Synthesis and psychopharmacological activity of benzhydryl glycine derivatives

1989 ◽  
Vol 23 (1) ◽  
pp. 30-32
Author(s):  
T. A. Voronina ◽  
I. Kh. Rakhmankulova ◽  
O. P. Rudenko ◽  
A. I. Lisitsyna ◽  
O. P. Povolotskaya
Keyword(s):  
Glycine Derivatives ◽  
Psychopharmacological Activity

ChemInform Abstract: Iron-Catalyzed Synthesis of Glycine Derivatives via Carbon-Nitrogen Bond Cleavage Using Diazoacetate.

ChemInform ◽  
2011 ◽  
Vol 42 (14) ◽  
pp. no-no
Author(s):  
Yoichiro Kuninobu ◽  
Mitsumi Nishi ◽  
Kazuhiko Takai
Keyword(s):  
Bond Cleavage ◽  
Glycine Derivatives ◽  
Nitrogen Bond

Photooxidation at Platinum Colloidal TiO2 Aqueous-Solution Interfaces. I. Ethylenediaminetetraacetic Acid and Related-Compounds

1986 ◽  
Vol 39 (5) ◽  
pp. 757 ◽  
Author(s):  
DN Furlong ◽  
D Wells ◽  
WHF Sasse
Keyword(s):  
Carbon Dioxide ◽  
Aqueous Solution ◽  
Ethylenediaminetetraacetic Acid ◽  
Oxidation Potential ◽  
Illumination Time ◽  
Carbonium Ions ◽  
Production Of Hydrogen ◽  
Glycine Derivatives ◽  
Lactic Acids ◽  
Exhaustive Oxidation

The photooxidation of ethylenediaminetetraacetic acid ( edta ) and related glycine derivatives, at Pt/TiO2/aqueous solution interfaces, has been monitored via the production of hydrogen and carbon dioxide. Yields are consistent with the exhaustive oxidation of methoxycarbonyl groups and the rate varied with the number and distribution of such groups. A photooxidation pathway is proposed which involves the oxidation of intermediate carbonium ions. Plausible molecular intermediates, such as formic acid and formaldehyde in the case of edta , have been shown in separate experiments to be photooxidized according to the proposed pathway. The maximum rate of oxidation for each donor depends on its oxidation potential and its tendency to adsorb on TiO2 surfaces. Desorption due to pH increase, as well as consumption of the donor, causes the rate to decline rapidly with illumination time. Acetic and malonic acids gave some hydrogen but underwent mainly (> c. 80%) photo-Kolbe decarboxylation to yield carbon dioxide and methane. By contrast the oxidation of oxomalonic, pyruvic and lactic acids proceeded mainly via a H2 producing pathway similar to that established for edta. The oxidation of pyruvic and lactic acids ceased at a yield of one mole of CO2 per mole of acid.

Iron-Catalyzed Cyanoalkylation of Glycine Derivatives Promoted by Pyridine-Oxazoline Ligands

ACS Catalysis ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 4288-4293
Author(s):  
Dengfu Lu ◽  
Jiajia Cui ◽  
Sen Yang ◽  
Yuefa Gong
Keyword(s):  
Glycine Derivatives ◽  
Oxazoline Ligands

Some Aspects of the Psychopharmacological Activity of Maprotiline (Ludiomil®): Effects of Single and Repeated Treatments

1978 ◽  
Vol 6 (6) ◽  
pp. 421-429 ◽  
Author(s):  
A Delini-Stula ◽  
E Radeke ◽  
A Vassout
Keyword(s):  
Nervous System ◽  
Chronic Treatment ◽  
Conditioned Fear ◽  
Conditioned Avoidance ◽  
Repeated Treatment ◽  
Antidepressant Effects ◽  
The Central Nervous System ◽  
Pre Treatment ◽  
High Doses ◽  
Psychopharmacological Activity

Three different aspects of the psychopharmacological activity of the antidepressant maprotiline were investigated: its influence on serotoninergic functions the effects produced by chronic treatment its central nervous depressant and anxiolytic properties. Study of the effects of maprotiline on 5-HTP-induced head-twitch in mice pre-treated with pargyline or on hyperpyrexia in rats provided no evidence that the drug interferes with serotonin-mediated functions in the central nervous system even after quite high doses. These findings corroborate the results of extensive neurobiochemical investigations, which failed to demonstrate any influence of maprotiline on the metabolism of serotonin. Chronic studies showed that classical effects of maprotiline such as antagonism against reserpine-induced ptosis or tetrabenazine-induced catalepsy do not change in their intensity after daily administration of the drugs in a dose of 30 mg/kg p.o.for 11 days. A new component of the action of the compound, not detectable after one single dose, seems to appear, however, after repeated treatment (8 days). This effect is manifested in the restoration of conditioned avoidance behaviour after its suppression by pre-treatment with reserpine. The same effect is produced by imipramine. It is suggested that this restorative effect may be due to an additional activation of the dopaminergic nervous system and may have a bearing on the appearance of clinical antidepressant effects. Maprotiline was found to potentiate central nervous depressant effects of drugs like chlorpromazine, phenobarbitone and propranolol. This affords further confirmation that, in addition to its antidepressant qualities, it possesses sedative actions. An anxiolytic component was also demonstrated in rats in which maprotiline suppressed the conditioned, fear-induced rise in body-temperature.

Copper-catalyzed oxidative cyclization of glycine derivatives toward 2-substituted benzoxazoles

2021 ◽  
Vol 19 (7) ◽  
pp. 1616-1619
Author(s):  
Shan Liu ◽  
Zhi-Qiang Zhu ◽  
Zhi-Yu Hu ◽  
Juan Tang ◽  
En Yuan
Keyword(s):  
Intramolecular Cyclization ◽  
Cross Coupling ◽  
Oxidative Cyclization ◽  
Short Peptides ◽  
Glycine Derivatives

A novel and direct intramolecular cyclization of glycine derivatives involving short peptides to 2-substituted benzoxazoles via copper-catalyzed oxidative C–H/O–H cross-coupling was described.

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