scholarly journals Assembly of the Base Excision Repair Complex on Abasic DNA and Role of Adenomatous Polyposis Coli on Its Functional Activity

Biochemistry ◽  
2011 ◽  
Vol 50 (11) ◽  
pp. 1901-1909 ◽  
Author(s):  
Aruna S. Jaiswal ◽  
Satya Narayan
Keyword(s):  
Adenomatous Polyposis Coli ◽  
Base Excision Repair ◽  
Functional Activity ◽  
Excision Repair ◽  
Adenomatous Polyposis ◽  
Polyposis Coli ◽  
Base Excision

Structure/Function Analysis of the Interaction of Adenomatous Polyposis Coli with DNA Polymerase β and Its Implications for Base Excision Repair†

Biochemistry ◽  
2007 ◽  
Vol 46 (49) ◽  
pp. 13961-13974 ◽  
Author(s):  
Ramesh Balusu ◽  
Aruna S. Jaiswal ◽  
Melissa L. Armas ◽  
Chanakya N. Kundu ◽  
Linda B. Bloom ◽  
...  
Keyword(s):  
Structure Function ◽  
Adenomatous Polyposis Coli ◽  
Dna Polymerase ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Function Analysis ◽  
Adenomatous Polyposis ◽  
Polyposis Coli ◽  
Dna Polymerase Β ◽  
Base Excision

scholarly journals Mechanism of Adenomatous Polyposis Coli (APC)-Mediated Blockage of Long-Patch Base Excision Repair†

Biochemistry ◽  
2006 ◽  
Vol 45 (51) ◽  
pp. 15903-15914 ◽  
Author(s):  
Aruna S. Jaiswal ◽  
Ramesh Balusu ◽  
Melissa L. Armas ◽  
Chanakya N. Kundu ◽  
Satya Narayan
Keyword(s):  
Adenomatous Polyposis Coli ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Adenomatous Polyposis ◽  
Polyposis Coli ◽  
Base Excision

MutYH (MYH) and colorectal cancer

2005 ◽  
Vol 33 (4) ◽  
pp. 679-683 ◽  
Author(s):  
J.R. Sampson ◽  
S. Jones ◽  
S. Dolwani ◽  
J.P. Cheadle
Keyword(s):  
Excision Repair ◽  
Adenomatous Polyposis ◽  
Polyposis Coli ◽  
Ras Genes ◽  
Stable Product ◽  
Base Excision ◽  
Mutyh Associated Polyposis ◽  
Inherited Mutations ◽  
Oxidative Damage To Dna

MAP (MutYH-associated polyposis) is a recently described colorectal adenoma and carcinoma predisposition syndrome that is associated with biallelic-inherited mutations of the human MutY homologue gene, MutYH. MutYH is often also termed MYH. MAP tumours display a mutational signature of somatic guanine-to-thymine transversion mutations in the adenomatous polyposis coli and K-ras genes, reflecting the normal role of MutYH in the base excision repair of adenines misincorporated opposite 7,8-dihydro-8-oxoguanine, a prevalent and stable product of oxidative damage to DNA. However, the full genetic pathway of MAP tumorigenesis has not been elucidated.

Sign in / Sign up

Export Citation Format

Share Document