-3-phenylpyrroles

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2007.11.059 ◽

2008 ◽

Vol 16 (5) ◽

pp. 2463-2472 ◽

Cited By ~ 19

Author(s):

Modupe O. Ogunrombi ◽

Sarel F. Malan ◽

Gisella Terre’Blanche ◽

Neal Castagnoli ◽

Jacobus J. Bergh ◽

...

Keyword(s):

Monoamine Oxidase ◽

Monoamine Oxidase B ◽

Structure Activity Relationships ◽

Structure Activity

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ChemInform Abstract: Inhibition of Monoamine Oxidase-B by 5H-Indeno(1,2-c)pyridazines: Biological Activities, Quantitative Structure-Activity Relationships ( QSARs) and 3D-QSARs.

ChemInform ◽

10.1002/chin.199603159 ◽

2010 ◽

Vol 27 (3) ◽

pp. no-no

Author(s):

S. KNEUBUEHLER ◽

U. THULL ◽

C. ALTOMARE ◽

V. CARTA ◽

P. GAILLARD ◽

...

Keyword(s):

Monoamine Oxidase ◽

Biological Activities ◽

Monoamine Oxidase B ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Structure-Activity Relationships in the Oxidation of Benzylamine Analogs by Bovine Liver Mitochondrial Monoamine Oxidase B

Biochemistry ◽

10.1021/bi00189a011 ◽

1994 ◽

Vol 33 (23) ◽

pp. 7088-7098 ◽

Cited By ~ 102

Author(s):

Mark C. Walker ◽

Dale E. Edmondson

Keyword(s):

Monoamine Oxidase ◽

Bovine Liver ◽

Monoamine Oxidase B ◽

Structure Activity Relationships ◽

Structure Activity ◽

Mitochondrial Monoamine Oxidase

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QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS IN THE OXIDATION OF BENZYLAMINE ANALOGUES BY BOVINE LIVER MONOAMINE OXIDASE B

Flavins and Flavoproteins 1993 ◽

10.1515/9783110885774-021 ◽

1994 ◽

pp. 109-116

Keyword(s):

Monoamine Oxidase ◽

Bovine Liver ◽

Monoamine Oxidase B ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Thiazole Derivatives as Inhibitors of Purified Bovine Liver Mitochondrial Monoamine Oxidase-B: Structure-Activity Relationships and Theoretical Study

Journal of Enzyme Inhibition ◽

10.3109/14756369909030324 ◽

1999 ◽

Vol 14 (4) ◽

pp. 307-321 ◽

Cited By ~ 7

Author(s):

Antonio Cambria ◽

Antonio Raudino ◽

Athina Geronikaki ◽

Giuseppe Buemi ◽

Giuseppina Raciti ◽

...

Keyword(s):

Monoamine Oxidase ◽

Theoretical Study ◽

Bovine Liver ◽

Monoamine Oxidase B ◽

Thiazole Derivatives ◽

Structure Activity Relationships ◽

Structure Activity ◽

Mitochondrial Monoamine Oxidase

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Structure activity studies of the substrate binding site in monoamine oxidase B

Biochimie ◽

10.1016/0300-9084(96)88179-x ◽

1995 ◽

Vol 77 (7-8) ◽

pp. 643-650 ◽

Cited By ~ 4

Author(s):

D.E. Edmondson

Keyword(s):

Monoamine Oxidase ◽

Binding Site ◽

Substrate Binding ◽

Monoamine Oxidase B ◽

Substrate Binding Site ◽

Structure Activity

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Monoamine oxidase inhibition in brain and liver produced by β-carbolines: structure-activity relationships and substrate specificity

Biochemical Pharmacology ◽

10.1016/0006-2952(77)90007-7 ◽

1977 ◽

Vol 26 (21) ◽

pp. 1991-1996 ◽

Cited By ~ 149

Author(s):

Neil S. Buckholtz ◽

William O. Boggan

Keyword(s):

Monoamine Oxidase ◽

Substrate Specificity ◽

Monoamine Oxidase Inhibition ◽

Structure Activity Relationships ◽

Structure Activity ◽

Oxidase Inhibition

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Probing the Mechanism of Bioactivation of MPTP Type Analogs by Monoamine Oxidase B: Structure-Activity Studies on Substituted 4-Phenoxy-, 4-Phenyl-, and 4-Thiophenoxy-1-cyclopropyl-1,2,3,6-tetrahydropyridines

Chemical Research in Toxicology ◽

10.1021/tx00047a010 ◽

1995 ◽

Vol 8 (5) ◽

pp. 703-710 ◽

Cited By ~ 21

Author(s):

John M. Rimoldi ◽

You-Xiong Wang ◽

Sandeep K. Nimkar ◽

Simon H. Kuttab ◽

Andrea H. Anderson ◽

...

Keyword(s):

Monoamine Oxidase ◽

Monoamine Oxidase B ◽

Structure Activity

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