Apple polyphenols extract alleviated dextran sulfate sodium‐induced ulcerative colitis in C57BL /6 male mice by restoring bile acid metabolism disorder and gut microbiota dysbiosis

2020 ◽  
Author(s):  
Fang Liu ◽  
Xinjing Wang ◽  
Deming Li ◽  
Yuan Cui ◽  
Xinli Li
Keyword(s):  
Ulcerative Colitis ◽  
Bile Acid ◽  
Gut Microbiota ◽  
Dextran Sulfate ◽  
Acid Metabolism ◽  
Dextran Sulfate Sodium ◽  
Bile Acid Metabolism ◽  
Male Mice ◽  
Metabolism Disorder ◽  
Gut Microbiota Dysbiosis

scholarly journals Gut Microbiota Dysbiosis Associated with Bile Acid Metabolism in Neonatal Cholestasis Disease

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Meng Li ◽  
Sixiang Liu ◽  
Mingying Wang ◽  
Hongwei Hu ◽  
Jianwen Yin ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Neonatal Cholestasis ◽  
Gut Microbiota Dysbiosis

scholarly journals Armillaria luteo-virens Sacc Ameliorates Dextran Sulfate Sodium Induced Colitis through Modulation of Gut Microbiota and Microbiota-Related Bile Acids

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3926
Author(s):  
Nana Zhang ◽  
Jianlin Liu ◽  
Xinxin Guo ◽  
Shuying Li ◽  
Fengzhong Wang ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Underlying Mechanism ◽  
Nutritional Intervention ◽  
Farnesoid X Receptor ◽  
Bile Acid Metabolism ◽  
Rrna Gene ◽  
Novel Approach

Armillaria luteo-virens Sacc (ALS) is a rare wild Chinese medicinal and edible basidiomycete. However, its protective effect on intestinal functions and the underlying mechanism is still unknown. This work explored the improvement of dextran sulfate sodium (DSS)-induced colitis by ALS. ALS supplementation markedly improved colitis symptoms, gut barrier integrity, and goblet loss in DSS-treated mice. In addition, ALS inhibited colonic inflammation through the inhibition/activation of the mitogen-activated protein kinases/NF-κB signaling pathway. The 16S rRNA gene-based microbiota analysis revealed that ALS altered the gut microbiota composition, decreasing the richness of Enterobacteriaceae and increasing the abundance of Lactobacillaceae. The bile-acid-targeted metabolomic analysis showed that ALS recovered the microbial bile acid metabolism in the gut, enabling the activation of the farnesoid X receptor signaling by these acids, thus maintaining the intestinal homeostasis. Importantly, broad-spectrum antibiotic treatment reduced the efficacy of ALS-induced protection from colitis. Overall, our findings suggest that ALS may represent a novel approach in the nutritional intervention to prevent colitis.

Combined use of epigallocatechin-3-gallate (EGCG) and caffeine in low doses exhibits marked anti-obesity synergy through regulation of gut microbiota and bile acid metabolism

2021 ◽  
Author(s):  
Ming-zhi Zhu ◽  
Fang Zhou ◽  
Jian Ouyang ◽  
Qi-ye Wang ◽  
Yi-long Li ◽  
...  
Keyword(s):  
Bile Acid ◽  
Synergistic Effect ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Low Doses ◽  
Combined Use

Combined use of epigallocatechin-3-gallate (EGCG) and caffeine in low doses exhibits marked anti-obesity synergy. The synergistic effect may be attributed to regulation of gut microbiota and BA metabolism.

Desmethylbellidifolin Attenuates Dextran Sulfate Sodium-Induced Colitis: Impact on Intestinal Barrier, Intestinal Inflammation and Gut Microbiota

Planta Medica ◽  
2021 ◽  
Author(s):  
Jiaqi Wu ◽  
Yuzheng Wu ◽  
Yue Chen ◽  
Mengyang Liu ◽  
Haiyang Yu ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Gut Microbiota ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Intestinal Inflammation ◽  
Activity Index ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Function Evaluation ◽  
Biological Drugs

AbstractUlcerative colitis has been recognized as a chronic inflammatory disease predominantly disturbing the colon and rectum. Clinically, the aminosalicylates, steroids, immunosuppressants, and biological drugs are generally used for the treatment of ulcerative colitis at different stages of disease progression. However, the therapeutic efficacy of these drugs does not satisfy the patients due to the frequent drug resistance. Herein, we reported the anti-ulcerative colitis activity of desmethylbellidifolin, a xanthone isolated from Gentianella acuta, in dextran sulfate sodium-induced colitis in mice. C57BL/6 mice were treated with 2% dextran sulfate sodium in drinking water to induce acute colitis. Desmethylbellidifolin or balsalazide sodium was orally administrated once a day. Biological samples were collected for immunohistological analysis, intestinal barrier function evaluation, cytokine measurement, and gut microbiota analysis. The results revealed that desmethylbellidifolin alleviated colon shortening and body weight loss in dextran sulfate sodium-induced mice. The disease activity index was also lowered by desmethylbellidifolin after 9 days of treatment. Furthermore, desmethylbellidifolin remarkably ameliorated colonic inflammation through suppressing the expression of interleukin-6 and tumor necrosis factor-α. The intestinal epithelial barrier was strengthened by desmethylbellidifolin through increasing levels of occludin, ZO-1, and claudins. In addition, desmethylbellidifolin modulated the gut dysbiosis induced by dextran sulfate sodium. These findings suggested that desmethylbellidifolin effectively improved experimental ulcerative colitis, at least partly, through maintaining intestinal barrier integrity, inhibiting proinflammatory cytokines, and modulating dysregulated gut microbiota.

scholarly journals Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism

2019 ◽  
Vol 64 (1) ◽  
pp. 1900789 ◽  
Author(s):  
Yang Zhang ◽  
Gerd Bobe ◽  
Johana S. Revel ◽  
Richard R. Rodrigues ◽  
Thomas J. Sharpton ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Bile Acid ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism

scholarly journals Functional microbiomics: Evaluation of gut microbiota-bile acid metabolism interactions in health and disease

Methods ◽  
2018 ◽  
Vol 149 ◽  
pp. 49-58 ◽  
Author(s):  
Benjamin H. Mullish ◽  
Alexandros Pechlivanis ◽  
Grace F. Barker ◽  
Mark R. Thursz ◽  
Julian R. Marchesi ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Health And Disease
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