Studies on psychopharmacological activity ofAndrographis paniculata extract

2001 ◽  
Vol 15 (3) ◽  
pp. 253-256 ◽  
Author(s):  
Subhash C. Mandal ◽  
A. K. Dhara ◽  
B. C. Maiti
Keyword(s):  
Psychopharmacological Activity

Some Aspects of the Psychopharmacological Activity of Maprotiline (Ludiomil®): Effects of Single and Repeated Treatments

1978 ◽  
Vol 6 (6) ◽  
pp. 421-429 ◽  
Author(s):  
A Delini-Stula ◽  
E Radeke ◽  
A Vassout
Keyword(s):  
Nervous System ◽  
Chronic Treatment ◽  
Conditioned Fear ◽  
Conditioned Avoidance ◽  
Repeated Treatment ◽  
Antidepressant Effects ◽  
The Central Nervous System ◽  
Pre Treatment ◽  
High Doses ◽  
Psychopharmacological Activity

Three different aspects of the psychopharmacological activity of the antidepressant maprotiline were investigated: its influence on serotoninergic functions the effects produced by chronic treatment its central nervous depressant and anxiolytic properties. Study of the effects of maprotiline on 5-HTP-induced head-twitch in mice pre-treated with pargyline or on hyperpyrexia in rats provided no evidence that the drug interferes with serotonin-mediated functions in the central nervous system even after quite high doses. These findings corroborate the results of extensive neurobiochemical investigations, which failed to demonstrate any influence of maprotiline on the metabolism of serotonin. Chronic studies showed that classical effects of maprotiline such as antagonism against reserpine-induced ptosis or tetrabenazine-induced catalepsy do not change in their intensity after daily administration of the drugs in a dose of 30 mg/kg p.o.for 11 days. A new component of the action of the compound, not detectable after one single dose, seems to appear, however, after repeated treatment (8 days). This effect is manifested in the restoration of conditioned avoidance behaviour after its suppression by pre-treatment with reserpine. The same effect is produced by imipramine. It is suggested that this restorative effect may be due to an additional activation of the dopaminergic nervous system and may have a bearing on the appearance of clinical antidepressant effects. Maprotiline was found to potentiate central nervous depressant effects of drugs like chlorpromazine, phenobarbitone and propranolol. This affords further confirmation that, in addition to its antidepressant qualities, it possesses sedative actions. An anxiolytic component was also demonstrated in rats in which maprotiline suppressed the conditioned, fear-induced rise in body-temperature.

ChemInform Abstract: Synthesis and Psychopharmacological Activity of Benzhydrylglycine Derivatives.

ChemInform ◽  
1989 ◽  
Vol 20 (36) ◽  
Author(s):  
T. A. VORONINA ◽  
I. KH. RAKHMANKULOVA ◽  
O. P. RUDENKO ◽  
A. I. LISITSYNA ◽  
O. P. POVOLOTSKAYA
Keyword(s):  
Psychopharmacological Activity

Psychopharmacological activity of anaphylatoxin C3a in rat hypothalamus

1983 ◽  
Vol 5 (3) ◽  
pp. 305-316 ◽  
Author(s):  
Nicole Schupf ◽  
Curtis A. Williams ◽  
Tony E. Hugli ◽  
Jaclinn Cox
Keyword(s):  
Rat Hypothalamus ◽  
Anaphylatoxin C3a ◽  
Psychopharmacological Activity

ChemInform Abstract: Synthesis and Psychopharmacological Activity of N-(4-Hydroxy-4-methyl- 3-tetrahydropyranyl) Derivatives of Amino Acids.

ChemInform ◽  
2010 ◽  
Vol 23 (26) ◽  
pp. no-no
Author(s):  
G. V. KOVALEV ◽  
S. A. VASIL'EVA ◽  
V. A. SAZHIN ◽  
I. P. KULESHOVA ◽  
I. N. BATALINA
Keyword(s):  
Amino Acids ◽  
Derivatives Of ◽  
Psychopharmacological Activity

DESIGN, SYNTHESIS AND PSYCHOPHARMACOLOGICAL ACTIVITY OF QUINOLIN-2-ONE DERIVATIVES

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (08) ◽  
pp. 21-26
Author(s):  
Abreu Emmie de ◽  
S. K Chandavarkar ◽  
B. S Biradar ◽  
Bobde S. S. ◽  
S. P. Naik ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Antidepressant Activity ◽  
Docking Studies ◽  
Mass Spectral Data ◽  
Design Synthesis ◽  
Molegro Virtual Docker ◽  
Mass Spectral ◽  
Phosphorous Oxychloride ◽  
Immobility Time ◽  
Psychopharmacological Activity

