Kopsanone inhibits proliferation and migration of invasive colon cancer cells

2021 ◽  
Author(s):  
Daniella Paiva Bonfim ◽  
Celso Vataru Nakamura ◽  
João Xavier Araújo Júnior ◽  
Greisiele Lorena Pessini ◽  
Paulo Emílio Correa Leite ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals LncRNA DSCAM-AS1 Promotes Colon Cancer Cells Proliferation and Migration via Regulating the miR-204/SOX4 Axis

2020 ◽  
Vol Volume 12 ◽  
pp. 4347-4356
Author(s):  
Canrong Lu ◽  
Tianyu Xie ◽  
Xin Guo ◽  
Di Wu ◽  
Shuo Li ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals MicroRNA 375 regulates proliferation and migration of colon cancer cells by suppressing the CTGF-EGFR signaling pathway

2017 ◽  
Vol 141 (8) ◽  
pp. 1614-1629 ◽  
Author(s):  
Khondoker Jahengir Alam ◽  
Ji-Su Mo ◽  
Seol-Hee Han ◽  
Won-Cheol Park ◽  
Hun-Soo Kim ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Colon Cancer Cells ◽  
Egfr Signaling ◽  
Egfr Signaling Pathway ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals FYN is required for ARHGEF16 to promote proliferation and migration in colon cancer cells

2020 ◽  
Vol 11 (8) ◽  
Author(s):  
Bei Yu ◽  
Linlin Xu ◽  
Limin Chen ◽  
Yao Wang ◽  
Hongying Jiang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Knockdown of ISOC1 inhibits the proliferation and migration and induces the apoptosis of colon cancer cells through the AKT/GSK-3β pathway

2019 ◽  
Vol 41 (8) ◽  
pp. 1123-1133 ◽  
Author(s):  
Bo Gao ◽  
Lianmei Zhao ◽  
Feifei Wang ◽  
Hanyu Bai ◽  
Jing Li ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Critical Role ◽  
Disease Free Survival ◽  
Clinical Samples ◽  
Colon Cancer Cells ◽  
And Migration ◽  
Gsk 3Β ◽  
Proliferation And Migration

Abstract Isochorismatase domain-containing 1 (ISOC1) is a coding gene that contains an isochorismatase domain. The precise functions of ISOC1 in humans have not been clarified; however, studies have speculated that it may be involved in unknown metabolic pathways. Currently, it is reported that ISOC1 is associated with breast cancer. In this research, the aim is to investigate the critical role of ISOC1 in colorectal cancer (CRC) and to explore its biological function and mechanism in colon cancer cells. In 106 paired clinical samples, we found that the levels of ISOC1 expression were widely increased in cancer tissues compared with matched adjacent non-tumor tissues and that increased expression of ISOC1 was significantly associated with tumor size, tumor invasion, local lymph node metastasis and Tumor, Node and Metastasis (TNM) stage. Moreover, higher expression levels of ISOC1 were correlated with shorter disease-free survival in patients 2 years after surgery. In vitro, ISOC1 knockdown inhibited the proliferation and migration and induced the apoptosis of colon cancer cells, and in vivo, the xenograft tumors were also inhibited by ISOC1 silencing. We also used MTS, Transwell and cell apoptosis assays to confirm that ISOC1 plays a critical role in regulating the biological functions of colon cancer cells through the AKT/GSK-3β pathway. Additionally, the results of confocal microscopy and western blot analysis indicated that ISOC1 knockdown could promote p-STAT1 translocation to the nucleus.

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