Effectiveness and safety of herbal medicine for cancer‐related fatigue in lung cancer survivors: A systematic review and meta‐analysis

2020 ◽  
Author(s):  
Chan‐Young Kwon ◽  
Boram Lee ◽  
Moonkyo Kong ◽  
Seung Hyeun Lee ◽  
Hee‐Jae Jung ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Systematic Review ◽  
Herbal Medicine ◽  
Cancer Survivors ◽  
Meta Analysis ◽  
Cancer Related Fatigue

scholarly journals The effect of exercise on cancer-related fatigue in cancer survivors: a systematic review and meta-analysis

2018 ◽  
Vol Volume 14 ◽  
pp. 479-494 ◽  
Author(s):  
Ellen Kessels ◽  
Olga Husson ◽  
Christina M Van der Feltz-Cornelis
Keyword(s):  
Systematic Review ◽  
Cancer Survivors ◽  
Meta Analysis ◽  
Cancer Related Fatigue

scholarly journals Pharmacological Interventions for the Management of Cancer-Related Fatigue Among Cancer Survivors: Systematic Review and Meta-Analysis

2021 ◽  
Vol 20 ◽  
pp. 153473542110380
Author(s):  
Xuemei Sun ◽  
Yancong Chen ◽  
William KW Cheung ◽  
Irene XY Wu ◽  
Fang Xiao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Natural Products ◽  
Cancer Survivors ◽  
Meta Analysis ◽  
Random Effect ◽  
Minimal Important Difference ◽  
Risk Of Bias ◽  
Mean Difference ◽  
Pharmacological Interventions ◽  
Cancer Related Fatigue

Objective: Current guidelines have different recommendations on applying pharmacological interventions for managing cancer-related fatigue (CRF) among cancer survivors. This systematic review aims to synthesize clinical evidence on pharmacological interventions for managing CRF. Methods: Five databases were searched for potential randomized controlled trials (RCTs) from their inception until October 2020. RCTs assessing the effect of pharmacological treatments for CRF among cancer survivors were considered eligible. Clinical significance was determined by comparing the estimated effect with that of minimal important difference (MID). The risk of bias of each included RCT was appraised using the Cochrane risk of bias tool for randomized trials 2. Data were synthesized using random-effect pairwise meta-analyses. Results: A total of 15 RCTs (1238 participants) were included. The majority presented some concerns of bias arising from the randomization process and selection of the reported results. Meta-analysis showed that psychostimulant and wakefulness agents had statistically significant while clinically insignificant effects on the treatment of CRF (pooled weighted mean difference [WMD]: 2.8, 95% confidence interval [CI]: 0.2-5.4, I2: 0%, 3 RCTs, MID: 3.0-6.0). Three natural products, including Renshen Yangrong Tang (mean difference [MD]: −16.1, 95% CI: −8.9 to −23.3, MID: −17.3 to −11.4), Tualang honey (MD: 11.2, 95% CI: 7.1-15.3, MID: 3.0-6.0), and Shenmai injection plus Peptisorb (MD: −1.6, 95% CI: −2.1 to −1.1, MID: −1.1 to −0.8) demonstrated statistically and clinically significant effect in reducing CRF. Conclusions: Existing evidence showed promising effects of 3 natural products in reducing CRF among cancer survivors. The results from this study need to be further confirmed with well-designed and adequately powered RCTs that use validated instruments for the measurement of CRF.

Pharmacological interventions for the management of cancer-related fatigue among cancer survivors: systematic review and meta-analysis (Preprint)

2021 ◽  
Author(s):  
Xuemei Sun ◽  
Yancong Chen ◽  
William Cheung ◽  
Irene Wu ◽  
Fang Xiao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Natural Products ◽  
Cancer Survivors ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Minimal Important Difference ◽  
Risk Of Bias ◽  
Mean Difference ◽  
Pharmacological Interventions ◽  
Cancer Related Fatigue

BACKGROUND Background: Current guidelines have different recommendations on applying pharmacological interventions for managing cancer-related fatigue (CRF) among cancer survivors. OBJECTIVE Objective: This systematic review aims to synthesize clinical evidence on pharmacological interventions for managing CRF. METHODS Methods: Five databases were searched for potential Randomized controlled trials (RCTs) from their inception till October 2020. RCTs assessing the effect of pharmacological treatments for CRF among cancer survivors were considered eligible. Clinical significance was determined by comparing the estimated effect with that of minimal important difference (MID). The risk of bias of included RCTs were appraised using the Cochrane risk of bias tool for randomized trials 2. RESULTS Results: A total of 15 RCTs (1238 participants) were included. Majority presented some concerns of bias arising from the randomization process and selection of the reported result. Meta-analysis showed that psychostimulant and wakefulness agents had statistically significant while clinical insignificant effect on the treatment of CRF (pooled weighted mean difference (WMD): 2.8, 95% confidence interval (CI): 0.2 to 5.4, I2: 0%, 3 RCTs, MID: 3.0 to 6.0). Three natural products, including Renshen Yangrong Tang (mean difference (MD): -16.1, 95% CI: -8.9 to -23.3, MID: -17.3 to -11.4), Tualang honey (MD: 11.2, 95% CI: 7.1 to 15.3, MID: 3.0 to 6.0) and Shenmai injection plus Peptisorb (MD: -1.6, 95% CI: -2.1 to -1.1, MID: -1.1 to -0.8) demonstrated statistically and clinically significant effect in reducing CRF. CONCLUSIONS Conclusions: Existing evidence showed promising effects of three natural products in reducing CRF among cancer survivors. The results from this study need to be further confirmed with well-designed and adequate powered RCTs that use validated instruments for the measurement of CRF. CLINICALTRIAL The protocol of this systematic review has been registered in PROSPERO (registration number: CRD42018102347).

scholarly journals Herbal medicine on cancer-related fatigue of lung cancer survivors

Medicine ◽  
2020 ◽  
Vol 99 (5) ◽  
pp. e18968 ◽  
Author(s):  
Chan-Young Kwon ◽  
Boram Lee ◽  
Kwan-Il Kim ◽  
Beom-Joon Lee
Keyword(s):  
Lung Cancer ◽  
Herbal Medicine ◽  
Cancer Survivors ◽  
Cancer Related Fatigue
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