Quercetin ameliorates reactive oxygen species generation, inflammation, mucus depletion, goblet disintegration, and tumor multiplicity in colon cancer: Probable role of adenomatous polyposis coli, β‐catenin

2020 ◽  
Author(s):  
Alpa Shree ◽  
Johirul Islam ◽  
Sarwat Sultana
Keyword(s):  
Reactive Oxygen Species ◽  
Colon Cancer ◽  
Adenomatous Polyposis Coli ◽  
Reactive Oxygen Species Generation ◽  
Oxygen Species ◽  
Adenomatous Polyposis ◽  
Polyposis Coli ◽  
Tumor Multiplicity ◽  
Probable Role

scholarly journals Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction of an Ectopic Dorsoanterior Axis

1997 ◽  
Vol 136 (2) ◽  
pp. 411-420 ◽  
Author(s):  
Kris Vleminckx ◽  
Ellen Wong ◽  
Kathy Guger ◽  
Bonnee Rubinfeld ◽  
Paul Polakis ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumor Suppressor ◽  
Adenomatous Polyposis Coli ◽  
Protein A ◽  
Homeobox Gene ◽  
Xenopus Embryo ◽  
Adenomatous Polyposis ◽  
Polyposis Coli ◽  
Human Colon Cancer ◽  
Signaling Activity

Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene are linked to both familial and sporadic human colon cancer. So far, a clear biological function for the APC gene product has not been determined. We assayed the activity of APC in the early Xenopus embryo, which has been established as a good model for the analysis of the signaling activity of the APC-associated protein β-catenin. When expressed in the future ventral side of a four-cell embryo, full-length APC induced a secondary dorsoanterior axis and the induction of the homeobox gene Siamois. This is similar to the phenotype previously observed for ectopic β-catenin expression. In fact, axis induction by APC required the availability of cytosolic β-catenin. These results indicate that APC has signaling activity in the early Xenopus embryo. Signaling activity resides in the central domain of the protein, a part of the molecule that is missing in most of the truncating APC mutations in colon cancer. Signaling by APC in Xenopus embryos is not accompanied by detectable changes in expression levels of β-catenin, indicating that it has direct positive signaling activity in addition to its role in β-catenin turnover. From these results we propose a model in which APC acts as part of the Wnt/β-catenin signaling pathway, either upstream of, or in conjunction with, β-catenin.

scholarly journals Genes regulating membrane-associated E-cadherin and proliferation in adenomatous polyposis coli mutant colon cancer cells: High content siRNA screen

PLoS ONE ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. e0240746
Author(s):  
Lauren E. King ◽  
Hui-Hua Zhang ◽  
Cathryn M. Gould ◽  
Daniel W. Thomas ◽  
Lachlan W. Whitehead ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Adenomatous Polyposis Coli ◽  
Adenomatous Polyposis ◽  
Colon Cancer Cells ◽  
Polyposis Coli ◽  
Sirna Screen ◽  
Coli Mutant ◽  
E Cadherin

scholarly journals Haploinsufficiency of Casitas B-Lineage Lymphoma Augments the Progression of Colon Cancer in the Background of Adenomatous Polyposis Coli Inactivation

2020 ◽  
Vol 190 (3) ◽  
pp. 602-613
Author(s):  
Sean Richards ◽  
Joshua Walker ◽  
Masako Nakanishi ◽  
Mostafa Belghasem ◽  
Chimera Lyle ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Adenomatous Polyposis Coli ◽  
Adenomatous Polyposis ◽  
Polyposis Coli ◽  
B Lineage

The effects of genistein and daidzein on cell proliferation kinetics in HT29 colon cancer cells: the expression of CTNNBIP1 (β-catenin), APC (adenomatous polyposis coli) and BIRC5 (survivin)

Human Cell ◽  
2014 ◽  
Vol 27 (2) ◽  
pp. 78-84 ◽  
Author(s):  
Sandra Regina Lepri ◽  
Leonardo Campos Zanelatto ◽  
Patrícia Benites Gonçalves da Silva ◽  
Daniele Sartori ◽  
Lucia Regina Ribeiro ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Adenomatous Polyposis Coli ◽  
Adenomatous Polyposis ◽  
Colon Cancer Cells ◽  
Polyposis Coli ◽  
Proliferation Kinetics

scholarly journals Role of Nox4 and Nox2 in Hyperoxia-Induced Reactive Oxygen Species Generation and Migration of Human Lung Endothelial Cells

2009 ◽  
Vol 11 (4) ◽  
pp. 747-764 ◽  
Author(s):  
Srikanth Pendyala ◽  
Irina A Gorshkova ◽  
Peter V. Usatyuk ◽  
Donghong He ◽  
Arjun Pennathur ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Endothelial Cells ◽  
Human Lung ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Lung Endothelial Cells ◽  
And Migration

Role of metal-induced reactive oxygen species generation in lung responses caused by residual oil fly ash

2003 ◽  
Vol 28 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Anthony B. Lewis ◽  
Michael D. Taylor ◽  
Jenny R. Roberts ◽  
Stephen S. Leonard ◽  
Xianglin Shi ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Fly Ash ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Residual Oil ◽  
Residual Oil Fly Ash ◽  
Oil Fly Ash
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