Starting material 4-hydroxy-1-phenyl/methyl-quinolin-2-(1H)-one was treated with phosphorous oxychloride and then subjected to Mannich reaction to yield title 4-chloro-1-phenyl/methyl-3-[3- (substituted) propanoyl] quinolin-2(1H)-one derivatives compounds IIa (1-7)/ IIb (1-7). Molecular docking studies of the compounds were carried out using Molegro Virtual Docker. All the synthesized compounds were characterized by IR, 1H-NMR and Mass Spectral data and were tested for their antidepressant activity. Amongst the synthesized compounds, compound 4-chloro-1-phenyl-3-[3-(morpholinopropanoyl] quinolin-2(1H)-one [IIa4] was found to show the most potent antidepressant activity with immobility time of 98.17± 4.806. Compound 4-chloro-1-phenyl-3-[3-(4- methylpiperazin-1-yl) propanoyl] quinolin-2(1H)- one [IIa 3] and 4-chloro-1-methyl-3-[3-(pyrrolidin-1-yl) propanoyl] quinolin-2(1H)-one [IIb 2] showed moderate antidepressant activity with immobility time of 126.5 ± 1.945s and 120.3 ± 2.376s, respectively, compared to standard imipramine.

Psychopharmacological Activity of Ring- and Side Chain-Substituted β-Phenethylamines1

1958 ◽  
Vol 23 (12) ◽  
pp. 1979-1984 ◽  
Author(s):  
F. BENINGTON ◽  
R. D. MORIN ◽  
LELAND C. CLARK ◽  
R. PHYLLIS FOX
Keyword(s):  
Side Chain ◽  
Psychopharmacological Activity

Synthesis and psychopharmacological activity of N-(4-hydroxy-4-methyl-3-tetrahydropyranyl) derivatives of aminoacids

1991 ◽  
Vol 25 (2) ◽  
pp. 86-89
Author(s):  
G. V. Kovalev ◽  
S. A. Vasil'eva ◽  
V. A. Sazhin ◽  
I. P. Kuleshova ◽  
I. N. Batalina
Keyword(s):  
Derivatives Of ◽  
Psychopharmacological Activity

Synthesis and psychopharmacological activity of benzhydryl glycine derivatives

1989 ◽  
Vol 23 (1) ◽  
pp. 30-32
Author(s):  
T. A. Voronina ◽  
I. Kh. Rakhmankulova ◽  
O. P. Rudenko ◽  
A. I. Lisitsyna ◽  
O. P. Povolotskaya
Keyword(s):  
Glycine Derivatives ◽  
Psychopharmacological Activity

scholarly journals PSYCHOPHARMACOLOGICAL ACTIVITY;

2012 ◽  
Vol 19 (02) ◽  
pp. 264-269
Author(s):  
SAIMA AHMED ◽  
Muhammad ASADULLAH
Keyword(s):  
Tap Water ◽  
Screening Method ◽  
Wide Range ◽  
Psychotropic Agents ◽  
Strong Action ◽  
The Central Nervous System ◽  
Cns Activity ◽  
Brain And Behavior ◽  
And Behavior ◽  
Psychopharmacological Activity

Objective: The purpose of this study was to screen some herbal medicine as psychotropic drugs those has strong modulatingeffect on brain and behavior. Material & methods: Herbal drug Reserpine, Nux- Vomica, Anacardium and Chlorpromazine with a wide range ofpharmacological actions. In our present study, we evaluate the effectiveness of these drugs as Psychotropic agents and accessed bybiochemical-parameters. Rats (weighing 180-250g) and Mice (22-32g) either sex were used in this study. One group was kept as control fordrugs. Mice were kept under room temperature. Tap-water was allowed ad-Libitum. Animals were observed during and after 21 days. A tabletcrushed in 10ml of water, 1cc was given. Screening method used was swimming induced-despair. Results: Among these, Strychnos Nux-Vomica has strong action on cholinergic system, CNS activity and observed as an antispasmodic. Rauwolfia serpentine is an active alkaloidparticularly present in reserpine are used to treat essential hypertension and in certain neuropsychiatry disorders. It has sedative andtranquilizing effects, as it depletes catecholamine from the central nervous system. Keeping in view, the medicinal importance of these herbs,our present study was designed to screen these herbs as for CNS activity on Albino mice and rats.

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